FOR THE MEDICAL PRACTITIONER
Urology
doi: 10.25005/2074-0581-2026-28-3-851-860
URINARY SYSTEM STATUS IN ATHLETES ACCORDING TO THEIR GENETIC PROFILE

D.KH. RYBALKINА, L.K. IBRAYEVA, I.V. BACHEVA, D.A. ZHUMAGALIYEVA, G.B. KHAMRAYEVA, P.V. OVTSYNOV

Department of Internal Medicine, Karaganda Medical University, Karaganda, Republic of Kazakhstan

Objective: To analyze urinary system function in athletes from the Karaganda Region of Kazakhstan, considering genetic polymorphisms

Methods: A total of 103 male athletes aged 18-45 years were examined, including handball, football, hockey, and combat sports athletes. The examination included genetic analysis of polymorphisms in the ACE rs4341, ADRB2 rs1042713 and rs1042714, AGT rs699, NOS3 rs2070744, and AQP rs1049305 genes; biochemical blood tests; bioimpedance analysis; and heart rate variability assessment.

Results: In 14.6% of athletes, the risk of dehydration during physical exertion was above average (homozygous carriers of the AQP rs1049305 C/C genotype). In 22.3% of the athletes, creatinine levels exceeded the upper limit of the reference range. In 30.1% of the athletes, the glomerular filtration rate (GFR) corresponded to mildly decreased kidney function. The proportion of individuals with GFR values characteristic of mildly decreased kidney function was higher among combat sports athletes. The highest hydration index values, indicative of moderate edema, were detected in the legs. The proportion of homozygous carriers of polymorphisms in the ACE, ADRB2, AGT, and NOS3 genes associated with increased blood pressure risk ranged from 7.7% to 36.9%.

Conclusion: Renal dysfunction was identified in several athletes, along with genotype-associated risks, suggesting the need to investigate possible causes and implement preventive measures.

Keywords: Urinary system, creatinine, urea, glomerular filtration rate, bioimpedance analysis, sports genomics.

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Authors' information:

Rybalkina Dina Khabibullayevna,
Candidate of Medical Sciences, Associate Professor, Professor of the Department of Internal Medicine, Karaganda Medical University
Researcher ID: AFF-7942-2022
Scopus ID: 54890642500
ORCID ID: 0000-0002-2041-1259
SPIN: 3642-8076
Author ID: 653092
E-mail: ystas666@list.ru

Ibrayeva Lyazat Katayevna,
Doctor of Medical Sciences, Full Professor, Professor of the Department of Internal Diseases, Karaganda Medical University
Researcher ID: ABZ-8951-2022
Scopus ID: 56712888900
ORCID ID: 0000-0002-9917-0258
SPIN: 2364-4308
Author ID: 718859
E-mail: libraeva@qmu.kz

Bacheva Irina Viktorovna,
PhD, Associate Professor of the Department of Internal Medicine, Karaganda Medical University
Researcher ID: AAR-4890-2020
Scopus ID: 56612421200
ORCID ID: 0000-0002-5576-8637
SPIN: 4688-8543
Author ID: 1035317
E-mail: bacheva@qmu.kz

Zhumagaliyeva Diana Askarovna,
Doctoral Student of the Department of Internal Medicine, Karaganda Medical University
ORCID ID: 0009-0003-8028-6482
E-mail: zhumagalievaD@qmu.kz

Khamrayeva Gulshan Babamuratkyzy,
Resident Nephrologist, 2 years of study at the Department of Internal Diseases, Karaganda Medical University
ORCID ID: 0009-0009-9760-3185
E-mail: hamraevaG@qmu.kz

Ovtsynov Pavel Vladislavovich,
Resident of the Department of Internal Medicine, Karaganda Medical University
Scopus ID: 59540987400
ORCID ID: 0009-0006-0450-3053
E-mail: ovcynov@qmu.kz

Information about support in the form of grants, equipment, medications

This work was supported by the Ministry of Science and Higher Education of the Republic of Kazakhstan under Grant AP23490397, “Analysis of the Molecular Genetic Mechanisms of Endurance in Athletes Demonstrating Effective Sports Performance” (2024-2026). The authors did not receive financial support from manufacturers of medicines and medical equipment

Conflicts of interest: No conflict

Address for correspondence:

Zhumagaliyeva Diana Askarovna
Doctoral Student of the Department of Internal Medicine, Karaganda Medical University

100008, Republic of Kazakhstan, Karaganda, Gogol str., 40

Tel.: +7 (701) 1000910

E-mail: zhumagalievaD@qmu.kz


This work is licensed under a Creative Commons Attribution 4.0 International License.

Materials on the topic:
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  2. A SURGICAL DECISION-MAKING FRAMEWORK FOR OPTIMAL APPROACHES TO NEPHRECTOMY
  3. PREDICTIVE ABILITY OF IMMUNOGENETIC STUDIES FOR INCIDENCE OF UROLITHIASIS IN CHILDREN
  4. OPTIMIZATION OF THE SURGICAL TECHNIQUE OF EXTRAVESICAL URETERAL REIMPLANTATION

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