Plastic Surgery
doi: 10.25005/2074-0581-2023-25-2-182-191
OXIDATIVE STRESS AND ANTIOXIDANT SYSTEM IN SEVERE UPPER LIMB INJURIES

G.D. Karim-Zade1, M.Kh.Malikov1, A.M. Saburova2, Kh.R. Nasyrdzhonova2

1Department of Surgical Diseases № 2 named after Academician N.U. Usmanov, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan
2Department of Biochemistry, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan

Objective: To evaluate lipid peroxidation (LPO) and antioxidant defense (AOD) system in severe upper limb injury (SULI) with skin defects covered with autografts

Methods: LPO and AOD system were evaluated in 32 patients after urgent surgical intervention for SULI. The patients were divided into two groups: Group I (main) included 16 patients who underwent reconstructive surgery and antioxidant therapy, and Group II included 16 operated patients who did not receive antioxidant treatment. There were 22 men and 10 women enrolled in the study; the age of the patients varied between 19-51 years, and the average age was 29.2 years. Patients of both groups underwent reconstructive surgery with soft tissue traumatic defects covered with autografts. In both groups, malondialdehyde (MDA) and superoxide dismutase (SOD) were tested in the blood serum before surgery and on the 7th day after surgery. In the main group, patients received a course of antioxidant treatment immediately in the postoperative period for 7 days, while the control group patients did not receive this therapy.

Results: The MDA values before surgery in Groups I and II were similar comprising 3.23±0.41 and 3.35±0.37 µmol/l, respectively. After surgery, there was a considerable decrease in the level of MDA in both groups (p<0.001), however, in Group I this decrease was more significant compared to Group II (1.86±0.32 µmol/l vs. 2.78±0 .43 µmol/l, p<0.001). Initially, the level of SOD in both clinical groups had no statistical differences (p>0.05), amounting to 10.6±2.4 u/ml and 10.2±1.8 u/ml, respectively. The level of SOD on the 7th day after the operation tended to increase in both groups, however, its more significant increase was noted in the main group compared with the control group (15.8±1.3 u/ml and 12.2±1.9 u/ml, respectively, p<0.001).

Conclusion: SULI with skin defects is accompanied by oxidative stress and antioxidants depletion. The use of antioxidant therapy in the postoperative period largely eliminates the disbalance in the LPO-AOD system and improves the results of reconstructive surgeries in SULI.

Keywords: LPO, AOD, MDA, SOD, upper limb injury, autotransplantation, antioxidant therapy.

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Authors' information:

Karim-Zade Gulandom Dzhangovarovna,
Candidate of Medical Sciences, Associate Professor of the Department of Surgical Diseases № 2 named after Academician N.U. Usmanov, Avicenna Tajik State Medical University
Researcher ID: ABD-4810-2021
Scopus ID: 55908934800
SPIN: 4462-0734
Author ID: 1182202
ORCID ID: 0000-0003-0845-3197
E-mail: gulandom71@mail.ru

Malikov Mirzobadal Khalifaevich,
Doctor of Medical Sciences, Associate Professor, Head of the Department of Surgical Diseases № 2 named after Academician N.U. Usmanov, Avicenna Tajik State Medical University
Researcher ID: ABG-2983-2021
Scopus ID: 21934165100
ORCID ID: 0000-0002-7816-5521
Author ID: 375497
E-mail: mmirzobadal@mail.ru

Saburova Anna Mukhammadievna,
Doctor of Biological Sciences, Full Professor, Professor of the Department of Biochemistry, Avicenna Tajik State Medical University
ORCID ID: 0000-0002-5719-1114
SPIN: 9132-9748
Author ID: 425954
E-mail: 20@tajmedun.tj

Nasyrdzhonova Kyursand Rakhimovna,
Candidate of Biological Sciences Senior Lecturer of the Department of Biochemistry, Avicenna Tajik State Medical University
ORCID ID: 0000-0002-5914-8806
SPIN: 9872-3549
Author ID: 240263
E-mail: n_hursand@mail.ru

Information about support in the form of grants, equipment, medications

The authors did not receive financial support from companies manufacturing medications and medical equipment

Conflicts of interest: No conflict

Address for correspondence:

Karim-Zade Gulandom Dzhangovarovna
Candidate of Medical Sciences, Associate Professor of the Department of Surgical Diseases № 2 named after Academician N.U. Usmanov, Avicenna Tajik State Medical University

734003, Republic of Tajikistan, Dushanbe, Rudaki Ave., 139

Tel.: +992 (918) 808766

E-mail: gulandom71@mail.ru

Materials on the topic:
  1. REPAIR OF SEVERE POST-BURN CICATRICIAL CONTRACTURES AND DEFORMATIONS OF THE LOWER LIMB
  2. ANALYSIS OF COMPLICATIONS AFTER AUTOGRAFT TRANSPLANTATION IN SEVERE UPPER LIMB INJURY
  3. A MODEL FOR ASSESSING THE RISK OF A DELAYED WOUND HEALING IN OBESE PATIENTS
  4. MAMMOPLASTY: FROM RECONSTRUCTIVE TO AESTHETIC SURGERY
  5. THE EFFECT OF THE MENSTRUAL CYCLE PHASE ON THE OUTCOME OF AUGMENTATION MAMMOPLASTY
  6. CORRECTION OF SOFT-TISSUE DEFECTS AND CONSEQUENCES OF NEUROVASCULAR BUNDLES DAMAGE OF THE UPPER EXTREMITIES
  7. SURGICAL TREATMENT OF POST-BURN CICATRICIAL DEFORMITIES OF WOMAN’S BREAST

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