ROLE IN VIRAL PRECANCEROUS AND NEOPLASTIC PROCESS ESOPHAGUS IN RESIDENTS OF MONGOLIA

H. Gerelee, V.V. Baykov, M. Tuul

Study investigates the role of viruses in precancerous and neoplastic processes of the esophagus in people of Mongolia.

The results obtained that herpes simplex virus (HSV), Epstein-Barr virus (EBV) and human papilloma virus (HPV) infection are participate in the pathogenesis of esophageal cancer. Using polymerase chain reaction from histologic preparations showed that the positive results: at 1.2 HSV types predominated in all forms of carcinomas, except for squamous cell carcinoma of low differentiation, with EBV in undifferentiated carcinoma and squamous cell carcinoma of high and moderate degree of differentiation, with HPV identified with varying degrees of intraepithelial neoplasia and squamous cell carcinoma of moderate differentiation.

In the precancerous processes of the overall percentage of positive result of all viruses was 11.4%, and in neoplastic processes - 22.8%, ie in exactly 2 times more HSV grown in 1,5 times, VEB - 7 times, the percentage of HPV has not changed.

The authors believe that a high percentage of HSV in precancerous and neoplastic processes of the esophagus may be one of the etiological markers in the development of esophageal cancer in Mongolia.

Keywords: precancerous and neoplastic processes in the esophagus, the herpes simplex virus, EpsteinBarr virus, human papilloma virus.

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