doi: 10.25005/2074-0581-2016-18-1-72-76
Dynamics of changes in kallikrein-kinin and coagulation systems of blood in coronary heart disease

S.A. Muminjonov1, Sh.F. Odinaev, F.I. Odinaev, H.T. Faizullaev2, S.M. Boboaliev2

1Chair of internal diseases №1 Avicenna TSMU, CSRL
2Republican Clinical Center of Cardiology

Given the leading role of the kallikrein-kinin blood system in the genesis of myocardial ischemia its main components against the backdrop of cardiometabolic and kinin-stable therapy in 20 patients with post-infarction cardiosclerosis arestudied.

The results showed that ischemia and cardiosclerosis accompanied by increased levels of kallikrein to 15,3 nmol/L (control – 13,25 nmol/L) due to lowering of prekallikrein and kallikrein inhibitory capacities (α1-antitrypsin and α2-macroglobulin), with increased blood clotting.

Application of Contrical with cardiometabolic therapy help to stabilize of the kallikrein-kinin system of blood, as well as improve the rheological properties of blood. These conditions allow the use of kallikrein-kinin, and clotting system as evaluating the effectiveness of treatment and prognosis.

Keywords: coronary heart disease, the kallikrein-kinin system, myocardial post-infarction cardiosclerosis.

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