Ophthalmology
doi: 10.25005/2074-0581-2024-26-4-654-666
OCULAR CHANGES DURING PREGNANCY
1Department of Ophthalmology, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan
2Department of Obstetrics and Gynecology № 1, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan
This article reviews current data on physiologic and pathological ocular changes related to pregnancy. Generally, eye complications during pregnancy tend to be mild, temporary and do not require treatment. However, some complications can be severe and necessitate immediate ophthalmological intervention. Research on the visual system during pregnancy indicates that all eye structures change, regardless of previous conditions. Moreover, some physiological changes might progress into pathological conditions, causing preexisting diseases such as diabetic retinopathy, myopia, and glaucoma to worsen during pregnancy and require medical attention. Unfortunately, there is a lack of research in the Republic of Tajikistan regarding the relationship between eye health and pregnancy, highlighting the importance of studying this issue with regional considerations. A literature review was conducted using international electronic databases, such as PubMed and Google Scholar, and Russian scientific electronic libraries, such as CyberLeninka and Elibrary.ru, covering the last 10 years. Over 1,500 articles were found, and 33 relevant sources were selected based on specific keywords. Articles about eye diseases unrelated to pregnancy and congenital eye pathologies were excluded from the review.
Keywords: Ophthalmology, fundus, eye diseases, retinal detachment, pregnancy, preeclampsia.
References
- Sinchikhin SP, Ramazanova LSh, Stepanyan LV, Napylova OA, Khanmirzoeva SKh. Patologiya organov zreniya u beremennykh zhenshchin [Pathology of visual organs in pregnant women]. Arkhiv akusherstva i ginekologii im. V.P. Snegiryova. 2019;6(2):60-9. https://doi.org/10.18821/2313-8726-2019-6-2-60-69
- Naderan M, Jahanrad A. Topographic, tomographic and biomechanical corneal changes during pregnancy in patiens with keratoconus: A control study. Acta Ophthalmology. 2017;95(4):291-5. https://doi.org/10.1111/aos.13296
- Rezai S, LoBue S, LoBue TD. Ophthalmic complications and ocular changes in pregnancy – A review. Obstetrics Gynecology International Journal. 2016:4(1):00093.
- Matnenko TYu, Barinov SV, Chulovskiy YuI, Lebedev OI, Storozhenko AA, Shmik RV. Oftal'mologicheskie narusheniya pri gipertenzivnykh oslozhneniyakh beremennosti [Ophthalmologic disorders in hypertensive complications of pregnancy]. Mat' i ditya v Kuzbasse. 2023;1:12-9. https://doi.org/10.24412/2686- 7338-2023-192-12-19
- Stern EN, Blace N. Ophthalmic pathology оf preeclampsia. StatPears[Internet]: Treasure Island (FL): StatPearis Publishing. 2024. PMID: 35015414
- Naderan M. Ocular changes during pregnancy. J Current Ophthalmology. 2018;30(3):202-10. https://doi.org/10.1016/j.joco.2017.11.012
- Sethi HS, Naik M, Gupta VS. Management glaucoma in pregnancy: Risks or choices, a dilemma? Int J Ophthalmol. 2016;9(11):1684-90. https://doi. org/10.18240/ijo.2016.11.24
- Kra ANS, Kouassi FX, Koman CE, Soumahoro M, Sowagnon TYC, Ouffoue YG. Central serous chorioretinopathy and pregnancy: A case report. Open J Ophthalmol. 2018;8:207-213. https://doi.org/10.4236/ojoph.2018.84024
- Ochinciuc R, Munteanu M, Baltă G, Baltă F. Central serous chorioretinopathy in pregnancy. Rom J Ophthalmol. 2022;66(4):382-5. https://doi.org/10.22336/ rjo.2022.68
- Krasnoshchyokova EE, Boyko EV, Shadrichev FE. Evolyutsiya vzglyadov na vybor metoda rodorazresheniya v zavisimosti ot sostoyaniya glaznogo dna u beremennykh s perifericheskimi vitreokhorioretinal'nymi distrofiyami i regmatogennoy otsloykoy setchatki [Evolution of views on the choice of the method of delivery depending on the state of the ocular fundus in pregnant women with peripheral vitreochorioretinal dystrophies and rhegmatogenous retinal detachment]. Oftalmologicheskie vedomosti. 2011;4(2):62-8.
- Alishunin LV, Danilov OV. Osobennosti mikrotsirkulyatsii v perifericheskikh otdelakh setchatki u lits s miopiey, sochetayushcheysya s vitreokhorioretinal'noy degeneratsiyami [Features of microcirculation in the peripheral retina in subjects with myopia combined with vitreochorioretinal degeneration]. Sovremennye tekhnologii v oftal'mologii. 2014;2:94-6.
- Alishunin LV. Sostoyanie mikrotsirkulyatsii perifericheskikh otdelov setchatki i sosudistoy obolochki glaza u beremennykh [State of microcirculation of peripheral retina and ocular vasculature in pregnant women]. Tikhookeanskiy meditsinskiy zhurnal. 2015;3:72-3.
- He X, Ji Y, Yu Me, Tong Y. Chorioretinal alterations induced by preeclampsia. J Ophthalmol. 2021;2021:8847001. https://doi.org/10.1155/2021/8847001
- Naderan M, Sabzevary M, Rezaii K, Banafshehafshan A, Hantoushzadeh S. Intravitreal anti-vascular endothelial growth factor medications during pregnancy: current perspective. Int Ophthalmol. 2021;41(2):743-51. https://doi. org/10.1007/s10792-020-01610-2
- Belotserkovtseva LD, Kovalenko LV, Pankratov VV, Zinin VN. Rannyaya preeklampsiya i vozmozhnost' prolongirovaniya beremennosti s tochki zreniya patogeneticheskogo podkhoda [Early preeclampsia and the possibility of prolonging pregnancy from a pathogenetic approach]. Obshchaya reanimatologiya. 2022;18(2):37-44. https://doi.org/10.15360/1813-9779-2022-2-37-44
- Poon LC, Magee LA, Veriohren S, Shennan A, Von Dadelszen P, Sheiner E, et al. A literature review and the best practice advice for second and third trimester risk stratification, monitoring and management of pre-eclampsia. Int J Obstet Gynecol. 2021;154(51):3-31. https://doi.org/10.1002/ijgo.13763
- Rana S, Lemoine E, Granger JP, Karumanchi S. Preeclampsia: Pathophysiology, challenges, and perspectives. Circ Res. 2019;124(7):1094-112. https://doi. org/10.1161/CIRCRESAHA.118.313276
- Vagel S, Cohen SM, Goldman-Wohl D. An integrated model of preeclampsia: A multifaseted syndrome of the maternal cardiovascular-placental-fetal array. Am J Obstet Gynecol. 2022;226(25):5963-72. https://doi.org/10.1016/j. ajog.2020.10.023
- Moss HE. Neuro-ophthalmology and pregnancy. Continuum (Minneap Minn). 2022;28(1):147-61. https://doi.org/10.1212/CON.0000000000001059
- Nagy ZZ. Review of the ophthalmic symptoms of preeclampsia. DHS. 2020;3(1):21-3. https://doi.org/10.1556/2066.2020.00005
- Qin Q, Chen C, Cugati S. Ophthalmic associations in pregnancy. AJGP. 2020;40(10):673-80. https://doi.org/10.31128/AJGP-10-19-5113
- Soma-Pillay P, Pillay R, Wong TY, Makin JD, Pattinson RC. The effect of pre-eclampsia on retinal microvascular caliber at delivery and post-partum. Obstet Med. 2018;11(3):116-20. https://doi.org/10.1177/1753495X17745727
- Ge G, Zhang Y, Zhang M. Pregnancy-induced hypertension and retinopathy of prematurity: A meta-analysis. Acta Ophthalmol. 2021;99(8):e1263-e1273. https://doi.org/10.1111/aos.14827
- Vlasov TD, Nesterovich II, Shimanskiy DA. Endotelial'naya disfunktsiya: ot chastnogo k obshchemu. Vozvrat k «staroy paradigme»? [Endothelial dysfunction: From particular to general. A return to the “old paradigm”?]. Regionarnoe krovoobrashchenie i mikrotsirkulyatsiya. 2019;18(2):19-27. https://doi. org/10.24884/1682-6655-2019-18-2-19-27
- Kolenko OV, Sorokin EL, Fil AA, Pomytkina NV. Sosudistye oslozhneniya glaza v otdalyonnye sroki posle perenesyonnoy preeklampsii [Vascular complications of the eye in the distant period after pre-eclampsia]. Oftal'mokhirurgiya. 2020;1:77-82. https://doi.org/10.25276/0235-4160-2020-1-77-82
- Auger N, Fraser W, Paradis G, Healy-Profitos J, William D. Preeclampsia and the risk of cataract extraction in life. American Journal of Obstetrics and Gynecology. 2017;216(4):417. https://doi.org/10.1016/j.ajog.2016.11.1043
- Kolenko OV, Sorokin EL, Khodzhaev NS, Pomytkina NV, Chizhova GV, Pashentsev YaE, i dr. Rol' gestatsionnoy arterial'noy gipertenzii i preeklampsii kak faktorov riska formirovaniya sosudistoy patologii setchatki v otdalyonnye sroki posle rodov [The role of gestational arterial hypertension and preeclampsia as risk factors for the formation of retinal vascular pathology in the distant postpartum period]. Oftal'mologiya. 2020;17(3):389-97. https://doi.org/10.18008/1816- 5095-2020-3-389-397
- Evcimen Y, Onur IU, Cengiz H, Yigit FU. Choroidal thickness in preeclampsia. Curr Eye Res. 2020;45(2):228. https://doi.org/10.1080/02713683.2019.16734 35
- Lee CS, Choi EY, Lee M, Kim H, Chung H. Serous retinal detachment in preeclampsia and malignant hypertension. Eye (Lond). 2019;33(11):1707-14. https://doi.org/10.1038/s41433-019-0461-8
- Gonser M, Vonzun L, Ochsenbein-Kolble N. Ophthalmic artery Doppler in prediction of pre-eclampsia: Шnsights from hemodynamic considerations. Ultrasound Obstet Gynecol. 2021;58(1):145-7. https://doi.org/10.1002/uog.23665
- Brusse IA, Van den Berg CB, Duvekot JJ, Cipolla MJ, Steegers EAP, Visser GH. Visual evoked potentials in women with and without preeclampsia during pregnancy and postpartum. J Hypertens. 2018;36(2):319-25. https://doi. org/10.1097/HJH.0000000000001521
- Riva CE, Geiser M, Petrig BI. Ocular blood flow assessment using continuous laser Doppler floumetry. Acta Ophthalmology. 2010;88(6):622-9. https://doi. org/10.1111/j.1755-3768.2009.01621.x
- Rzeszotarska A, Szczapa-Jagustyn J, Kociecki J. Ophthalmological problems in pregnancy – a review. Ginekol Pol. 2020;91(8):473-7. https://doi.org/10.5603/ GP.2020.0080
Authors' information:
Gulakhmadova Shakhnoz Bakhtiyorovna,
Postgraduate Student of the Department of Ophthalmology, Avicenna Tajik State Medical University.
ORCID ID: 0009-0001-3736-4479
E-mail: dr_shakhoz87@mail.ru
Dodkhoeva Munavvara Fayzulloevna,
Academician of NAST, Doctor of Medical Sciences, Full Professor, Professor of the Department of Obstetrics and Gynecology № 1, Avicenna Tajik State Medical University
Researcher ID: AAC-4784-2019
ORCID ID: 0000-0001-9373-4318
SPIN-код: 9749-6174
Author ID: 313026
E-mail: dodkho2008@mail.ru
Makhmadzoda Shamsullo Kurbon,
Candidate of Medical Sciences, Associate Professor, Head of the Department of Ophthalmology, Avicenna Tajik State Medical University
ORCID ID: 0000-0001-8292-8344
E-mail: shamsullo-@mail.ru
Information about support in the form of grants, equipment, medications
The authors did not receive financial support from manufacturers of medicines and medical equipment
Conflicts of interest: No conflict
Address for correspondence:
Dodkhoeva Munavvara Fayzulloevna
Academician of NAST, Doctor of Medical Sciences, Full Professor, Professor of the Department of Obstetrics and Gynecology № 1, Avicenna Tajik State Medical University
734026, Republic of Tajikistan, Dushanbe, Sino str., 29-31
Tel.: +992 (918) 612606
E-mail: dodkho2008@mail.ru
This work is licensed under a Creative Commons Attribution 4.0 International License.
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