Pharmacology

doi: 10.25005/2074-0581-2021-23-2-216-234
STUDY OF ANTIBACTERIAL ACTIVITY OF EXTRACTS OF DIFFERENT SPECIES OF THE GENUS Allium GROWING IN TAJIKISTAN

S. Satorov, F.D. Mirzoeva

Department of Microbiology, Immunology and Virology, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan

Objective: Comparative assessment of the antimicrobial activity of widespread and endemic species of the genus Allium growing in Tajikistan.

Methods: Parent ethanol extracts were obtained from fresh plants of fifteen species of onions from different climatic regions of Tajikistan. Using disk diffusion method the antibacterial activity of species of the genus Allium was studied against the four types of standard museum microorganisms (test strains): Staphylococcus aureus (ATCC 4929), Pseudomonas aeruginosa (ATCC 4930), Klebsiella pneumoniae (ATCC 4927), and Escherichia coli (ATCC 4928).

Results: The highest antimicrobial activity against Staphylococcus aureus (S. aureus) test was found in the extracts of A. oschaninii O. Fedtsch., A. altaicum Pall., and A. sativum L. Extracts from A. obliquum L., A. longicuspis Regel, A. nutans L., and A. senescens L. demonstrated a weak antistaphylococcal effect. Pseudomonas aeruginosa (Ps. aeruginosa) was shown to be sensitive to the endemic species A. schugnanicum Vved., mainly to its bulb extract. Reference strain of Klebsiella pneumoniae (Kl. pneumoniae) exhibited sensitivity to the extracts of the widespread species A. sativum L. and the endemic species A. schugnanicum Vved. High bactericidal activity against Escherichia coli (E. coli) reference strain was shown by the extract of the A. oschaninii O. Fedtsch. species.

Conclusion: The study demonstrated that all species of the genus Allium possessed a bactericidal effect of varying degrees. The widespread A. oschaninii O. Fedtsch., and the endemic A. schugnanicum Vved. species showed the highest antibacterial activity.

Keywords: Plants, growth inhibition, extracts, reference strains of bacteria.

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Author information:


Satorov Saidbeg
Doctor of Medical Sciences, Full Professor, Head of the Department of Microbiology, Immunology and Virology, Avicenna Tajik State Medical University
Researcher ID: S-9073-2016
Scopus ID: 10419425154
ORCID ID: 0000-0003-1101-1840
SPIN: 2523-8682
Author ID: 78634
E-mail: sattorion@mail.ru

Mirzoeva Fazila Davlatalievna
Assistant, Department of Microbiology, Immunology and Virology, Avicenna Tajik State Medical University
ORCID ID: 0000-0003-0187-0334
E-mail: fazila.mirzoeva88@mail.ru

Information about support in the form of grants, equipment, medications

The authors did not receive financial support from companies manufacturing medications and medical equipment

Conflicts of interest: No conflict

Address for correspondence:


Satorov Saidbeg
Doctor of Medical Sciences, Full Professor, Head of the Department of Microbiology, Immunology and Virology, Avicenna Tajik State Medical University

734003, Republic of Tajikistan, Dushanbe, Rudaki Ave., 139

Tel.: +992 (987) 842424

E-mail: sattorion@mail.ru

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