Dermatovenereology
doi: 10.25005/2074-0581-2026-28-1-206-214
SYSTEMIC ISOTRETINOIN IN THE TREATMENT OF ACNE IN THE SETTING OF OPISTHORCHIS INFECTION
Department of Dermatovenerology and Cosmetology, Siberian State Medical University, Tomsk, Russian Federation
Objective: To study the effect of systemic isotretinoin on the quality of life and the psychoemotional status of patients with acne and chronic opisthorchiasis who had and had not undergone eradication therapy.
Methods: This study was carried out at the Department of Dermatovenereology and Cosmetology of the Siberian State Medical University. A total of 43 patients diagnosed with moderate-to-severe and severe acne were observed. The concomitant disease was opisthorchiasis, confirmed by microscopic examination of duodenal contents. Twenty-three patients underwent eradication therapy and formed Group 1, while 20 patients did not undergo eradication therapy and were included in Group 2. In Group 1, 30% (n=7) were men and 70% (n=16) were women. In Group 2, 25% (n=5) were men and 75% (n=15) were women. The median age of patients in Group 1 was 22.0 [19.0; 25.0] years, and in Group 2 was 23.0 [19.0; 26.0] years. Patients received systemic isotretinoin for acne at a daily dose of 0.5-1 mg/kg until a cumulative dose of at least 120 mg/kg body weight and remission of the cutaneous process were achieved. Before systemic isotretinoin therapy and at 3, 6, and 18 months after treatment, the Dermatology Life Quality Index (DLQI), the Hospital Anxiety and Depression Scale (HADS), and the Dermatological Acne Index (DAI) were assessed.
Results: At 18 months after acne therapy, patients who had undergone eradication therapy showed the following scores: DLQI 1 [0; 1], HADS 0 [0; 1], and DAI 1 [0; 1] points. This indicates good tolerability of systemic isotretinoin, as well as improvement in patients’ quality of life and psychoemotional status.
Conclusion: Systemic isotretinoin for the treatment of acne in patients who underwent eradication therapy was well tolerated. Eighteen months after treatment, a positive effect on psychoemotional status and overall quality of life was observed.
Keywords: Dermatosis, acne, severe acne, systemic isotretinoin, remission, chronic opisthorchiasis.
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Authors' information:
Shirshkova Veronika Ivanovna,
Assistant Professor at the Department of Dermatovenerology and Cosmetology, Siberian State Medical University
ORCID ID: 0000-0001-6449-8918
E-mail: shirshkova@ssmu.ru
Khardikova Svetlana Anatolyevna,
Doctor of Medical Sciences, Full Professor, Head of the Department of Dermatovenerology and Cosmetology, Siberian State Medical University
ORCID ID: 0000-0001-9496-1221
E-mail: khardikova.s.a@mail.ru
Information about support in the form of grants, equipment, medications
The authors did not receive financial support from manufacturers of medicines and medical equipment
Conflicts of interest: No conflict
Address for correspondence:
Shirshkova Veronika Ivanovna
Assistant Professor at the Department of Dermatovenerology and Cosmetolo- gy, Siberian State Medical University
634050, Russian Federation, Tomsk, 2 Moskovsky trakt
Tel.: +7 (913) 8678465
E-mail: shirshkova@ssmu.ru
This work is licensed under a Creative Commons Attribution 4.0 International License.
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