Dermatovenereology

doi: 10.25005/2074-0581-2019-21-3-387-394
ANDROGEN-DEPENDENT DERMOPATHY IN WOMEN WITH KELOID SCARS

M.S. Valieva, K.M. Mukhamadieva, S.S. Ismatulloeva, E.V. Agafonova

Department of Dermatovenereology, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan

Objective: To explore the character of androgen-dependent dermopathy (ADD) in women with keloid scars.

Methods: 100 girls and women aged 15-28 years were examined, of whom 47 were with «true» and 53 were with «false» keloids. The evaluation of keloid scars was carried out using the Vancouver Scale (Baryza MJ, Baryza GA, 1995), modified Fistal HH (2006). Hyperandrogenic skin conditions were evaluated using the dermatological acne index (DAI), the Ferriman-Galway scale and the trichoscopy method.

Results: Acne was detected in 47 (100%) patients with «true» keloids and 40 (75.5%) patients with «false» keloids. Seborrheic dermatitis occurred in 32 (68.1%) cases of «true» and 27 (51.0%) observations of «false» keloids. In both groups of patients, the borderline condition between normal and excess haired, which in 22 (46.8%) patients with «true» keloids amounted to 10,5±1,2. Signs of androgenic alopecia were detected in 35 (74.5%) patients with «true» and 38 (71.7%) patients with «false» keloids. In «true» keloids, the density of hair in the androgen-dependent (parietal) area was lower than in patients with «false» keloid scars (171.3±14.6 vs. 273.2±17.5). The androgen-independent occipital area, the density of hair in patients with «true» scars was lower (191.3±11.2), than in patients with «false» keloids (241.0±18.5). In all patients with «true» keloids observed a combination of scarring with ADD. In 13 (24.5%) patients with «false» keloids correlation with ADD was not observed.

Conclusions: The most typical ADD in women with keloid scars are the acne and androgenic alopecia, which occur respectively, in 100% and 74.5% of cases in «true», and in 75.5% and 71.6% with «false» keloids. Consequently, hyperandrogenic skin conditions in women may be risk factors for keloids and indicate a hormonal imbalance in this contingent of patients.

Keywords: Androgen-dependent dermopathy, keloids , acne, androgenic alopecia.

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Authors informations:

Valieva Mukhabbat Saydalievna Assistant of the Department of Dermatovenereology, Avicenna Tajik State Medical University ORCID ID: 0000-0001-8702-0968 Author ID: 38171142 SPIN: 3468-4440 E-mail: muhabbat_v71@mail.ru

Mukhamadieva Kibriyokhon Mansurovna Doctor of Medical Sciences, Head of the Department of Dermatovenereology, Avicenna Tajik State Medical University ORCID ID: 0000-0002-4264-2816 Author ID: 998398 SPIN: 1880-3870 E-mail: kibriyo_67@mail.ru

Ismatulloeva Savrina Sadulloevna Candidate of Medical Sciences, Assistant of the Department of Dermatovenenereology, Avicenna Tajik State Medical University ORCID ID: 0000-0002-0252-7098 Author ID: 857443 SPIN: 1840-5188 E-mail: damsav@mail.ru

Agafonova Elena Vladimirovna Clinical Resident of the Department of Dermatovenereology, Avicenna Tajik State Medical University ORCID ID: 0000-0001-9988-6312 Author ID: 857443 E-mail: elena.agafonova1985@gmail.com

Address for correspondence:

Mukhamadieva Kibriyokhon Mansurovna
Doctor of Medical Sciences, Head of the Department of Dermatovenereology, Avicenna Tajik State Medical University

734003, Republic of Tajikistan, Dushanbe, Rudaki Ave., 139

Tel.: +992 (931) 277575

E-mail: kibriyo_67@mail.ru

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