Features of diagnosis and treatment of mutual aggravation syndrome in patients with diabetes septic complications in the highlands

Sh.Yu. Yusupova, D.A. Abdulloev, M.H. Nabiev, U.M. Begakov

Chair of General Surgery №2 Avicenna TSMU

The study is based on an analysis of examination and treatment outcomes in 110 patients with purulent-septic complications of diabetes mellitus (PSC DM) in the highlands and valleys.

Studies have shown that at high altitude there is an increased content of products of lipid peroxidation (LPO) – malondialdehyde (MDA) in plasma of patients with diabetes PSC DM, while MDA increased to 6,3±1,25, DC – 0,92±0,14, and at common septic processes in these patients MDA reaches a critical level – 7,82±0,92 m / ml; DC – 1,24±0,05 um / ml, which is significantly higher compared with MDA and DC plasma (5,9±1,23 mm / mL, DC – 0,90±0,32 um / ml ) in a valley. At the same time noted a direct correlation between the intensity of lipid peroxidation and the severity of purulent-necrotic process.

With the progression of the pathological process and LPO activation the excessive amount of disturbed metabolism products, intermediates and end products of LPOappears in the blood with toxic effect, which leads to cell damage and their death. But the most important reason may be the antioxidant deficiency growing, which confirms the positive effect of antioxidants during using of which oxidative stress is not generated.

Keywords: purulent-septic complications of diabetes, lipid peroxidation, Mexidol.

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