Infectious Diseases
doi: 10.25005/2074-0581-2019-21-1-43-47
CONDITION OF LIPID PEROXIDATION AND ANTIOXIDANT SYSTEM IN CHILDREN WITH SCARLET FEVER

N.M. Khodzhaeva1, A.M. Saburova2, Z.R. Boboeva1

1Department of Pediatric Infectious Diseases, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan
2Department of Biochemistry, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan

Objective: To study the state of lipid peroxidation (LPO) and the antioxidant system in children with scarlet fever

Methods: The main group consisted of 15 patients with scarlet fever, aged from 7 months to 14 years old, in the inpatient treatment of children’s infectious wards of the Dushanbe City Medical Center for 2017-2018. The patients were separated by the severity of the disease: the medium heavy form – 6 (40%) and the severe form – 9 (60%). The control group consisted of 15 healthy children of the same age. The levels of malondialdehyde (MDA), superoxide dismutase (SOD), ascorbic acid (AA) in serum were determined.

Results: The obtained data testify to deep violations of the system of LPO, what is confirmed by a reliable increase in its metabolites, in particular, MDA in the blood serum of sick children with scarlet fever. Thus, in the acute period of the disease, a significant increase in the level of MDA was observed with the medium heavy form (2.51±0.64 μmol/l) and the severe form (3.41±0.36 μmol/l) compared with the control group (1.21±0.05 µmol/l). Compared with the control group (17.62±1.13 c.u./l), the SOD level in the serum was reduced in the acute period with medium and severe forms of the disease 1.6 and 2 times, respectively, and the level of ascorbic acid compared to with the control group (79.42±4.51 mmol/l) was reduced with medium heavy and severe forms of the disease, respectively, to 41.32±5.03 mmol/l (p1 <0.01) and 37.83±3.54 mmol/l (p1 <0.001).

Conclusion: So scarlet fever in children, depends on the period and severity of the disease, develops elevated peroxidation, and adequately to the level of LPO, reduced activity of antioxidant enzymes that require the conduct corrective therapy

Keywords: Scarlet fever, lipid peroxidation, antioxidant system, children.

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Authors' information:

Khodzhaeva Nigina Murodovna
Doctor of Medical Sciences, Associate Professor, Professor of the Department of Pediatric Infectious Diseases, Avicenna Tajik State Medical University

Saburova Anna Mukhammadievna
Doctor of Biological Sciences, Full Professor, Professor of the Department of Biochemistry, Avicenna Tajik State Medical University

Boboeva Zukhro Raufovna
Postgraduate Student, Department of Pediatric Infectious Diseases, Avicenna Tajik State Medical University

Information about support in the form of grants, equipment, medications

The authors did not receive financial support from manufacturers of medicines and medical equipment.

Conflicts of interest: No conflict

Address for correspondence:

Khodzhaeva Nigina Murodovna
Doctor of Medical Sciences, Associate Professor, Professor of the Department of Pediatric Infectious Diseases, Avicenna Tajik State Medical University

734003, Republic of Tajikistan, Dushanbe, Rudaki Ave., 139

Tel.: +992 (919) 834422

E-mail: nigina51@rambler.ru

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