CASE REPORT
Endocrinology
doi: 10.25005/2074-0581-2026-28-3-898-909
CLINICAL CASE OF DIABETES MELLITUS IN A CHILD 14 YEARS AFTER KIDNEY TRANSPLANTATION

N.A. BELYKH, M.M. RYBAKOVA, I.V. PIZNYUR, D.V. EZHKOV

I.P. Pavlov Ryazan State Medical University, Ryazan, Russian Federation

Post-transplant diabetes mellitus (PTDM) is a serious metabolic complication that develops in recipients after kidney transplantation. Its pathogenesis i multifactorial, combining immunosuppressant-induced insulin resistance with impaired insulin secretion by pancreatic beta cells. The development of PTDM is associated with a significant reduction in patient and graft survival and an increased risk of cardiovascular disease and infectious complications, which accounts for the close attention paid to this problem in transplantology. The incidence of PTDM varies widely, from 5% to 40%, and depends on several factors. These include recipient baseline characteristics (age, overweight, heredity), the immunosuppressive regimen used (particularly high doses of glucocorticoids and tacrolimus), and the duration of follow-up. The peak incidence of diagnosis occurs during the first year after surgery, when immunosuppressive therapy is most intensive. The article provides a detailed analysis of current data on PTDM prevalence, clinical features, and treatment approaches. Particular emphasis is placed on the challenges of diabetes management in transplant recipients, which require maintaining a delicate balance between antidiabetic and immunosuppressive therapy. The authors support the theoretical discussion with their own clinical observation of PTDM in a 14-year-old adolescent.

Keywords: Kidney transplantation, post-transplant diabetes mellitus, chronic kidney disease, postoperative treatment, children, clinical case.

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Authors' information:

Belykh Natalya Anatolyevna,
Doctor of Medical Sciences, Associate Professor, Head of the Department of Faculty and Polyclinic Pediatrics, I.P. Pavlov Ryazan State Medical University
Researcher ID: L-2177-2018
ORCID ID: 0000-0002-5533-0205
SPIN: 2199-6358
E-mail: nbelyh68@mail.ru

Rybakova Marina Mikhaylovna,
6th year Student, Faculty of Pediatrics, I.P. Pavlov Ryazan State Medical University
ORCID ID: 0009-0008-6741-4597
E-mail: marishka20452@mail.ru

Piznyur Inna Vladimirovna,
Assistant Professor, Department of Faculty and Polyclinic Pediatrics, I.P. Pavlov Ryazan State Medical University
Researcher ID: AAO-8423-2020
ORCID ID: 0000-0002-9267-439X
SPIN: 6676-5560
E-mail: innaabramova@yandex.ru

Ezhkov Danila Vladimirovich,
6th year Student, Faculty of Pediatrics, I.P. Pavlov Ryazan State Medical University
ORCID ID: 0009-0005-3031-4638
E-mail: ezhanone@yandex.ru

Information about support in the form of grants, equipment, medications

The authors did not receive financial support from manufacturers of medicines and medical equipment

Conflicts of interest: No conflict

Address for correspondence:

Piznyur Inna Vladimirovna
Assistant Professor, Department of Faculty and Polyclinic Pediatrics, I.P. Pavlov Ryazan State Medical University

390026, Russian Federation, Ryazan, Vysokovoltnaya str., 9

Tel.: +7 (920) 6356099

E-mail: innaabramova@yandex.ru


This work is licensed under a Creative Commons Attribution 4.0 International License.

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