ORIGINAL RESEARCH
Dermatovenereology
doi: 10.25005/2074-0581-2025-27-1-46-56
CLINICAL FEATURES OF CHRONIC BACTERIAL SEXUALLY TRANSMITTED INFECTIONS IN HIGH-RISK MEN

O.I. KASYMOV¹, B.I. SAIDZODA²,³, B.CH. SANGOV⁴, U.R. TADZHIBAEV⁵

1Department of Dermatovenereology with the Course of Cosmetology, Institute of Postgraduate Education in Healthcare of the Republic of Tajikistan, Dushanbe, Republic of Tajikistan
2Research Institute of Fundamental Medicine, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan
3Department of Dermatovenereology named after Professor Zoirov P.T., Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan
4Diagnostic and Treatment Center «Madadi Akbar», Dushanbe, Republic of Tajikistan
5Sughd Regional Clinical Center of Dermatovenereology, Khujand, Republic of Tajikistan

Objective: To determine the clinical features of chronic urogenital chlamydiosis (CUC) chronic urogenital ureaplasmosis-mycoplasmosis (CUUM) in high-risk men.

Methods: A total of 200 men aged 18 to 57 years with chronic bacterial sexually transmitted infections (CBSTIs) were examined. Of these, 103 (51.5%) constituted the high-risk group (Group 1), while 97 (48.5%) were in the comparison group (Group 2). CUC was diagnosed in 94 (47%) patients, and CUUM – in 106 (53%). Chronic urethritis (CU) was detected in 67 (33.5%) patients: chronic chlamydial urethritis (CCU) in 32 (16%) and chronic ureaplasma-mycoplasma urethritis (CUMU) in 35 (17.5%). Chronic prostatitis (CP) was found in 133 (66.5%) men: chronic chlamydial prostatitis (CCP) in 62 (31%) and chronic ureaplasma-mycoplasma prostatitis (CUMP) in 71 (35.5%). Microscopic, bacteriological, polymerase chain reaction (PCR), enzyme-linked immunosorbent assay (ELISA), and direct immunofluorescence (DIF) methods were used in the study.

Results: Mixed infections were identified in 128 (64%) patients: in 36 (54.0%) out of 67 CU cases and in 92 (69.2%) out of 133 CP cases, which is 1.3 times higher in the latter. Mixed infections were more common in the high-risk group, affecting 75 (72.8%) patients, whereas in the comparison group, this rate was 1.4 times lower (53 patients or 55.0%, p=0.008). CP was diagnosed in 73.8% (n=76) of the Group 1 patients, while in Group 2, it was 1.3 times less frequent (n=57 or 58.8%, p=0.025). Copulative (erectile dysfunction, painful ejaculation) and reproductive dysfunctions (infertility) were more commonly observed in the high-risk group than in the comparison group (p=0.002).

Conclusion: In patients with CUUM, upper urinary tract involvement (CP) was more common than lower urinary tract lesions (CU). Mixed infections were 1.4 times more frequent among patients with CUMP than among those with CUMU. Complications of CBSTIs (CP, infertility, copulative disorders) were more prevalent in high-risk patients compared to the comparison group.

Keywords: STIs, chronic chlamydial infection, chronic ureaplasma-mycoplasma infection, clinical features, high-risk group.

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Authors' information:

Kasymov Olim Ismailovich,
Doctor of Medical Sciences, Full Professor, Professor of the Department of Dermatovenereology with the Course of Cosmetology, Institute of Postgraduate Education in Healthcare of the Republic of Tajikistan
ORCID ID: 0000-0002-5568-8717
E-mail: o.kasymov@hotmail.com

Saidzoda Bakhromuddin Ikrom,
Doctor of Medical Sciences, Director, Research Institute of Fundamental Medicine, Avicenna Tajik State Medical University; Professor of the Department of Dermatovenereology named after Professor Zoirov P.T., Avicenna Tajik State Medical University
ORCID ID: 0000-0003-2497-6035
SPIN: 6668-0483
E-mail: saidzoda.bahromuddin@gmail.com

Sangov Bobokhon Chilaevich,
Candidate of Medical Sciences, Urologist, Diagnostic and Treatment Center «Madadi Akbar»
ORCID ID: 0009-0008-9283-8607
E-mail: bobokhon_72

Tadzhibaev Umidzhon Abdugafurovich,
Candidate of Medical Sciences, Head of the Department of Dermatology, Sughd Regional Clinical Center of Dermatovenereology
ORCID ID: 0009-0000-1816-4845
E-mail: umidzhon.tadzhibayev

Information about support in the form of grants, equipment, medications

The research was carried out in accordance with the research plan of Avicenna Tajik State Medical University (state registration number – 0118TJ400858). The authors did not receive financial support from manufacturers of medicines and medical equipment

Conflicts of interest: No conflict

Address for correspondence:

Saidzoda Bakhromuddin Ikrom
Doctor of Medical Sciences, Director, Research Institute of Fundamental Medicine, Avicenna Tajik State Medical University; Professor of the Department of Dermatovenereology named after Professor Zoirov P.T., Avicenna Tajik State Medical University

734026, Republic of Tajikistan, Dushanbe, Sino str., 29-31

Tel.: +992 (985) 154545

E-mail: saidzoda.bahromuddin@gmail.com


This work is licensed under a Creative Commons Attribution 4.0 International License.

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