REVIEW ARTICLE
Intensive Care
doi: 10.25005/2074-0581-2025-27-2-416-427
ENDOTHELIAL GLYCOCALYX DEGRADATION IN CEREBRAL EDEMA: PROMISING OPPORTUNITIES FOR INTENSIVE CARE

V.V. MASSOROV1, YU.V. BYKOV1, V.A. BATURIN1, A.P. VOROBYOVA2

1Stavropol State Medical University, Stavropol, Russian Federation
2City Children's Clinical Hospital named after G.K. Filippsky, Stavropol, Russian Federation

A literature review was conducted on the role of the endothelial glycocalyx (eGC) in the pathogenesis of cerebral edema (CE) and the management methods within the context of intensive care. The search for relevant information was carried out using the PubMed, ScienceDirect, and eLibrary databases, employing the following keywords: "cerebral edema", "glycocalyx", "methods of drug correction", "pathogenesis", and "intensive care". The inclusion criteria for thisreview were studiesthat explored markers of eGC degradation in CE and investigationsinto the effects of various methods

and drugs on eGC integrity. Articles older than ten years were excluded from the review.

CE is a significant and potentially life-threatening complication associated with various neurological diseases and injuries. Despite advancesin intensive care, mortality rates for this condition remain high, and treatment options are often limited. One of the primary pathological mechanisms underlying CE is the disruption of the blood-brain barrier, resulting in increased vascular permeability.

Emerging evidence suggests that the eGC, a unique glycoprotein layer on the endothelial surface, plays a crucial role in maintaining the barrier properties of the vascular wall. Damage to the eGC in various pathological conditions contributes to the development of vasogenic edema, triggering inflammation and coagulation. Investigating the molecular mechanisms underlying eGC damage and developing strategies for its protection and restoration are crucial for enhancing outcomes in cases of CE. This area of research presents new opportunities for intensive care, complementing existing treatment approaches. Therefore, studying the role of the eGC in the pathogenesis of cerebral edema and exploring methods for its management are both relevant and clinically significant endeavors.

Keywords: Cerebral edema, glycocalyx, pathophysiology, intensive care.

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Authors' information:

Massorov Vladislav Viktorovich,
Resident of the Department of Anesthesiology and Resuscitation with a Course of Additional Professional Education, Stavropol State Medical University
ORCID ID: 0009-0008-4009-1783
E-mail: vladislav.massorov@yandex.ru

Bykov Yuriy Vitalyevich,
Candidate of Medical Sciences, Associate Professor of the Department of Anesthesiology and Resuscitation with a Course of Additional Professional Education, Stavropol State Medical University
ORCID ID: 0000-0003-4705-3823
E-mail: yubykov@gmail.com

Baturin Vladimir Aleksandrovich,
Doctor of Medical Sciences, Full Professor, Head of the Department of Clinical Pharmacology, with a Course of Additional Professional Education, Stavropol State Medical University
ORCID ID: 0000-0002-6892-3552
E-mail: prof.baturin@gmail.com

Vorobyova Anna Pavlovna,
Anesthesiologist-Reanimatologist of Reanimation and Intensive Care Wards, City Children's Clinical Hospital named after G.K. Filippsky
ORCID ID: 0000-0002-0082-1971
E-mail: a.v.955@yandex.ru

Information about support in the form of grants, equipment, medications

The authors did not receive financial support from manufacturers of medicines and medical equipment

Conflicts of interest: No conflict

Address for correspondence:

Massorov Vladislav Viktorovich
Resident of the Department of Anesthesiology, Reanimatology with a Course of Additional Professional Education, Stavropol State Medical University

355031, Russian Federation, Stavropol, Mira str., 310

Теl.: +7 (962) 4430492

E-mail: vladislav.massorov@yandex.ru


This work is licensed under a Creative Commons Attribution 4.0 International License.

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