Dermatovenereology
doi: 10.25005/2074-0581-2019-21-3-387-394
ANDROGEN-DEPENDENT DERMOPATHY IN WOMEN WITH KELOID SCARS

M.S. Valieva, K.M. Mukhamadieva, S.S. Ismatulloeva, E.V. Agafonova

Department of Dermatovenereology, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan

Objective: To explore the character of androgen-dependent dermopathy (ADD) in women with keloid scars.

Methods: 100 girls and women aged 15-28 years were examined, of whom 47 were with «true» and 53 were with «false» keloids. The evaluation of keloid scars was carried out using the Vancouver Scale (Baryza MJ, Baryza GA, 1995), modified Fistal HH (2006). Hyperandrogenic skin conditions were evaluated using the dermatological acne index (DAI), the Ferriman-Galway scale and the trichoscopy method.

Results: Acne was detected in 47 (100%) patients with «true» keloids and 40 (75.5%) patients with «false» keloids. Seborrheic dermatitis occurred in 32 (68.1%) cases of «true» and 27 (51.0%) observations of «false» keloids. In both groups of patients, the borderline condition between normal and excess haired, which in 22 (46.8%) patients with «true» keloids amounted to 10,5±1,2. Signs of androgenic alopecia were detected in 35 (74.5%) patients with «true» and 38 (71.7%) patients with «false» keloids. In «true» keloids, the density of hair in the androgen-dependent (parietal) area was lower than in patients with «false» keloid scars (171.3±14.6 vs. 273.2±17.5). The androgen-independent occipital area, the density of hair in patients with «true» scars was lower (191.3±11.2), than in patients with «false» keloids (241.0±18.5). In all patients with «true» keloids observed a combination of scarring with ADD. In 13 (24.5%) patients with «false» keloids correlation with ADD was not observed.

Conclusion: The most typical ADD in women with keloid scars are the acne and androgenic alopecia, which occur respectively, in 100% and 74.5% of cases in «true», and in 75.5% and 71.6% with «false» keloids. Consequently, hyperandrogenic skin conditions in women may be risk factors for keloids and indicate a hormonal imbalance in this contingent of patients.

Keywords: Androgen-dependent dermopathy, keloids , acne, androgenic alopecia.

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References
  1. Jennifer MH, Kevin LMc, Kelly AC, Dorothy MS. Partial epithelialmesenchymal transition in keloid scars: regulation of keloid keratinocyte gene expression by transforming growth factorβ1. Burns Trauma. 2016;4(1):30. Available from: https://doi.org/10.1186/s41038-016-0055-7.
  2. Taganov AV, Bizunova MA, Krinitsyna YuM, Sergeeva IG. Analiz metodov lecheniya keloidnykh rubtsov [Analysis of methods for treating keloid scars]. Klinicheskaya dermatologiya i venerologiya. 2017;3:97-102.
  3. Juckett G, Adams HH. Management of keloids and hypertrophic scars. Am Fam Phys. 2009;80(3):253-60.
  4. Vladimirova O.V. Opyt pervichnoy i vtorichnoy profilaktiki izbytochnogo rubtseobrazovaniya [Experience of primary and secondary prevention of excessive scarring] Meditsinskiy vestnik Severnogo Kavkaza. 2009;1:30-1.
  5. Hochman B, Isoldi FC, Furtado F, Ferreira LM New approach to the understanding of keloid: psychoneuroimmune-endocrine aspects. Clin Cosmetic Investig Dermatol. 2015;8:67-73. Available from: https://doi. org/10. 2147/CCID.S49195.
  6. Ilina IYu, Dobrokhotova YuE, Yumina SV. Giperandrogeniya razlichnogo geneza i eyo vozmozhnoe vliyanie na kollagenoobrazovanie [Hyperandrogenism of various origins and its possible effect on collagen formation]. Vestnik RUDN, seriya Meditsina. 2009;5:224-31.
  7. Schneider M, Meites E, Daane SP: Keloids: which treatment is best for your patient? J Fam Pract. 2013;62(5):227-33.
  8. Kobets MV, Vasilyeva LS, Mikhalevich IM, Malyshev VV. Reaktivnost’ organizma pri gipertroficheskikh rubcah kozhi [Body reactivity in case of hypertrophic skin scars]. Byulleten’ VSNTS SO RAMN. 2014;3:35-40.
  9. Alekseeva NT. Uchastie kletochnogo komponenta v regeneratsii rany [The participation of the cellular component in wound regeneration]. Zhurnal anatomii i gistopatologii. 2014;3(1):9-15.
  10. Liga AB, Ukhina TV, Shimanovskiy NL. Aktivnost’ lizosomal’nykh fermentov fibroblastov kozhi krys pri vozdeystvii progesterona i novogo gestagena ABMP [The activity of lysosomal enzymes of rat skin fibroblasts when exposed to progesterone and the new progestogen ABMP]. Byulleten’ еksperimental’noy biologii i meditsiny. 2008;145(1):50-2.
  11. Zhidkova YuYu, Penyevskaya NA, Stepanova EF. Predposylki k sovershenstvovaniyu farmakoprofilaktiki gipertroficheskikh i keloidnykh rubtsov [Prerequisites for improving the pharmacoprophylaxis of hypertrophic and keloid scars]. Nauchnye vedomosti BelGU. Ser. Meditsina. Farmatsiya. 2012;18(3):12-5.
  12. Wolfram D, Tzankov A, Pülzl P, Piza-Katzer H. Hypertrophic scars and keloids – a review of their pathophysiology, risk factors, and therapeutic management. Dermatol Surg. 2009;35(2):171-81. Available from: https:// doi.org/10.1111/j.1524-4725.2008.34406.x.
  13. Yutskovskaya YuA, Malova TA, Eryomenko IE. Androgenzavisimye sindromy kozhi u zhenshchin: rol’ antiandrogennoy terapii na sovremennom etape [Androgen-dependent skin syndromes in women: the role of antiandrogen therapy at the present stage]. Klinicheskaya dermatologiya i venerologiya. 2010;5:84-9.
  14. Shabardina OV, Kokhan MM. Farmakoekonomicheskiy analiz razlichnykh metodov terapii tyazhyolykh form akne [Pharmacoeconomic analysis of various therapies for severe acne]. Sovremennye problemy dermatovenerologii, immunologii i vrachebnoy kosmetologii. 2010;1:60-6.
  15. Mareeva AN. Osobennosti klinicheskikh proyavleniy androgennoy alopetsii u zhenshchin reproduktivnogo vozrasta [Features of the clinical manifestations of androgenetic alopecia in women of reproductive age]. Vestnik dermatologii i venerologii. 2011;2:103-7.
  16. Sato T, Kurihara H, Akimoto N, Noguchi N, Sasatsu M. Augmentation of gene expression and production of Promatrix metal-loproteinase 2 by propionibacterium acnes-derived factors in hamster sebocytes and dermal fibroblasts: a possible mechanism for acne scarring. Biol Pharm Bull. 2011;34(2):295-9.
  17. Kruglova LS, Kolcheva PA, Korchazhkina NB. Obzor sovremennykh metodov korrektsii rubtsov postakne [A review of modern post-acne scar correction methods. Bulletin of new medical technologies]. Vestnik novykh meditsinskikh tekhnologiy. 2018;25(4):155-63.
  18. Goodman GJ. Treatment of acne scarring. Int J Dermatol. 2011;50(10):1179- 94.
  19. Kondrat’eva YuS, Shepileva TN, Kokina OA, Subbotin EA. Sravnitel’nyy analiz effektivnosti kombinirovannoy topicheskoy terapii bol’nykh papulo-pustulyoznoy formoy akne lyogkoy i sredney stepeni tyazhesti [A comparative analysis of the effectiveness of combined topical therapy in patients with mild to moderate papulopustular acne]. Vestnik dermatovenerologii i kosmetologii. 2015;3:135-40.
  20. Mansurova GN, Tukhvatullina LM. Giperandrogeniya u devochekpodrostkov [Hyperandrogenism in adolescent girls]. Prakticheskaya meditsina. 2008;7:66-8.
  21. Zhukova OV, Potekaev NN, Stenko AG, Burdina AA. Patogenez i gistomorfologicheskie osobennosti rubtsovykh izmeneniy kozhi [Pathogenesis and histomorphological features of cicatricial changes in the skin]. Klinicheskaya dermatologiya i venerologiya. 2009;3:4-9.
  22. Sidorenko YuS, Maksimov GK, Przhdetskiy YuV. Rol’ neyro-gumoral’nykh faktorov v patogeneze keloidnykh rubtsov [The role of neuro-humoral factors in the pathogenesis of keloid scars]. Vestnik nauchnogo tsentra RAN. 2005;1(2):85-90.

Authors' information:

Valieva Mukhabbat Saydalievna
Assistant of the Department of Dermatovenereology, Avicenna Tajik State Medical University
ORCID ID: 0000-0001-8702-0968
Author ID: 38171142
SPIN: 3468-4440
E-mail: muhabbat_v71@mail.ru

Mukhamadieva Kibriyokhon Mansurovna
Doctor of Medical Sciences, Head of the Department of Dermatovenereology, Avicenna Tajik State Medical University
ORCID ID: 0000-0002-4264-2816
Author ID: 998398
SPIN: 1880-3870
E-mail: kibriyo_67@mail.ru

Ismatulloeva Savrina Sadulloevna
Candidate of Medical Sciences, Assistant of the Department of Dermatovenenereology, Avicenna Tajik State Medical University
ORCID ID: 0000-0002-0252-7098
Author ID: 857443
SPIN: 1840-5188
E-mail: damsav@mail.ru

Agafonova Elena Vladimirovna
Clinical Resident of the Department of Dermatovenereology, Avicenna Tajik State Medical University
ORCID ID: 0000-0001-9988-6312
Author ID: 857443
E-mail: elena.agafonova1985@gmail.com

Information about support in the form of grants, equipment, medications

The work was carried out according to the plan of scientific research works of the Avicenna Tajik State Medical University (state registration number – 0118Т400858). The authors did not receive financial support from manufacturers of medicines and medical equipment.

Conflicts of interest: No conflict

Address for correspondence:

Mukhamadieva Kibriyokhon Mansurovna
Doctor of Medical Sciences, Head of the Department of Dermatovenereology, Avicenna Tajik State Medical University

734003, Republic of Tajikistan, Dushanbe, Rudaki Ave., 139

Tel.: +992 (931) 277575

E-mail: kibriyo_67@mail.ru

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