REVIEW ARTICLE
Dentistry
doi: 10.25005/2074-0581-2026-28-1-174-189
INFLAMMATORY AGING OF THE PERIODONTIUM

D.A. MOISEEV, I.S. KOPETSKIY

Pirogov Russian National Research Medical University, Moscow, Russian Federation

Objective: To summarize the available data and analyze previously conducted studies on the mechanisms and features of the development of inflammatory aging, as well as to formulate approaches to the correction of conditions associated with inflammatory aging of the periodontium.

Methods: A systematic review of the literature was conducted. A total of 15,896 publications indexed in international electronic databases were identified, including PubMed, Google Search, Ebsco, Embase, Web of Science, ScienceDirect, SciELO, and eLibrary. Based on the developed selection criteria, 67 publications were included that reported on mechanisms and features of inflammatory aging in general and of periodontal tissues in particular, as well as on modern technologies aimed at correcting inflammatory manifestations in the periodontium. The methodology of this study complies with the PRISMA guidelines for systematic reviews and meta-analyses.

Results: The study analyzed and summarized findings on the mechanisms and clinical features of inflammatory aging. Particular attention was paid to the development of inflammatory aging in periodontal tissues. Technologies that may become promising tools for personalized preventive correction of conditions associated with inflammatory aging of the periodontium and oral cavity were identified.

Conclusion: Inflammatory aging is one of the “main causes” underlying aging phenotypes. This systematic review demonstrates a general imbalance in inflammatory processes that gradually shifts with age toward enhanced inflammation and impaired anti-inflammatory mechanisms.

Keywords: Aging, inflammatory aging, oral aging, periodontal aging, age-related changes.

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Authors' information:

Moiseev Denis Aleksandrovich,
Candidate of Medical Sciences, Head of the Laboratory of Simulation Technologies in Dentistry, Associate Professor of the Department of Therapeutic Dentistry, Institute of Dentistry, Pirogov Russian National Research Medical University
Researcher ID: KIC-6665-2024
Scopus ID: 58534020500
ORCID ID: 0000-0001-7811-7741
SPIN: 2017-4416
Author ID: 943246
E-mail: moiseeff.den@yandex.ru

Kopetskiy Igor Sergeevich,
Doctor of Medical Sciences, Full Professor, Head of the Department of Therapeutic Dentistry, Director of the Institute of Dentistry, Pirogov Russian National Research Medical University
ORCID ID: 0000-0002-4723-6067
SPIN: 8813-9525
Author ID: 588033
E-mail: kopetski@rambler.ru

Information about support in the form of grants, equipment, medications

The author did not receive financial support from manufacturers of medicines and medical equipment

Conflicts of interest: No conflict

Address for correspondence:

Moiseev Denis Aleksandrovich,
Candidate of Medical Sciences, Head of the Laboratory of Simulation Technologies in Dentistry, Associate Professor of the Department of Therapeutic Dentistry, Institute of Dentistry, Pirogov Russian National Research Medical University

117513, Russian Federation, Moscow, Ostrovityaninov str, 1, bld. 7

Tel.: +7 (915) 7293911

E-mail: moiseeff.den@yandex.ru


This work is licensed under a Creative Commons Attribution 4.0 International License.

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