Pharmacology
doi: 10.25005/2074-0581-2019-21-4-643-654
COMPARATIVE CHARACTERISTICS OF ANTIBACTERIAL ACTIVITY OF PLANTS GROWING IN THE CENTRAL PART OF THE REPUBLIC OF TAJIKISTAN

S. Satorov1, F. Mirzoeva1, Sh. Satorov2, M.Vakhidova2, V. Dushenkov3

1Department of Microbiology, Immunology and Virology, Аvicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan
2Department of Plant Biology, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ, USA
3Department of Natural Sciences, Hostos Community College, City University of New York, Bronx, NY, USA

Objective: To evaluate the spectrum of antibacterial activity of plants growing in the central part of the Republic of Tajikistan.

Methods: The antibacterial properties of 18 plant species from the 14 families were studied. The extract samples on dry filter discs were prepared according to the method developed at Rutgers University. Screens-to-Nature (STN) and disc diffusion (DD) methods were used to assess antimicrobial properties of the extracts. The antimicrobial activity of plant extracts was determined against four types of pathogenic standard museum strains of Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, as well as by using the same types of microorganisms isolated from inpatients (the hospital strains).

Results: Ethanol extract from leaves of Artemisia absinthium demonstrated a broad-spectrum high degree of antimicrobial activity against both reference and hospital strains of S. aureus, P. aeruginosa and E. coli. The Morus nigra extract also showed broad-spectrum activity, however overall antibacterial activity was lower than in A. absinthium. In general, tested extracts were less effective against E. coli. None of the 18 tested extracts showed activity against K. pneumoniae.

Conclusion: Artemisia absinthium and Morus nigra have a broad-spectrum antimicrobial effect and differ only in the degree of activity. The extracts of Amaranthus tricolor and Arctium tomentosum, Indigofera tinctoria, Punica granatum were characterized by a somewhat narrower spectrum of action. Mentha arvensis and Allium suworowii had approximately the same degree of inhibitory ability.

Keywords: Plants, growth inhibition, extracts, hospital strains of bacteria, reference strains of bacteria.

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Authors' information:

Satorov Saidbeg
Doctor of Medical Sciences, Professor, Head of the Department of Microbiology, Immunology and Virology, Avicenna Tajik State Medical University
SCOPUS: 10419425154
Researcher ID: S-9073-2016
ORCID ID: 0000-0003-1101-1840
Author ID: 78634
SPIN: 2523-8682
E-mail: sattorion@mail.ru

Mirzoeva Fazila
Assistant, Department of Microbiology, Immunology and Virology, Avicenna Tajik State Medical University
ORCID ID: 0000-0003-0187-0334
E-mail: fazila.mirzoeva88@mail.ru

Satorov Shukhrat
Intern of the Department of Plant Biology, School of Environmental and Biological Sciences, Rutgers University
SCOPUS: 1742026179
ORCID ID: 0000-0003- 3072-1135
E-mail: sufion@mail.ru

Vakhidova Manizha
Intern of the Department of Plant Biology, School of Environmental and Biological Sciences, Rutgers University
ORCID ID: 0000-0002-3366-1580
SPIN: 9366-9702
E-mail: sufion@mail.ru

Dushenkov Vyacheslav
PhD, Associate Professor at the Department of Natural Sciences, Hostos Community College, City University of New York
SCOPUS: 6507356097
Researcher ID: AAE-8520-2019
ORCID ID: 0000-0001- 5176-7461
Author ID: 638952
SPIN: 50533-0988
E-mail: dushenkov@sebs.rutgers.edu

Information about support in the form of grants, equipment, medications

The authors did not receive financial support from manufacturers of medicines and medical equipment

Conflicts of interest: No conflict

Address for correspondence:

Satorov Saidbeg
Doctor of Medical Sciences, Professor, Head of the Department of Microbiology, Immunology and Virology, Avicenna Tajik State Medical University

734003, Republic of Tajikistan, Dushanbe, Rudaki Ave., 139

Tel.: +992 (987) 842424

E-mail: sattorion@mail.ru

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