doi: 10.25005/2074-0581-2020-22-1-56-60

N.A. Zaripov, M.T. Ganieva

Department of Neurology and Basics of Medical Genetics, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan

Objective: To study cognitive changes in patients with akinetic-rigid and tremor-dominant Parkinson’s disease (PD).

Methods: From January to May 2019 were examined and responded 32 patients with akinetic-rigid (n=15; 46.9%) and tremor-dominant (n=17; 53.1%) PD. The average age of the patients was 66.5±3.7 years. All patients of PD before and after receiving appropriate therapy were responded using the MMSE (Mini-Mental State Examination) scale to detect the possible cognitive dysfunctions. The study of cognitive functions in patients was conducted before the start of therapy, as well as 3 months after treatment.

Results: At the admission, cognitive disorders were more significant in akinetic-rigid PD than in a tremor-dominant PD. After 3 months of appropriate therapy, cognitive dysfunction rates in patients with akinetic-rigid PD improved significantly (p<0.001) in compare to tremor-dominant PD (p<0.05).

Conclusions: Using the MMSE scale helps to detect and determine the severity of cognitive changes in a timely manner and the risk of further development of dementia in patients with PD, that allows to start corrective activities in time. Timely detection and appropriate approach to the treatment of the underlying disease and the correction of cognitive impairment significantly improves the quality of life of patients themselves, contributes reducing economic costs.

Keywords: Parkinson’s disease, cognitive disorders, akinetic-rigid and tremor-dominant Parkinson’s disease, MMSE scale.

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Authors informations:

Zaripov Nurali Abdurakibovich
PhD Student, Department of Neurology and Basics of Medical Genetics, Avicenna Tajik State Medical University
ORCID ID: 0000-0001-5494-1218

Ganieva Manizha Temurovna
Candidate of Medical Sciences, Head of the Department of Neurology and Basics of Medical Genetics, Avicenna Tajik State Medical University
Researcher ID: E-4389-2019
ORCID ID: 0000-0001-5865-8954

Information about the source of support in the form of grants, equipment, and drugs

The authors did not receive financial support from manufacturers of medicines and medical equipment

Conflict of interest: No conflict

Address for correspondence:

Zaripov Nurali Abdurakibovich
PhD Student, Department of Neurology and Basics of Medical Genetics, Avicenna Tajik State Medical University

734003, Republic of Tajikistan, Dushanbe, Rudaki Ave., 139

Tel.: +992 (987) 329015


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