Dermatovenereology

doi: 10.25005/2074-0581-2020-22-1-40-44
CLINICAL AND IMMUNOLOGICAL CHANGES OF NON-GONOCOCCAL URETHRITIS

M.A. Gadoev, B.I. Saidzoda

Department of Dermatovenereology, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan

Objective: To study the clinical features and the state of general immunological reactivity in non-gonococcal urethritis (NGU) in men.

Methods: Examined 100 men between the ages of 20 and 48 years: 75 patients of NGU (main group) and 25 healthy (control group). The average age of the patients was 26.7±1.7 years, and the male of control group was 27.9±1.7 years. Clinical, microscopic, immunological research methods were used, including direct immunofluorescence (DIF), polymerase chain reaction (PCR).

Results: Ureaplasma urealyticum was found in 37 (49.3%) patients, 33 (44%) had Chlamydia trachomatis, 23 (30.7%) had Mycoplasma genitalium, 16 (21.3%) had Trichomonas vaginalis. In 24 (32%) of NGU patients had a mixed infection: in 14 (18.7%) had a combination of two STIs and in 10 (13, 3%) had three infections. In 51 (68%) of patients the process passed in the form of monoinfection. Various complaints (dysuric disorders, pain, discomfort and agglutination of the labium urethra) were presented by 51 (68%) of sick patients. The excretions from the urethra were marked in 46 (61.3%) of patients, reproductive disorders are 3 times less common. Immunological disorders were manifested by a decrease in CD4 and CD8 lymphocytes, PHA, PN and IL-10, increase – IgM, IgG, CIC, TNFα, IL-1β.

Conclusions: The most common cause of NGU is Ureaplasma urealyticum and Chlamydia trachomatis. In most cases NGU proceeds in the form of monoinfection. Subjective and objective symptoms occur in 64% and 59% of patients, respectively. Immunological disorders were detected in 71% of patients.

Keywords: Non-gonogococcal urethritis, direct immunofluorescence, immunoenzyme method , polymerase chain reaction.

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Authors informations:

Gadoev Maruf Ahmadovich
Applicant, Department of Dermatovenereology, Avicenna Tajik State Medical University
E-mail: rkvd_1@mail.ru

Saidzoda Bakhromuddin Ikrom
Candidate of Medical Sciences, Associate Professor of the Department of Dermatovenereology, Avicenna Tajik State Medical University
ORCID ID: 0000-0003-2497-6035
SPIN: 6668-0483
Tel.: +992 (985) 154545
E-mail: saidov_bahromuddin@mail.ru

Information about the source of support in the form of grants, equipment, and drugs

The work was carried out according to the plan of scientific research works of Avicenna Tajik State Medical University (state registration number – 0118T400858). The authors did not receive financial support from manufacturers of medicines and medical equipment

Conflict of interest: No conflict

Address for correspondence:

Saidzoda Bakhromuddin Ikrom
Candidate of Medical Sciences, Associate Professor of the Department of Dermatovenereology, Avicenna Tajik State Medical University

734003, Republic of Tajikistan, Dushanbe, Rudaki Ave., 139

Tel: +992 (985) 154545

E-mail: saidov_bahromuddin@mail.ru

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