OUTCOMES OF HBV-RELATED CHRONIC HEPATITIS IN CHILDREN

N.F. Faizulloev¹, N.M. Hojaeva²

¹Academy of Medical Sciences Ministry of Health and Social Protection of Population of the Republic of Tajikistan
²Chair of Pediatric Infectious Diseases Avicenna TSMU

The article presents the results of dispensary follow-up of 113 children with chronic hepatitis B and D. A direct correlation of currency CHB inchildren from the activity of the pathological process in the liver is established, the more higher activity, the more harder and longer disease occurs. Among the observed children with chronic hepatitis B clinical and morphological picture of liver cirrhosis and hepatocellular carcinoma were not identified in any case, despite the noticeable deviations in the liver in severe histological degree of pathological process activity. Established a high percentage of CHD in the structure of chronic HBsAg-positive liver disease (63,4%). In children with minimal activity CHD ascertained pathological process was in 24,5%, high activity – in 62,7% and in cirrhosis –in 13 (2,7%) patients. In CHD unlike CHB, in 80,4% of patients was observed an exacerbation of the pathological process. Persistent and prolonged increase ofhepatic aminotransferases depend on histological and morphological activity of liver. At the dispensary observation of patients with chronic viral hepatitis, along with the accepted algorithm of examination and observation, to predict adverse outcomes in these children it is important to determine the level of circulating immune complexes in the blood serum.

Keywords: chronic hepatitis, cirrhosis , hepatic biopsy.

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