Review articles

doi: 10.25005/2074-0581-2022-24-3-385-393
COVID-19 AND WOMEN'S REPRODUCTIVE HEALTH

G.S. Mirzozoda, M.F. Dodkhoeva, R.A. Abdullaeva

Department of Obstetrics and Gynecology № 1, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan

The authors present a literature review examining the impact of COVID-19 on women's reproductive health. It is noted that menstrual dysfunction creates intense stress in a woman's body. The stress caused by the pandemic could potentially put women at higher risk of endocrine disruption. Furthermore, coronavirus infection adversely affects the course of pregnancy and labour, increasing the number of premature births and the frequency of delivery by caesarean section. The status of the fetus and changes in the uteroplacental complex in SARS-CoV-2, during pregnancy and subsequent pregnancies, have not been sufficiently studied. Researchers agree that timely diagnosis of the sequelae of COVID-19 in women will allow the development of new preventive and therapeutic strategies to restore optimal reproductive health.

Keywords: COVID-19, menstrual cycle, reproductive health, pregnancy, stress.

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References
  1. Khirmanov VN. COVID-19 kak sistemnoe zabolevanie [COVID-19 as a systemic disease]. Klinicheskaya farmakologiya i terapiya. 2021;30(1):5-15.
  2. Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y, Feng Z. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. NEJM. 2020;382(13):1199-207.
  3. Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, et al. Clinical characteristics of coronavirus disease 2019 in China. NEJM. 2020;382(18):1708-20. Available from: https://doi.org/10.1056/NEJMoa2002032
  4. Henderson LA, Canna SW, Schulert GS, Volpi S, Lee PY, Kernan KF, et al. On the alert for cytokine storm: Immunopathology in COVID-19. Arthritis Rheum. 2020;72(7):1059-63. Available from: https://doi.org/10.1002/art.41285
  5. Adambaev ZI, Kilichev IA, Khudoyberganov NYu, Nurzhonov AB, Khodzhanova TR. Nevrologicheskie narusheniya posle COVID-19. Postkovidnyy sindrom ili dolgiy kovid ili postostrye posledstviya COVID-19 [Neurological disorders after COVID-19. Post- COVID syndrome or long COVID or post-acute consequences of COVID-19]. Zhurnal nevrologii i neyrokhirurgicheskikh issledovaniy. 2022;3(2):11-6.
  6. Papicheva MA, Golubeva MYu. Vliyanie chastoty vozniknoveniya ostrykh respiratornykh zabolevaniy na razvitie adneksita [Influence of the frequency of occurrence of acute respiratory diseases on the development of adnexitis]. Sovremennye problemy zdrovookhraneniya i meditsinskoy statistiki. 2022;2.89- 106.
  7. Nillni YI, Wesselink AK, Hatch EE, Mikkelsen EM, Gradus JL, Rothman KJ, et al. Mental health, psychotropic medication use, and menstrual cycle characteristics. Clinical Epidemiology. 2018;10:1073-82.
  8. Jing Y, Run-Qian L, Hao-Ran W, Hao-Ran C, Ya-Bin L, Yang G, et al. Potential influence of COVID-19/ACE2 on the female reproductive system. Mol Hum Reprod. 2020;26(6):367-73.
  9. Lee WY, Mok A, Chung JP. Potential effects of COVID-19 on reproductive systems and fertility; assisted reproductive technology guidelines and considerations: A review. Hong Kong Medical Journal. 2021;27(2):118.
  10. Khudoyarova DR, Ganieva AB, Kholmurodova KhKh, Khodzhieva KF. Vliyanie COVID-19 i vaktsinatsii protiv COVID-19 na menstrualnuyu funktsiyu i na menstrualnyy tsikl zhenshin [Effect of COVID-19 and vaccination against COVID-19 on menstrual function and the menstrual cycle of women]. Scientific Approach to the Modern Education System.2022;1(5):72-6.
  11. Khalimova ZYu, Nasirova KhK, Mekhmanova SU. Otsenka narusheniy reproduktivnogo statusa zhenshin posle perenesennoy koronavirusnoy infektsii (COVID-19) [Assessment of violations of the reproductive status of women after coronavirus infection (COVID-19)]. Ijtimoiy Fanlarda Innovasiya Onlayn Ilmiy Jurnali. 2022;118-23.
  12. Li K, Chen G, Hou H, Liao Q, Chen J, Bai H, et al. Analysis of sex hormones and menstruation in COVID-19 women of child-bearing age. Reprod Biomed. Online. 2021;42(1):260-7.
  13. Khan SM, Shilen A, Helsin KM, Ishimwe P, Allen AM, Jacobs ET, et al. SARSCoV- 2 infection and subsequent changes in the menstrual cycle among participants in the Arizona CoVHORT study. American Journal of Obstetrics & Gynecology. 2022;226(2):270-3.
  14. Parfyonova YaA, Shibelgut NM, Artymuk NV. Vliyanie novoy koronavirusnoy infektsii COVID-19 na reproduktivnoe zdorove zhenshin [Impact of novel coronavirus infection COVID-19 on women's reproductive health]. Mat’ i ditya v Kuzbasse. 2021;3:36-40.
  15. Phelan N, Behan LA, Owens L. The impact of the COVID-19 pandemic on women’s reproductive health. Front Endocrinol. 2021;12:642755. Available from: https://doi.org/10.3389/fendo.2021.642755
  16. Maltseva AN. Vliyanie COVID-19 na menstrualnuyu funktsiyu zhenshin v reproductivnom periode [The impact of COVID-19 on the menstrual function of women in the reproductive period]. RMZH. Mat’ i ditya. 2022;5(2):112-7.
  17. Li R, Yin T, Fang F, Li Q, Chen J, Wang Y, et al. Potential risks of SARS-CoV-2 infection on reproductive health. Reprod Biomed Online. 2020;41(1):89-95.
  18. Abdulkhakov IU. Koronavirusnaya infektsiya COVID-2019 – globalizatsiya protsessa [Coronavirus infection COVID-2019 – globalization of process]. Biologiya i integrativnaya meditsina. 2020;6:163-72.
  19. Lipay TP. Pandemiya COVID-19: depressiya, trevoga, stigma i vliyaniye na psikhicheskoye zdorov'ye [The COVID-19 pandemic: Depression, anxiety, stigma and impact on mental health]. Problemy sotsialnoy gigieny, zdravookhranenia i istorii meditsini. 2020;28(5):922-7. Available from: https://doi. org/10.32687/0869-866X2020-28-5-922-927
  20. Mitkovskaya NP, Karpov IA, Arutyunov GP, Grigorenko EA, Ruzanov DYu, Statkevich TV, i dr. Koronavirusnaya infektsiya COVID-19 (obzor mezhdunarodnykh nauchnykh dannykh) [COVID-19 coronavirus infection (overview of international research data)]. Neotlozhnaya kardiologiya i kardiovaskulyarnye riski. 2020;4(1):784-815.
  21. Podzolkova NM, Danshina VA. Narusheniya menstrual’nogo tsikla v reproduktivnom periode [Menstrual disorders in the reproductive period]. Meditsinskiy sovet. 2014;9:44-9.
  22. Volel BA, Ragimova AA, Burchakov DI, Burchakova MN, Kuznitsova IV. Stress-zavisimye narusheniya menstrual’nogo tsikla [Stress-dependent menstrual disorders]. Consilium Medicum. 2016;18(6):8-13.
  23. Demir O, Sal H, Comba C. Triangle of COVID, anxiety and menstrual cycle. J Obstet Gynaecol. 2021;41(8):1257-61.
  24. Ozimek N, Velez K, Anvari H, Butler L, Goldman KN, Woitowich NC. Impact of Stress on Menstrual Cyclicity During the Coronavirus Disease 2019 Pandemic: A Survey Study. J Womens Health (Larchmt). 2022 Jan;31(1):84-90.
  25. Takmaz T, Gundogmus I, Okten SB, Gunduz A. The impact of COVID‐19‐related mental health issues on menstrual cycle characteristics of female healthcare providers. Journal of Obstetrics and Gynaecology Research. 2021;47(9):3241-9.
  26. Alekseev BE, Belous IM. Seksual’nye disfunktsii u zhenshin s psikhogennymi depressiyami [Sexual dysfunctions in women with psychogenic depression]. Obozrenie psikhiatrii i meditsinskoy psikhologii imeni V.M. Bekhtereva. 2013;1:22-4.
  27. Trishkin AG. Perinatalnye iskhody pri materinskoy smertnosti [Perinatal outcomes in maternal mortality]. Vestnik NGU. Biologiya, klinicheskaya meditsina. 2011;9(4):129-33.
  28. Chen L, li Q, Zheng D, Jiang H, Wei Y, Zou L, et al. Clinical characteristics of pregnant women with COVID-19 in Wuhan, China. NEJM. 2020;38(25):100.
  29. Kasimova ZN, Akmalkhojaeva II, Rustamova RI, Kosimova MD. Koronavirusnaya infektsiya vo vremya beremennosti (na primere Sogdiyskoy oblasti) [Coronavirus infection during pregnancy (on the example of the Sughd region]. Mat` i ditya. 2021;3:34-6.
  30. Abdusamatzoda ZM, Davlatzoda GK, Ishan-Khodzhaeva FR. Rezul’taty otsenki ob”yoma krovopoteri v rodakh u zhenshchin, perenyosshikh novuyu koronavirusnuyu infektsiyu vo vremya beremennosti [The results of assessing the volume of blood loss during childbirth in women who have had a new coronavirus infection during pregnancy]. Mat’ i ditya. 2021;3:9-11.
  31. Abdusamatzoda ZM, Yunusova DZ, Mukhamadieva SM, Pulatova AP, Mirzabekova BT. Reproduktivnye poteri v period COVID-19 [Reproductive losses during COVID-19]. Mat’ i ditya. 2021;3:12-7.
  32. Wang MJ, Schapero M, Iverson R, Yarrington CD. Obstetric hemorrhage risk associated with novel COVID-19 diagnosis from a single-institution cohort in the United States. American Journal of Perinatology. 2020;37(14):1411-6.
  33. Kampf G, Todt D, Pfaender S, Steinmann E. Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents. J Hosp Infect. 2020;104(3):246-51. Available from: https://doi.org/10.1016/j. jhin.2020.01.022
  34. Khodzhamurodova DA, Oshurmamadova RB, Khayridinova SS, Odinaeva ZS, Rakhmatova GR. Rekonvalestsent COVID-19, techenie i oslozhneniya beremennosti v I trimestre [COVID-19 convalescence, course and complications of pregnancy in the first trimester]. Mat’ i ditya. 2021;3:46-50.
  35. Kurbanova MKh, Bolieva GU, Azimova DA, Mamedova ZT. Kliniko-laboratornaya kharakteristika i reproduktivnye poteri v pervom trimestre beremennosti u rekonvalestsentov COVID-19 [Clinical and laboratory characteristics and reproductive losses in the first trimester of pregnancy in COVID-19 convalescents. Mat’ i ditya. 2021;3:36-8.
  36. Di Mascio D, Khalil A, Saccone G, Rizzo G, Buca D, Liberati M, et al. Outcome of coronavirus spectrum infections (SARS, MERS, COVID 19) during pregnancy: A systematic review and meta-analysis. Am J Obstet Gynecol MFM. 2020;2(2):100-7.
  37. Kalandarova MKh, Davlatzoda GK, Gadoeva TKh, Ishan-Khodzhaeva FR, Arabova SU. Chastota kesareva secheniya v statsionare 3-go urovnya v period pandemii COVID-19 [The frequency of cesarean section in a level 3 hospital during the COVID-19 pandemic]. Mat’ i ditya. 2021;3:26-8..

Authors' information:


Mirzozoda Gulchini Subkhon
Applicant of the Department of Obstetrics and Gynecology № 1, Avicenna Tajik State Medical University
ORCID ID: 0000-0002-5085-8297
E-mail: gulchin.mirzozoda@mail.ru

Dodkhoeva Munavvara Fayzulloevna
Academician of the National Academy of Sciences of Tajikistan, Doctor of Medical Sciences, Full Professor, Professor of the Department of Obstetrics and Gynecology № 1, Avicenna Tajik State Medical University
Researcher ID: AAC-4784-2019
ORCID ID: 0000-0001-9373-4318
SPIN: 9749-6174
Author ID: 313026
E-mail: dodkho2008@mail.ru

Abdullaeva Rano Abdugaffarovna
Candidate of Medical Sciences, Associate Professor, Head of the Department of Obstetrics and Gynecology № 1, Avicenna Tajik State Medical University
ORCID ID: 0000-0003-3100-2343
SPIN: 7066-3825
Author ID: 1111132
E-mail: ranoshechka74@mail.ru

Information about support in the form of grants, equipment, medications

The authors did not receive financial support from manufacturers of medicines and medical equipment

Conflicts of interest: No conflict

Address for correspondence:


Dodkhoeva Munavvara Fayzulloevna
Academician of the National Academy of Sciences of Tajikistan, Doctor of Medical Sciences, Full Professor, Professor of the Department of Obstetrics and Gynecology № 1, Avicenna Tajik State Medical University

734003, Republic of Tajikistan, Dushanbe, Rudaki Ave., 139

Tel.: +992 (918) 612606

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