Pediatrics
doi: 10.25005/2074-0581-2020-22-3-409-418
HUMAN HERPES VIRUS TYPE 6 INFECTION IN CHILDREN AFTER ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION IN THE REPUBLIC OF BELARUS

E.P. Kishkurno1`, T.V. Amvrosieva2, Yu.E. Mareyko3, E.V. Divakova4

1Belarusian Medical Academy of Postgraduate Education, Minsk, Republic of Belarus
2Republican Research and Practical Center for Epidemiology and Microbiology, Minsk, Republic of Belarus
3Republican Scientific Research Center for Pediatric Oncology, Hematology and Immunology, Minsk, Republic of Belarus
4Belarusian State Medical University, Minsk, Republic of Belarus

Objective: To evaluate the frequency of reactivation of HHV-6 infection in patients after allogeneic hematopoietic stem cell transplantation (allo-HSCT); determine viral load in serum/plasma and associated clinical manifestations; to determine the criteria for initiating anti-viral prophylaxis and etiotropic therapy in patients with this infection in the Republic of Belarus.

Methods: Monitoring of polymerase chain reaction (PCR) of blood serum in 42 patients after allo-HSCT.

Results: In 31% of patients, HHV-6 DNA was detected in serum/plasma on 14-28 days after allo-HSCT. The concentration of HHV-6 DNA in blood serum was up to 2.3-6.5×103 copies/ml, in 3 patients (18.8%) with the concentration of DNA≥2.3×103 copies/ml, developed clinical manifestations in the form of hepatitis. Regular monitoring of HHV-6 infection revealed reactivation of the infection and, with a viral load of≥100 copies/ml, initiate timely preventive treatment with ganciclovir.

Conclusion: HHV-6 DNA is detected in one-third of patients after allo-HSCT and in the form of hepatitis. Timely prevention and therapy with ganciclovir reduce the risk of severe complications and fatal outcomes.

Keywords: Children, HHV-6, hematology, stem cells transplantation, hepatitis.

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Authors' information:

Kishkurno Elena Petrovna
Candidate of Medical Sciences, Associate Professor of the Department of Infectious Diseases and Pediatric Infectious Diseases, Belarusian Medical Academy of Postgraduate Education
Scopus ID: 56725794500
ORCID ID: 0000-0002-7389-0898
SPIN: 7790-8198
Author ID: 1007037
E-mail: e-kishkurno@yandex.ru

Amvrosieva Tamara Vasilievna
Doctor of Medical Sciences, Full Professor, Head of the Laboratory of Infections with Natural Reservoir, Republican Research and Practical Center for Epidemiology and Microbiology
Scopus ID: 6508223531
ORCID ID: 0000-0001-7309-152X
SPIN: 3357-5610
Author ID: 1073282
E-mail: amvrosieva@gmail.com

Mareyko Yuliya Evgenievna
Physician, Department of Transplantation, Republican Research and Practical Center for Pediatric Oncology, Hematology and Immunology
ORCID ID: 0000-0003-4172-9466
E-mail: muc@inbox.ru

Divakova Ekaterina Vyacheslavovna
Assistant of the Department of Pediatric Infectious Diseases, Belarusian State Medical University
Researcher ID: AAP-3192-2020
ORCID ID: 0000-0002-3684-8535
SPIN: 1647-7018
Author ID: 988975
E-mail: katerina.divakova@gmail.com

Information about support in the form of grants, equipment, medications

The authors did not receive financial support from manufacturers of medicines and medical equipment

Conflicts of interest: No conflict

Address for correspondence:

Kishkurno Elena Petrovna
Candidate of Medical Sciences, Associate Professor of the Department of Infectious Diseases and Pediatric Infectious Diseases, Belarusian Medical Academy of Postgraduate Education

220013, Republic of Belarus, Minsk, P. Brovki str., 3, bldg. 3

Tel.: +375 (296) 504344

E-mail: e-kishkurno@yandex.ru

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