FEATURES OF HUMORAL IMMUNITY AND PROTEIN-ELECTROLYTE HOMEOSTASIS IN CHILDREN WITH HYPOTROPHY

S.A. Rasulova, K.I. Ismoilov

Chair of Children Diseases №2 Avicenna TSMU

The results of research of humoral immunity state and protein and electrolyte homeostasis in 89 children (aged 2 months. Up to 2 years) for hypotrophy are presented. Depending underweight patients were divided into 3 groups.The levels of Ig A, M, G in serum of patients with I degree of hypotrophy is not much different from those in the group of healthy children (IgA – 3,98±0,13, p>0,05, IgM– 1,98±0,42, p>0,05, IgG– 13,0±0,51, p>0,05). Whereas in patients with II and III degree of hypotrophy found a marked decline in mean value of Ig A, M, G in serum as compared with the same indicators of the group of healthy children (hypotrophy II st.: IgA – 3,00±0,02, p<0,001; IgM– 1,74±0,08, p<0,01; IgG – 11,4±0,22, p<0,05), and patients with hypotrophyIII degree indicators of immunoglobulin Ig A, M, G in serum were significantly lower compared with the control group (IgA – 2,01±0,07, p<0,001; IgM– 1,32±0,06, p<0,001; Ig G – 9,01±0,84, p<0,01). In proteinogramof children with hypotrophy II and III degree found growing with hypoproteinemiawith dysproteinemia. The electrolyte homeostasis in children with moderate to severe hypotrophy showed a marked decrease in the concentration of K, Na, Ca and P ions, with dominate of K and Na (p<0,001 and p>0,05), respectively.

Keywords: hypotrophy, humoral immunity , protein-electrolyte homeostasis, hypoproteinemia.

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