INTERPLAY BETWEEN GUT MICROBIOTA AND NEURODEGENERATION

REVIEW ARTICLE

Neurology

doi: 10.25005/2074-0581-2026-28-1-162-173

INTERPLAY BETWEEN GUT MICROBIOTA AND NEURODEGENERATION

F.A. YUSUPOV, M.SH. ABDYKADYROV

Osh State University, Medical Faculty, Osh, Republic of Kyrgyzstan

This review article analyzes current research aimed at elucidating the role of the gut microbiota in maintaining overall body homeostasis. It examines the influence of the microbiota on the pathogenesis of neurodegenerative diseases (NDDs), focusing on the molecular and mechanistic aspects of its interactions with the central nervous system (CNS) via the gut-brain axis. The goal of this review is to identify key mechanisms by which the microbiota influences neurological function and contributes to the development of NDDs.

The study provides a detailed analysis of neurochemical signaling, immunomodulation, and metabolic activity, all of which significantly influence neuroprotective mechanisms and the regulation of the inflammatory response. This approach provides a deeper understanding of how a balanced microflora supports optimal CNS function.

Analysis of experimental data demonstrates that dysbiosis – an imbalance of microflora – contributes to systemic and neuroinflammation, which may predetermine the development of neurological disorders such as Parkinson's disease, Alzheimer's disease, and other neurodegenerative conditions. This review highlights the need for further multidisciplinary research to clarify these influences and open new horizons for personalized diagnostic and therapeutic methods.

A search of scientific publications was conducted using the international databases Google Scholar, Scopus, PubMed, Cochrane, and Web of Science. The review primarily included papers published between 2015 and 2025, ensuring the most recent research was considered. Search terms included various combinations of keywords such as "gut microbiota", "neurodegenerative diseases", "gut-brain axis", "short-chain fatty acids", and "dysbiosis".

Keywords: Intestinal microbiota, gut-brain axis, neurodegenerative diseases, dysbiosis, short-chain fatty acids, Parkinson's disease, Alzheimer's disease.

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Authors' information:

Yusupov Furkat Abdulakhatovich,
Doctor of Medical Sciences, Full Professor, Head of the Department of Neurology, Neurosurgery and Psychiatry, Medical Faculty, Osh State University
Scopus ID: 57194719351
ORCID ID: 0000-0003-0632-6653
SPIN: 7415-1629
Author ID: 1047873
E-mail: furcat_y@mail.ru

Abdykadyrov Mukhammadyusuf Shkuratovich,
Assistant Professor of the Department of Neurology, Neurosurgery, and Psychiatry, Medical Faculty, Osh State University
Researcher ID: LMP-2727-2024
Scopus ID: 59677073200
ORCID ID: 0000-0001-5549-3832
SPIN: 5384-7010
Author ID: 1116061
E-mail: aratingo@mail.ru

Information about support in the form of grants, equipment, medications

The author did not receive financial support from manufacturers of medicines and medical equipment

Conflicts of interest: No conflict

Address for correspondence:

Abdykadyrov Mukhammadiusuf Shkuratovich
Assistant Professor of the Department of Neurology, Neurosurgery, and Psychi- atry, Medical Faculty, Osh State University

723500, Republic of Kyrgyzstan, Osh, Lenina str., 320

Tel.: +996 (999) 565637

E-mail: aratingo@mail.ru

This work is licensed under a Creative Commons Attribution 4.0 International License.

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