Pharmacology
doi: 10.25005/2074-0581-2020-22-1-98-105
ANTIBACTERIAL, ANTIFUNGAL, ANTIOXIDANT ACTIVITY AND POLYPHENOL CONTENT OF AERIAL PARTS AND BULBS OF ALLIUM SCHUGNANICUM

S. Satorov1, F. Mirzoeva1, Sh. Kurbonbekova2, Sh. Satorov3, M. Vakhidova3, V. Dushenkov4

1Department of Microbiology, Immunology and Virology, Аvicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan
2Institute of Botany, Physiology and Genetics of Plants, National Academy of Sciences of Tajikistan, Dushanbe, Republic of Tajikistan
3Department of Plant Biology, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ, USA
4Department of Natural Sciences, Hostos Community College, City University of New York, Bronx, NY, USA

Objective: То study of antibacterial, antifungal and antioxidant activity, and content of polyphenols in the bulb and aerial parts of an endemic species of onion A. schugnanicum.

Methods: An ethanol-based extract was prepared from fresh plants. Total polyphenolic content (Folin) and ABTS antioxidant capacity assays were used to characterized extracts. Extracts obtained from bulbs, peduncle, and seeds demonstrated antibacterial activity against the reference Staphylococcus aureus (ATCC 4929), Pseudomonas aeruginosa (ATCC 4930) and Klebsiella pneumoniae (ATCC 4927) strains, as well as against the hospital strains of the same types of bacteria, i.e. strains isolated from inpatient surgical patients.

Results: The study found that ethanol extracts obtained from all organs of A. schugnanicum exhibit high inhibitory activity against the hospital and reference strains. In relation to reference then to hospital strains ethanol extracts were more active. The greatest bactericidal effect on both strains was exhibited by the bulb extracts. The extracts did not inhibit the growth of Escherichia coli. Fungicidal action characterized by growth inhibition zone of bulb and seeds, respectively. The extract obtained from the peduncle of this plant exhibited smaller inhibitory activity. The antioxidant capacity of A. schugnanicum different parts are shown in all the parts had a large antioxidant activity with dominating antioxidant capacity in seeds. The highest polyphenol level was found in the bulb.

Conclusion: The study showed that A. schugnanicum may be a prospective species for developing botanical therapeutics.

Keywords: Allium schugnanicum, medicinal plants, growth inhibition, extracts, antioxidant activity, hospital strains of bacteria, reference strains of bacteria.

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Authors' information:

Satorov Saidbeg
Doctor of Medical Sciences, Professor, Head of the Department of Microbiology, Immunology and Virology, Avicenna Tajik State Medical University
SCOPUS: 10419425154
Researcher ID: S-9073-2016
ORCID ID: 0000-0003-1101-1840
Author ID: 78634
SPIN: 2523-8682
E-mail: sattorion@mail.ru

Mirzoeva Fazila
Assistant, Department of Microbiology, Immunology and Virology, Avicenna Tajik State Medical University
ORCID ID: 0000-0003-0187-0334
E-mail: fazila.mirzoeva88@mail.ru

Kurbonbekova Shifo
Senior Researcher, Institute of Botany, Physiology and Genetics of Plants, National Academy of Sciences of the Republic of Tajikistan
ORCID ID: 0000-0001-7499-793x
E-mail: sh.k-biomed@yahoo.com

Satorov Shukhrat
Intern of the Department of Plant Biology, School of Environmental and Biological Sciences, Rutgers University
SCOPUS: 1742026179
ORCID ID: 0000-0003- 3072-1135
E-mail: sufion@mail.ru

Vakhidova Manizha
Intern of the Department of Plant Biology, School of Environmental and Biological Sciences, Rutgers University
ORCID ID: 0000-0002-3366-1580
SPIN: 9366-9702
E-mail: sufion@mail.ru

Dushenkov Vyacheslav
PhD, Associate Professor at the Department of Natural Sciences, Hostos Community College, City University of New York
SCOPUS: 6507356097
Researcher ID: AAE-8520-2019
ORCID ID: 0000-0001- 5176-7461
Author ID: 638952
SPIN: 50533-0988
E-mail: dushenkov@sebs.rutgers.edu

Information about support in the form of grants, equipment, medications

The authors did not receive financial support from manufacturers of medicines and medical equipment

Conflicts of interest: No conflict

Address for correspondence:

Satorov Saidbeg
Doctor of Medical Sciences, Professor, Head of the Department of Microbiology, Immunology and Virology, Avicenna Tajik State Medical University

734003, Republic of Tajikistan, Dushanbe, Rudaki Ave., 139

Tel.: +992 (987) 842424

E-mail: sattorion@mail.ru

Materials on the topic:
  1. IN VITRO EVALUATION OF ANTITHROMBOTIC AND ANTICOAGULANT ACTIVITY OF HERBAL SOURCES
  2. ANALYSIS OF ANTIBACTERIAL AND FUNGICIDAL ACTIVITY OF ALLIUM OSHANINII AND ALLIUM SUWOROWII DEPENDING ON THE ALTITUDE OF PLANT GROWTH
  3. STUDY OF ANTIBACTERIAL ACTIVITY OF EXTRACTS OF DIFFERENT SPECIES OF THE GENUS Allium GROWING IN TAJIKISTAN
  4. DEVELOPMENT OF THE COMPOSITION AND TECHNOLOGY OF COATED TABLETS WITH RHEUM CORDATUM LOSINSK. EXTRACT
  5. COMPARATIVE CHARACTERISTICS OF ANTIBACTERIAL ACTIVITY OF PLANTS GROWING IN THE CENTRAL PART OF THE REPUBLIC OF TAJIKISTAN
  6. ANTI-TUMOR ACTIVITY OF DRY EXTRACT PADUS GRAYANAE MAXIM IN VITRO
  7. ABOUT SIMPLE ANTI-DIABETIC REMEDIES BY AVICENNA
  8. ANTIOXIDANT ACTIVITY AND CONTENT OF POLYPHENOLS IN ARTEMISIA SCOPARIA WALDST. ET KIT., GROWING UNDER THE CONDITIONS OF WESTERN PAMIR
  9. MOLECULAR APPROACH TO DETERMINE THE HOT AND COLD TEMPERAMENTS IN PLANTS ACCORDING AVICENNA CONCEPTS, THE ROLE OF MAGNESIUM

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