Pediatrics
doi: 10.25005/2074-0581-2020-22-3-427-433
FEATURES OF CLINICAL MANIFESTATIONS, CELLULAR AND HUMORAL IMMUNITY OF NEWBORNS WITH INTRAUTERINE MIXED INFECTIONS

M.A. Yusupova, K.I. Ismoilov

Department of Pediatric Diseases № 2, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan

Objective: To study the features of clinical manifestations, cellular and humoral immunity of newborns with intrauterine mixed infections (IUMI).

Methods: A comprehensive survey of 45 infants with IUMI was carried out. Depending on the classification of IUMI they were divided into 3 main groups: group I – 24 patients (53%) with the viral-bacterial association, group II – 12 patients (27%) with the viral-viral association, and group III – 9 patients (20%) with the viral-parasitic association. The control group consisted of 10 newborns born from uninfected, somatically healthy mothers. Diagnosis of IUMI was based on the detection of specific antibodies of the IgA, IgG and IgM classes, as well as phagocytic activity and phagocytic index of leukocytes. In addition, general clinical, biochemical, bacteriological and instrumental research methods have been conducted.

Results: The blood serum IgA and IgM indices in patients of the main group were significantly higher, and the mean IgG values were lower compared to the control group. Analysis of cellular immunity parameters in the main group showed a decrease in the number of mature T-lymphocytes (CD3), B-lymphocytes (CD20), the number of T-helpers and cells that produce IL-2 in the peripheral blood, compared with the control group. In the main group, there was also an increase in the number of apoptosis cells (CD95), cells with high cytotoxic activity (CD25, CD71) and the percentage of natural killer cells (CD16). A decrease in the phagocytic activity and phagocytic index of neutrophils was recorded, which indicates the insufficiency of the nonspecific component of immunity.

Conclusion: In newborns, various changes were found both on the part of specific and nonspecific components of immunity. This indicates the development of secondary immunodeficiency in this category of patients and makes it necessary to add to the main treatment of immune corrective therapy.

Keywords: Congenital infections, mixed intrauterine infections, TORCH syndrome, opportunistic infections, secondary immunodeficiency.

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Authors' information:

Yusupova Mukaramkhon Aslonovna
Candidate of Medical Sciences, Assistant of the Department of Pediatric Diseases № 2, Avicenna Tajik State Medical University
ORCID ID: 0000-0002-2922-5372
SPIN: 1453-6316
Author ID: 1064794
E-mail: Aslankizi@yandex.ru

Ismoilov Komildzon Isroilovich
Doctor of Medical Sciences, Full Professor, Head of the Department of Children’s Diseases № 2, Avicenna Tajik State Medical University
ORCID ID: 0000-0003-2431-1551
SPIN: 6886-8004
Author ID: 847074
E-mail: ismoilov52@inbox.ru

Information about support in the form of grants, equipment, medications

The work was carried out according to the plan of scientific research works of Avicenna Tajik State Medical University (state registration number – 0119TJ00999). The authors did not receive financial support from manufacturers of medicines and medical equipment

Conflicts of interest: No conflict

Address for correspondence:

Yusupova Mukaramkhon Aslonovna
andidate of Medical Sciences, Assistant of the Department of Pediatric Diseases № 2, Avicenna Tajik State Medical University

734003, Republic of Tajikistan, Dushanbe, Rudaki Ave., 139

Tel.: +992 (935) 033223

E-mail: Aslankizi@yandex.ru

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