REVIEW ARTICLE
Dermatovenereology
doi: 10.25005/2074-0581-2025-27-2-428-440
CLINICAL AND EPIDEMIOLOGICAL ASPECTS OF SYPHILITIC VISCEROPATHY AND THE RELEVANCE OF EARLY DETECTION OF LIVER LESIONS

A.A. SYDIKOV1, G.B. PYAGAY2, A.K. MANGITOV1

1Fergana Medical Institute of Public Health, Fergana, Republic of Uzbekistan
2Tashkent State Dental Institute, Tashkent, Republic of Uzbekistan

Visceral syphilis can manifest as cardiovascular involvement that can be observed even in the early stages of syphilis. Additionally, the nervous system, kidneys, and eyes can also be affected. The likelihood of liver damage in the early stages of syphilis remains a topic of debate; however, it is wellestablished that in the laterstages,syphilis can involve the liver, causing interstitial inflammation and the formation of gummas. Recent epidemiological trends show a rise in the proportion of latent syphilis within the overall morbidity. This trend underscores the need for greater awareness regarding manifestations of visceralsyphilis. Chronic inflammation of the liver can potentially lead to chronic granulomatousinflammation, fibrosis, and cirrhosis. To explore these issues, a literature review was conducted using the PubMed, Science Direct, and eLibrary databases, utilizing key terms such as modern epidemiology of syphilis”, “visceral syphilis”, “syphilitic disease of the liver”, and “syphilitic hepatitis”. The search strategy encompassed all clinical trials, observational studies, case reports, and literature reviews published within the past decade, while excluding reports from non-peerreviewed sources. The literature review yielded a significant number of reports discussing liver lesions in the early stages of syphilis. Evidence includes clinical presentations of cholestasis and abnormal liver biochemical markers in patients with syphilis, which tended to normalize following targeted treatment. Furthermore, the diagnosis of syphilitic liver lesions is supported by the identification of treponemal antigens in liver biopsies, confirmed through immunohistochemical examination of the specimens.

Keywords: Syphilis, epidemiological features, visceral syphilis, syphilitic disease of the liver, pathomorphological changes in the liver in syphilis, diagnosis of syphilitic disease of the liver.

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Authors' information:

Sydikov Akmal Abdikakharovich,
Doctor of Medical Sciences, Full Professor, Rector of Fergana Medical Institute of Public Health
ORCID ID: 0000-0002-0909-7588
SPIN: 3812-8400
Author ID: 799109
E-mail: medik85@bk.ru.

Pyagay Grigoriy Borisovich,
Doctor of Medical Sciences, Associate Professor of the Department of Dermato-Oncopathology, Tashkent State Dental Institute
ORCID ID: 0000-0002-6456-6594
SPIN: 2941-7297
Author ID: 1106302
E-mail: gregbae@mail.ru

Mangitov Alimbay Kamalovich,
Applicant of the Fergana Medical Institute of Public Health
ORCID ID: 0009-0004-6507-9896
SPIN: 3893-3353
Author ID: 1254373
E-mail: olim.mangitov@mail.ru

Information about support in the form of grants, equipment, medications

The authors did not receive financial support from manufacturers of medicines and medical equipment

Conflicts of interest: No conflict

Address for correspondence:

Pyagay Grigoriy Borisovich
Doctor of Medical Sciences, Associate Professor of the Department of Dermato-Oncopathology, Tashkent State Dental Institute

100213, Republic of Uzbekistan, Tashkent, Bektemir district, Vodnik, 29-125

Tel.: +998 (901) 755133

E-mail: gregbae@mail.ru


This work is licensed under a Creative Commons Attribution 4.0 International License.

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