Oncology

doi: 10.25005/2074-0581-2022-24-3-324-330
FIRST RESULTS OF TREATMENT OF CERVICAL INTRAEPITHELIAL NEOPLASIA IN THE REPUBLIC OF TAJIKISTAN

N.A. Mukhsinzoda1, S.G. Umarova2

1Republican Cancer Research Center, Dushanbe, Republic of Tajikistan
2Department of Oncology and Radiation Diagnostics, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan

Objective: To assess the clinical results of cervical intraepithelial neoplasia (CIN) treatment following the outcomes of the first pilot implementation of visual screening in the Republic of Tajikistan.

Methods: The study was conducted from 2016 to 2020. The piloting included the population of two large districts of Kushoniyon and B. Gafurov, with a total number of 608,700 people, which is 6.74% of the country's total population. The target group of this screening included healthy women aged 30-49 years, numbering 72574 people. As a result of communication campaigns with the target group of both districts, 69391 women participated in visual screening; the overall screening coverage was 94.2%. Of the 2958 women referred for diagnosis, in 164 cases (0.24%) CIN was identified and morphologically confirmed.

Results: Tajikistan, along with piloting imaging screening, has adopted a "detection-diagnosis-treatment" strategy, which involves treatment after histological confirmation of CIN. Additionally, electrosurgical loop excision/conization was adopted as the primary method, regardless of the degree of CIN involvement. Patients with CIN in 136 (82.9%) cases underwent electrosurgical loop excision, in 21 cases – conization (12.8%), and in 7 (4.3%) cases, at the insistence of the women themselves – hysterectomy. In the long-term follow-up period from 6 months to 2 years, in 159 (96.9%) cases, a favorable course of CIN was noted after the above procedures, and in 5 (3.1%) cases, relapse occurred. Patients with relapses received re-surgical treatment using electrosurgical excision/conization with a satisfactory outcome.

Conclusion: The "detection-diagnosis-treatment" strategy adopted by Tajikistan has shown its high efficiency in detecting precancerous pathology and the success of CIN treatment by electrosurgical excision/conization, which contributes to the healing of the population from precancerous pathology.

Keywords: Cervical intraepithelial neoplasia, visual screening, VIA/VILI visual method, colposcopic examination, electrosurgical loop excision/conizatio.

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Authors informations:

Mukhsinzoda Nilufar Abdukakhkhorovna
Oncogynecologist, Department of Reproductology, Republican Cancer Research Center
ORCID ID: 0000-0002-8285-9091
SPIN: 6837-6437
Author ID: 1135265
E-mail: Nilufar.Abdugaffarova@mail.ru

Umarova Saida Gayratovna
Doctor of Medical Sciences, Professor of the Department of Oncology and Radiation Diagnostics, Avicenna Tajik State Medical University
ORCID ID: 0000-0002-5795-7503
SPIN: 4808-1066
Author ID: 1062229
E-mail: saida.umarova@bk.ru

Information about the source of support in the form of grants, equipment, and drugs

The authors did not receive financial support from manufacturers of medicines and medical equipment

Conflict of interest: No conflict

Address for correspondence:

Mukhsinzoda Nilufar Abdukakhkhorovna
Oncogynecologist, Department of Reproductology, Republican Cancer Research Center

734025, Republic of Tajikistan, Dushanbe, Abuali Sino str., 58

Tel.: +992 (777) 002135

E-mail: Nilufar.Abdugaffarova@mail.ru

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