ORIGINAL RESEARCH
Neurology
doi: 10.25005/2074-0581-2025-27-2-306-316
POTENTIAL APPLICATION OF HAWTHORN IN NEUROLOGY

S.R. KHASANOVA1, N.V. KUDASHKINA1, A.V. SAMORODOV2, V.A. KURKIN2, A.V. DUBISHCHEV2, N.A. ZARIPOV3

1Bashkir State Medical University, Ufa, Russian Federation
2Samara State Medical University, Samara, Russian Federation
3Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan

Objective: To assess the antioxidant, anticoagulant, and antiplatelet properties of various species from the genus Crataegus L. and to select the most promising candidates for neurological applications.

Methods: : The study utilized the shoots and berries of six introduced species from the genus Crataegus L. and one wild species. The species examined included: 1. Crataegus pennsylvanica Ashe (Pennsylvania hawthorn) 2. Crataegus almaatensis Pojark (Almaty hawthorn) 3. Crataegus rivularis Nutt. (River hawthorn) 4. Crataegus submollis Sarg. (Soft-leaved hawthorn) 5. Crataegus prunifolia (Poir.) Pers. (Plum-leaved hawthorn) 6. Crataegus macracantha Lodd. ex Loudon (Large-thorned hawthorn) 7. A wild species, Crataegus sanguinea Pall (Red hawthorn) Two variations of chemiluminescence tests were employed to evaluate these species' antioxidant activity (AOA) and quantify the decrease in light emission. The anticoagulant properties were assessed through coagulation tests, while Born's optical platelet aggregometry was utilized to determine antiplatelet activity. All experimental data obtained were statistically analyzed.

Results: The highest AOA levels were found in the berries and shoots of C. almaatensis, C. sanguinea, and C. submollis. The most significant effects on the plasma component of the hemostasis system were noted in the berries of C. sanguinea, C. submollis, C. rivularis, and the shoots of C. macracantha. In assessing antiplatelet (AP) effects, the highest measurements were recorded in the berries and shoots of C. submollis, C. sanguinea, C. rivularis, and C. almaatensis.

Conclusion: The berries of C. amanuensis and the berries and shoots of C. sanguinea, C. submollis, and C. rivularis are the most promising species for further research and development of effective herbal medicines for use in neurology.

Keywords: The genus Crataegus L., oxidative stress, antioxidant activity, chemiluminescence, anticoagulant properties, antiplatelet properties, Born method.

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Authors' information:

Khasanova Svetlana Rashitovna,
Doctor of Pharmaceutical Sciences, Full Professor, Professor of the Department of Pharmacognosy and Botany, Bashkir State Medical University
Researcher ID: DWR-9689-2022
Scopus ID: 57212514163
ORCID ID: 0000-0001-7000-8014
SPIN: 7027-0676
Author ID: 465615
E-mail: svet-khasanova@yandex.ru

Kudashkina Nataliya Vladimirovna,
Doctor of Pharmaceutical Sciences, Full Professor, Head of the Department of Pharmacognosy and Botany, Bashkir State Medical University
Researcher ID: Q-1655-2015
Scopus ID: 57207299733
ORCID ID: 0000-0002-0280-143Х
SPIN: 4256-5502
Author ID: 637292
E-mail: phytoart@mail.ru

Samorodov Aleksandr Vladimirovich,
Doctor of Medical Sciences, Associate Professor, Head of the Department of Pharmacology, Bashkir State Medical University
Researcher ID: Y-7188-2018
Scopus ID: 55797058900
ORCID ID: 0000-0001-9302-499X
SPIN: 2396-1934
Author ID: 839168
E-mail: avsamorodov@gmail.com

Kurkin Vladimir Aleksandrovich,
Doctor of Pharmaceutical Sciences, Full Professor, Head of the Department of Pharmacognosy with Botany and the Basics of Phytotherapy, Samara State Medical University
Researcher ID: L-7663-2015
Scopus ID: 25023727600
ORCID ID: 0000-0002-7513-9352
SPIN: 1974-5537
Author ID: 55891
E-mail: v.a.kurkin@samsmu.ru

Dubishchev Aleksey Vladimirovich,
Doctor of Medical Sciences, Full Professor, Professor of the Department of Pharmacology, Samara State Medical University
Researcher ID: ERQ-9809-2022
Scopus ID: 66601961134
ORCID ID: 0000-0002-4430-6672
SPIN: 8511-0469
Author ID: 528082
E-mail: a.v.dubishchev@samsmu.ru

Zaripov Nurali Abdurakibovich,
PhD, Assistant of the Department of Neurology, Psychiatry and Medical Psychology named after Professor M.G. Gulyamov, Avicenna Tajik State Medical University
ORCID ID: 0000-0001-5494-1218
SPIN: 8489-6082
Author ID: 1054132
E-mail: nur.tj-94@mail.ru

Information about support in the form of grants, equipment, medications

The research was carried out in accordance with the research plan of Bashkir State Medical University (state registration number – АААА-А20-200011090030-9) and research plan of Samara State Medical University (state registration number – АААА-А19-119051490148-7). The authors did not receive financial support from manufacturers of medicines and medical equipment

Conflicts of interest: No conflict

Address for correspondence:

Khasanova Svetlana Rashitovna
Doctor of Pharmaceutical Sciences, Full Professor, Professor of the Department of Pharmacognosy and Botany, Bashkir State Medical University

450008, Russian Federation, Ufa, Lenin str., 3

Tel.: +7 (347) 2724173

E-mail: svet-khasanova@yandex.ru


This work is licensed under a Creative Commons Attribution 4.0 International License.

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