Cardiology
doi: 10.25005/2074-0581-2019-21-1-48-54
TREATMENT OF CHRONIC HEART FAILURE IN MIDDLE-AGED MEN WITH DEPRESSION

Kh.S. Sultonov1, Kh.Yo. Sharipova1, G.M. Negmatova2, A.A. Sherbadalov1, F.N. Abdulloev1,3, O.S. Nurulloev1,3

1Department of Propaedeutics of Internal Medicine, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan
2Department of Internal Diseases № 1, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan
3Departments of Neurology and Cardiorheumatology, City Medical Center № 2 named after Academician K.T. Tajiev, Dushanbe, Republic of Tajikistan

Objective: Comparative assessment of the efficiency of standard and combined antidepressant therapy of chronic heart failure (CHF), flowing depression in middle-aged men with mild and moderate arterial hypertension (AH).

Methods: Evaluation of the effectiveness of CHF treatment in patients with absence (Group I) and the presence of depressive disorders (Group II) and combined with antidepressants (paroxetine) of standard therapy for CHF occurring with depression (Group III) was spent. Clinical indices and structural parameters of the myocardium and vessels are studied in the dynamics

Results: In patients with depression not receiving antidepressants, the lack of depression is accompanied by low adherence to treatment and the meaningful by high BP. Despite the high efficacy of standard CHF treatment, the combination with an antidepressant (the importance of improving the structural parameters of the myocardium, reduction of depression and increased adherence to treatment), adherence to treatment is significantly lower than in patients with initial absence of depression

Conclusion: In the absence of depression, standard CHF therapy in middle-aged men with hypertension significantly improves the hemodynamic parameters and the reduced severity of heart failure. Against the background of depression, the effectiveness of CHF treatment (without an antidepressant) is lower: the level of depression, the left ventricular myocardial mass index, and intima-media thickness are much higher, treatment adherence and the ratio of maximum speeds of early and late filling (E/A) are lower than in comparison groups. Combined with paroxetine, standard CHF therapy in middle-aged men with depression, mild depression, and CHF, increases adherence to treatment, improves the structural parameters of the heart. However, adherence to the treatment is meaningful low than in patients who initially lacked depression, which dictates the need to develop effective measures to prevent depressions in patients with the risk of developing CHF.

Keywords: Male sex, middle age, chronic heart failure, hypertension, depression, antidepressant therapy.

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Authors' information:

Sultonov Khabibullo Suvonovich
Assistant, Department of Propaedeutics of Internal Medicine, Avicenna Tajik State Medical University

Sharipova Khursand Yodgorovna
Doctor of Medical Sciences, Full Professor, Professor of the Department of Propedeutics of Internal Diseases, Avicenna Tajik State Medical University

Negmatova Gulnora Mansurovna
Assistant of the Department of Internal Diseases № 1, Avicenna Tajik State Medical University

Sherbadalov Akhmad Akhadovich
Postgraduate Student, Department of Propedeutics of Internal Diseases, Avicenna Tajik State Medical University

Abdulloev Firdavs Nazirovich
Head of the Department of Neurology of the City Medical Center № 2 named after Academician K.T. Tajiev; Competitor of the Department of Propedeutics of Internal Diseases, Avicenna Tajik State Medical University

Nurulloev Oraz Sadulloevich
Doctor at the Cardiorheumatology Department, City Medical Center № 2 named after Academician K.T. Tajiev; Competitor of the Department of Propedeutics of Internal Diseases, Avicenna Tajik State Medical University

Information about support in the form of grants, equipment, medications

The authors did not receive financial support from manufacturers of medicines and medical equipment.

Conflicts of interest: No conflict

Address for correspondence:

Sharipova Khursand Yodgorovna
Doctor of Medical Sciences, Full Professor, Professor of the Department of Propedeutics of Internal Diseases, Avicenna Tajik State Medical University

734003, Republic of Tajikistan, Dushanbe, Rudaki Ave., 139

Tel.: +992 (935) 811297

E-mail: sharipovakh@mail.ru

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