ORIGINAL RESEARCH

Neurology

doi: 10.25005/2074-0581-2022-24-4-442-451
NEUROPSYCHOLOGICAL PROFILE IN PATIENTS WITH HYPERTENSIVE ENCEPHALOPATHY IN THE BACKGROUND OF RESISTANT ARTERIAL HYPERTENSION

KH.YO. Sharipova1, F.N. Abdulloev2, R.G. Sokhibov3, D.D. Rakhimov1, R.M. Gulova1, G.M. Negmatov4

1Department of Propaedeutics of Internal Diseases, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan
2City Medical Center № 2 named after Academician K.T. Tadzhiev, Dushanbe, Republic of Tajikistan
3Department of Internal Diseases № 2, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan
4Department of Internal Diseases № 1, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan

Objective: To assess the severity of CI in relation to the level of RDR to antihypertensive therapy in patients with primary arterial hypertension (AH) and the features of CI on the background of RAH.

Methods: A complex of modern clinical, hemodynamic and neuropsychological methods was used to assess RDR to treatment and the severity of CI in groups of patients with high and very high RDR to treatment: the group I – with controlled arterial hypertension (CAH; n=40), the group II – with RAH (n=35).

Results: When screening for CI on the Montreal Cognitive Assessment (MoCA) scale, a decrease in the average number of various domains of cognitive function in patients with CAH was found against the background of increased RDR to treatment compared with RAH. The results of the neurodynamic analysis of cognitive function in the Trail Making Test (TMT) indicate the relative sustain of selective attention and information processing speed. However, the established increase in the difference between the part B and part A performance in patients with AH demonstrated a decline in flexible thinking, cognitive control, and programming. The results of the study of regulatory functions showed that frontal dysfunction was observed more often in patients of group II, although the difference was statistically insignificant (p>0.05). Based on the results of speech studies, along with the results of memory impairment testing in the Clock Drawing (CDT) and Free and Cued Selective Reminding – Immediate Recall (FCSRT-IR) tests, a more pronounced decline of semantic memory was found in patients with RAH, indicating the possibility of memory impairment not only due to secondary neurodynamic changes but also due to the neurodegenerative processes.

Conclusion: A significant decrease in semantic memory in patients with RAH suggests the possibility of the transformation of cerebral vascular lesions into neurodegenerative ones or their combination.

Keywords: Neuropsychological profile, cognitive impairment, hypertensive encephalopathy, risk of developing resistance to treatment, resistant arterial hypertension.

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Author information:


Sharipova Khursand Yodgorovna
Doctor of Medical Sciences, Full Professor, Professor of the Department of Propaedeutics of Internal Diseases, Avicenna Tajik State Medical University
ORCID ID: 0000-0001-9340-5215
SPIN: 5685-9944
Author ID: 846918
E-mail: sharipovakh@mail.ru

Abdulloev Firdavs Nazirovich
Resident of the Department of Neurology, City Medical Center № 2 named after Academician K.T. Tadzhiev
ORCID ID: 0000-0001-8622-9831
E-mail: abduloevfirdavs01@gmail.com

Sokhibov Rakhmatullo Gulomovich
Candidate of Medical Sciences, Head of the Department of Internal Diseases № 2, Avicenna Tajik State Medical University
ORCID ID: 0000-0002-2413-9299
E-mail: rahmatulosokhibovgmail.com

Rakhimov Dzhasur Dzhumaboevich
Postgraduate Student of the Department of Propaedeutics of Internal Diseases, Avicenna Tajik State Medical University
ORCID ID: 0000-0003-3376-1722
E-mail: jasur5000@yandex.ru

Gulova Rukhshona Makhmadshoevna
Postgraduate Student of the Department of Propaedeutics of Internal Diseases, Avicenna Tajik State Medical University
ORCID ID: 0000-0002-4695-223X
E-mail: komron909@mail.ru

Negmatova Gulnora Mansurovna
Candidate of Medical Sciences, Assistant of the Department of Internal Diseases № 1, Avicenna Tajik State Medical University
ORCID ID: 0000-0002-8309-3999
E-mail: gulya3663@mail.ru

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The authors did not receive financial support from manufacturers of medicines and medical equipment

Conflicts of interest: No conflict

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Sharipova Khursand Yodgorovna
Doctor of Medical Sciences, Full Professor, Professor of the Department of Propaedeutics of Internal Diseases, Avicenna Tajik State Medical University

734003, Republic of Tajikistan, Dushanbe, Rudaki Ave., 139

Tel.: +992 (935) 811297

E-mail: sharipovakh@mail.ru

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