Diagnosis of HIV infection at perinatal stages and in newborns

R.Sh. Ashurova, N.M. Khojaeva, R.A. Tursunov, N.S. Juraeva

Chair of Pediatric Infectious Diseases Avicenna TSMU

Review of the literature is devoted to analysis of effective methods of diagnosis of HIV infection in children in the prenatal and postnatal periods. Perinatal transmission of HIV from mother to child is the leading mechanism in childhood, therefore, extremely important to test a mother for HIV, and promptly begin preventive treatment.

Analysis of published data shows that for the purpose of early diagnosis of HIV infection in children with confirmed perinatal HIV-status tests for the HIV virus is recommended at the age of 14-21 days, 1-2 months and 4-6 months. It is also necessary to test for HIV at birth the children with a high risk of HIV infection during vaginal delivery. With this view for early diagnosisamong virological methods the most preferred is polymerase chain reaction for the detection of DNA of HIV in peripheral blood lymphocytes and RNA of HIV – in plasma.

From retrospective assessment of the quality care of the child and to provide information for the disease prognosis and possible complications it is important to carry out laboratory monitoring of children with confirmed HIV status.

Keywords: HIV infection, perinatal period , newborn period, diagnosis of HIV in children.

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