Summary
doi: 10.25005/2074-0581-2014-16-4-38-44
Pathogenesis and treatment of endothelial dysfunction in suppurative cholangitis
Chair of Surgical Diseases №1 Avicenna TSMU
The authors analyzed the results of a comprehensive diagnosis and surgical treatment of 120 patients with suppurative cholangitis. A study of markers of endothelial dysfunction in severe acute suppurative cholangitis (n=32) and biliary sepsis (n=24) showed a significant their increase due endotoxin aggression caused by cholangiogenic infection and oxidative stress. Depending on the general condition of patients, the severity of endotoxin aggression and bilirubinemia one- and two-stage treatment with using of modern technology and traditional surgical procedures were performed. Due to severity of endotoxemia and the general condition 61of patients underwent two-stage surgery.
Along with biliary decompression, eliminating the causes of obstruction, pathogenetically substantiated treatment of endothelial dysfunction in suppurative cholangitis is intraportal and
transcholedoheal introduction of antihypoxants and antioxidants (n=24). In the postoperative period, after the complex pathogenetic treatment in 11 (9%) cases observed deaths, the cause of which was progressive liver failure in 8 cases and – acute cardiovascular failure – in 3.
Keywords: suppurative cholangitis, endotoxin aggression, decompression of the bile duct, oxidative stress, endothelial dysfunction.
Materials on the topic:
- Surgical treatment of idiopathik scared stenose of trachea
- Clinical - immunological disorders in urogenital chlamydiosis in men
- Evaluation of medication «Corvitin» in complex treatment of patients with acute myocardial infarction
- Prevalence of liver cirrhosis in Tajikistan
- Results of therapy patients in acute stage of HIV infection among prisoners
- Analysis of pregnant women morbidity, such as research microelement status of women's population living in districts of town Lipetsk with different atnropotehnogenic load
- Hormonal and metabolic concept of pathogenesis prostate diseases
- MEDICINES INFLUENCING ON REGENERATION OF PERIPHERIAL NERVES
- ABDOMINOPLASTICS IN PATIENTS WITH POSTOPERATING SCARS OF FRONT ABDOMENWALL
- PROCESS OF RECANALIZATION IN YEARLY PERIOD AFTER ACUTE TROMBOPHLEBITIS OF DEEP VEINS OF LOW EXTREMITIS