Pharmacology

doi: 10.25005/2074-0581-2018-20-4-421-426
MOLECULAR APPROACH TO DETERMINE THE HOT AND COLD TEMPERAMENTS IN PLANTS ACCORDING AVICENNA CONCEPTS, THE ROLE OF MAGNESIUM

M. Sharofova1,2, I. Aldybiat3, Sh. Sagdieva1, N. Burkhonova1, Yu. Nuraliev2,4, F. Rahimi1, M. Mirshahi1,3

1Research Center for Innovative Technologies, Academy of Sciences of the Republic of Tajikistan, Dushanbe, Republic of Tajikistan
2Institute of Avicenna’s Medicine and Pharmacology, Dushanbe, Republic of Tajikistan
3University of Sorbonne Paris Cité-Paris 7, Lariboisière Hospital, INSERM U965, 75010 Paris, France
4Central Scientific-Research Laboratory, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan

Objective: The molecular approach of millenary notion about hot and cold temperaments (mizaj) in plants according to Avicenna concepts is not investigated. The aim of this study is to analyze the correlation between mizaj property of plants from the Tajikistan area and their amount/quality of metal.

Methods: We analyzed the presence of several metals that implicated in body’s homeostasis integrity, such as sodium, potassium, calcium, and magnesium, in several edible plants (n=23) from different regions in Tajikistan. Samples (n=43) of plant’s parts including seeds, flower, leaf, stem and root were analyzed for their elements’ composition using Energy Dispersive X-Ray Analysis (EDX) which incorporates Scanning Electron Microscopy (SEM).

Results: We didn’t find any correlation between the area of the collected samples and the amount of metal absorbance by the plants. The metals distributions of plant’s parts varied from one to the other. In this study, we found strict correlation between the amount of magnesium and the temperament properties of the plants reported by Avicenna. The magnesium was detected in high amount in Achillea millefolium L., Rosa canina L., Coriandrum sativum L., Foeniculum vulgare Mill. and Nigella sativa L.

Conclusion: The presence of high concentration of magnesium in the edible plants can be considered as a metal contribution (factor) in hot mizaj property and may lead to energy regeneration and wellbeing after consumption.

Keywords: Metal, hot and cold nature, plants, Avicenna, magnesium, Tajikistan.

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References
  1. Avicenna «Works». Volume 13. Canon of medical science: The second book. Dushanbe: Donish; 2012. 958 p.
  2. Sharofova M, Nuraliev Yu, Sukhrobov P, Sagdieva Sh, Dushenkov V. Can Avicenna help manage the diabetes epidemic in Central Asia? Central Asian Journal of Medical Sciences. 2017;3(3):200-20.
  3. Lehninger AL. Bole of metal ions in enzyme systems. Physiol Bev. 1950;30:393- 429.
  4. Li TK, Vallee BL. Trace elements, Section B. The biochemical and nutritional role of trace elements. In: Goodhart RS, Shils ME (eds.). Modem nutrition in health and disease. Philadelphia, USA: Lea and Febiger; 1973. p. 372-399.
  5. Biordan JF, Vallee BL. The functional role of metals in metalloenzymes. Protein-metal interactions. Friedman M. (ed). Advances in Exp Med Biol. 1974;48:33-58.
  6. Li HC. Activation of brain calcineurin phosphatase towards nonprotein phosphoesters by Ca2+, calmodulin, and Mg2+. J Biol Chem. 1984;259(14):8801-7.
  7. Elnatan D, Agard DA. Calcium binding to a remote site can replace magnesium as cofactor for mitochondrial Hsp90 (TRAP1) ATPase activity. J Biol Chem. 2018;293(35):13717-24. Available from: http://dx.doi.org/10.1074/jbc. RA118.003562.
  8. Parsiegla G, Noguere C, Santell L, Lazarus RA, Bourne Y. The structure of human DNase I bound to magnesium and phosphate ions points to a catalytic mechanism common to members of the DNase I-like superfamily. Biochemistry. 2012;51(51):10250-8. Available from: http://dx.doi. org/10.1021/bi300873f.
  9. Inoue A, Takagi Y, Taira K. Importance of magnesium ions in the mechanism of catalysis by a hammerhead ribozyme: strictly linear relationship between the ribozyme activity and the concentration of magnesium ions. Magnes Res. 2003;16(3):210-7.
  10. Sharofova MU, Nuraliev YuN, Sagdieva ShS, Sukhrobov PSh. Mekhanizm diabetogeneza po Avitsenne i diabetogennye faktory riska [Diabetes genesis mechanism by Avicenna and risk factors]. Obzory po klinicheskoy farmakologii i lekarstvennoy terapii. 2018;16(2):74-9.
  11. Sharofova MU, Sagdieva ShS, Abdulloev SF, Maslov VA, Rahimi F, Mirshahi M. To the question of the content of transition elements in plant structures. Reports of the Academy of Sciences of the Republic of Tajikistan. 2018;61(4):350-9.
  12. Van Nostrand’s Scientific Encyclopedia, magnesium (in biological systems). 2006. Available from: http://dx.doi.org/10.1002/0471743984.vse4741.
  13. Leroy J. Necessite du magnesium pour la croissance de la souris. Comptes Rendus des Séances de la Société de Biologie. 1926;94:431-3.
  14. Lusk JE, Williams RJP, Kennedy EP. Magnesium and the growth of Escherichia coli. Journal of Biological Chemistry. 1968;243(10):2618-24.
  15. Labyntseva RD, Slinchenko NM, Veklich TO, Rodik RV, Cherenok SO, Boĭko VI, et al. Comparative study of calixarene effect on Mg2+-dependent ATPhydrolase enzymatic systems from smooth muscle cells of the uterus. Ukr Biokhim Zh. 2007;79(3):44-54.
  16. Elin RJ. Magnesium: the fifth but forgotten electrolyte. Am J Clin Pathol. 1994;102:616-22. Available from: http://dx.doi.org/10.1093/ajcp/102.5.616.
  17. Li FY, Chaigne-Delalande B, Kanellopoulou C. Second messenger role for Mg2+ revealed by human T-cell immunodeficiency. Nature. 2011;475:471-6. Available from: http://dx.doi.org/10.1038/nature10246.
  18. Fawcett WJ, Haxby EJ, Male DA. Magnesium: physiology and pharmacology. Br J Anaesth. 1999;83:302-20. Available from: http://dx.doi.org/10.1093/ bja/83.2.302
  19. Shechter M, Kaplinsky E, Rabinowitz B. The rationale of magnesium supplementation in acute myocardial infarction. A review of the literature. Arch Intern Med. 1992;152:2189-96. Available from: http://dx.doi. org/10.1001/archinte.1992.00400230015003.
  20. Montes de Oca A, Guerrero F, Martinez-Moreno JM. Magnesium inhibits Wnt/beta-catenin activity and reverses the osteogenic transformation of vascular smooth muscle cells. PLoS One. 2014;9:e89525. Available from: http://dx.doi.org/10.1371/journal.pone.0089525.
  21. Rude RK. Magnesium deficiency: a cause of heterogeneous disease in humans. J Bone Miner Res. 1998;13:749-58. Available from: http://dx.doi. org/10.1359/jbmr.1998.13.4.749.
  22. Alfrey AC, Miller NL. Bone magnesium pools in uremia. J Clin Invest. 1973;52:3019-27. Available from: http://dx.doi.org/10.1172/JCI107500.
  23. Fang X, Han H, Li M, Liang C, Fan Z, Aaseth J, et al. Dose-response relationship between dietary magnesium intake and risk of type 2 diabetes mellitus: A systematic review and meta-regression analysis of prospective cohort studies. Nutrients. 2016;8(11):739.
  24. Sharofova M, Nuraliev Yu, Ganiev Kh, Suhrobov P, Zubaydova T, Samandarov N, Mirshahi M. Acid dietary as diabetogenic risk factors. IESc Res J. 2016;2(9):51-6.

Author information:


Sharofova Mizhgona,
Candidate of Medical Sciences, Head of the Laboratory of Biotechnology, Research Center for Innovative Technologies, Academy of Sciences of the Republic of Tajikistan; Director of the Institute of Avicenna’s Medicine and Pharmacology

Aldybiat Iman, PhD,
Post Doctorant in University of Sorbonne Paris Cité-Paris 7, Lariboisière Hospital

Sagdieva Shoista,
Candidate of Medical Sciences, Senior Researcher of the Laboratory of Biological Sciences, Research Center for Innovative Technologies, Academy of Sciences of the Republic of Tajikistan

Burkhonova Nigora,
Junior Researcher of the Laboratory of Biotechnology, Research Center for Innovative Technologies, Academy of Sciences of the Republic of Tajikistan

Nuraliev Yusuf,
Doctor of Medical Sciences, Honorary Professor of the Central Scientific-Research Laboratory, Avicenna Tajik State Medical University; Co- Director of the Institute of Avicenna’s Medicine and Pharmacology

Rahimi Farhod,
Doctor of Physical and Mathematical Sciences, Professor, Academician and President of the Academy of Sciences of the Republic of Tajikistan

Mirshahi Massoud,
Professor, MD, PhD, University of Sorbonne Paris Cité- Paris 7, Lariboisière Hospital, Member of the Academy of Sciences of the Republic of Tajikistan

Conflicts of interest: No conflict

Address for correspondence:


Massoud Mirshahi MD, PhD
Université de Sorbonne Paris Cité UMR Paris 7, INSERM U965 Carcinose, Angiogenèse et Recherche Translationnelle L’Hôpital Lariboisière 41 Bd de la Chapelle

75010, Paris, France

Tel.: 00 33 1 53216775

Fax: 00 33 1 53216739

E-mail: massoud.mirshahi@inserm.fr

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