REVIEW ARTICLE
Intensive Care
doi: 10.25005/2074-0581-2024-26-4-630-639
SALICYLATE TOXICITY INTENSIVE CARE MANAGEMENT IN CHILDREN

YU.V. BYKOV1,2, A.N. OBEDIN1,3, V.V. FISCHER1,4, E.V. VOLKOV1,5, O.V. ZINCHENKO1, A.A. MURAVYOVA1, I.V. YATSUK1,6

1Department of Anesthesiology and Resuscitation with a Course of Additional Professional Education, Stavropol State Medical University, Stavropol, Russian Federation
2Children's City Clinical Hospital named after G.K. Filippsky, Stavropol, Russian Federation
3Stavropol Regional Clinical Perinatal Center No. 1, Stavropol, Russian Federation
4Shpakovskaya District Hospital, Mikhaylovsk, Russian Federation
5Stavropol Regional Clinical Hospital, Stavropol, Russian Federation
6Stavropol City Clinical Emergency Hospital, Stavropol, Russian Federation

A review of the literature on intensive care (IC) management of acute salicylate (SC) toxicity in children and adolescents was conducted. The information was gathered from the PubMed, Science Direct, and eLibrary databases using the keywords: "salicylates", "children", "adolescents", "acute poisoning", "overdose", and "intensive care." The review included sources published over the last 10 years (2014-2024). The criteria for including studies in the review were data regarding the pathogenesis, clinical manifestations, and specific features of IC for SC poisoning in children and adolescents. Works that focused exclusively on adult patients were excluded from the review. Although the drugs are known to be contraindicated in children, acute SC poisoning continues to be common in pediatric practice. The clinical manifestations are nonspecific and may include central nervous, gastrointestinal, and respiratory disturbances. Measuring plasma SC concentration is a crucial diagnostic test for assessing the severity of poisoning. The effectiveness of gastric lavage has not been proven, and adsorbents are only justified within the first two hours after exposure. Effective IC methods for SC poisoning include infusion therapy, urinary alkalinization using sodium bicarbonate, and extracorporeal treatment. With modern and adequate emergency care, the prognosis for recovery is considered favorable.

Keywords: Salicylates, acetylsalicylic acid, children and adolescents, poisoning, intensive care.

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Authors' information:

Bykov Yuriy Vitalyevich,
Candidate of Medical Sciences, Associate Professor of the Department of Anesthesiology and Resuscitation with a Course of Additional Professional Education, Stavropol State Medical University; Anesthesiologist-Reanimatologist, Children's City Hospital named after G.K. Filippsky
ORCID ID: 0000-0003-4705-3823
E-mail: yubykov@gmail.com

Obedin Aleksandr Nikolaevich,
Doctor of Medical Sciences, Associate Professor, Head of the of Department of Anesthesiology and Resuscitation with a Course of Additional Professional Education, Stavropol State Medical University; Deputy Chief Physician for Pediatric Care, Stavropol Regional Clinical Perinatal Center No. 1
ORCID ID: 0000-0002-9990-7272
Е-mail: volander@mail.ru

Fischer Vasiliy Vladimirovich,
Candidate of Medical Sciences, Associate Professor of the Department of Anesthesiology and Resuscitation with a Course of Additional Professional Education, Stavropol State Medical University; Deputy Chief Medical Officer, Shpakovskaya District Hospital
ORCID ID: 0000-0002-9841-6930
Е-mail: vvfisher26@gmail.com

Volkov Evgeniy Vladimirovich,
Candidate of Medical Sciences, Associate Professor of the Department of Anesthesiology and Resuscitation with a Course of Additional Professional Education, Stavropol State Medical University; Head of the Department of Anesthesiology and Intensive Care No. 1, Stavropol Regional Clinical Hospital
ORCID ID: 0000-0002-9841-6930
Е-mail: volkov26@mail.ru

Zinchenko Oleg Vasilievich,
Candidate of Medical Sciences, Associate Professor of the Department of Anesthesiology and Resuscitation with a Course of Additional Professional Education, Stavropol State Medical University
ORCID ID: 0000-0003-4729-5101
Е-mail: regionar2008@yandex.ru

Muravyova Alla Anatolyevna,
Candidate of Medical Sciences, Associate Professor of the Department of Anesthesiology and Resuscitation with a Course of Additional Professional Education, Stavropol State Medical University
ORCID ID: 0000-0002-4460-870X
Е-mail: muravyeva81@mail.ru

Yatsuk Ivan Viktorovich,
Candidate of Medical Sciences, Associate Professor of the Department of Anesthesiology and Resuscitation with a Course of Additional Professional Education, Stavropol State Medical University; Head of the Department of Anesthesiology and Intensive Care No. 1, Stavropol City Clinical Emergency Hospital
ORCID ID: 0000-0001-5482-8581
Е-mail: yatsukiv@gmail.com

Information about support in the form of grants, equipment, medications

The authors did not receive financial support from manufacturers of medicines and medical equipment

Conflicts of interest: No conflict

Address for correspondence:

Bykov Yuriy Vitalyevich
Candidate of Medical Sciences, Associate Professor of the Department of Anesthesiology and Resuscitation with a Course of Additional Professional Education, Stavropol State Medical University; Anesthesiologist-Reanimatologist, Children's City Hospital named after G.K. Filippsky

355031, Russian Federation, Stavropol, Mira str., 310

Теl.: + 7 (962) 4430492

E-mail: yubykov@gmail.com


This work is licensed under a Creative Commons Attribution 4.0 International License.

Materials on the topic:
  1. ACUTE CEREBROVASCULAR ACCIDENT IN CHILDREN: CLINICAL PRESENTATION AND INTENSIVE CARE MANAGEMENT

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