Internal Medicine
doi: 10.25005/2074-0581-2021-23-1-18-24
THE EFFECTIVENESS OF OZONE THERAPY FOR ARTERIAL HYPERTENSION AND CONCOMITANT GASTROPATHY IN MINERS

A.R. Kudasheva1, A.Kh. Khusainova1, N.R. Gazizova2, F.A.Ur mantseva2

1Department of Therapy and Occupational Diseases, Bashkir State Medical University, Ufa, Republic of Bashkortostan, Russian Federation
2Ufa Research Institute of Occupational Medicine and Human Ecology, Ufa, Republic of Bashkortostan, Russian Federation

Objective: To evaluate the effectiveness of ozone therapy in the combination of arterial hypertension (AH) and gastropathy in miners.

Methods: Two groups of male miners with AH and gastropathy were analyzed: group I – 43 miners aged 47.4±1.3 years with work experience of 27.9±1.9 years and group II – 42 miners aged 46.9±1.4 years with work experience of 27.1±1.8 years. Group II received drug treatment only, and group I, in addition, received ozone therapy. An ozone-oxygen mixture was administered intravenously in an amount of 200-400 ml with an ozone concentration in a solution of 1-1.5 mg/l five times every other day. To assess the effectiveness of the ozone therapy, the lipid profile was studied, the level of blood pressure was monitored, and fibrogastroduodenoscopy was performed. Patients were examined before the start of the course of ozone therapy, control examinations were carried out on the 12th day from the moment of treatment.

Results: In both groups, individuals with grade I AH showed a statistically significant (p<0.0001) decrease in both SBP and DBP by the 12th day of hospital stay. Changes in the lipid profile were noted in group I: the concentrations of total cholesterol and triglycerides decreased by 1.3 and 1.4 times, respectively compared to the initial data; the atherogenic index of plasma approached normal values, which was not observed in group II. The condition of the gastroduodenal mucosa in the group I improved: atrophic-sclerotic signs underwent positive changes in 56% of cases; in patients with erosive lesions, mucosal regeneration was noted in all cases. In group II, atrophic processes of the mucosa remained unchanged, while erosive lesions of the mucosa decreased only 1.5-2 times.

Conclusion: This study testifies to the effectiveness of ozone therapy in the complex treatment of arterial hypertension in combination with erosive and atrophic lesions of the gastroduodenal zone.

Keywords: Arterial hypertension, gastroduodenal zone, erosive gastritis, ozone therapy, triglycerides, total cholesterol.

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Authors' information:

Kudasheva Alfiya Ravilevna
Candidate of Medical Sciences, Associate Professor of the Department of Therapy and Occupational Diseases, Bashkir State Medical University
ORCID ID: 0000-0001-6460-9868
SPIN: 8839-4770
Author ID: 723391
E-mail: alfa_9@inbox.ru

Кhusainova Aygul Khamzeevna
Assistant of the Department of Therapy and Occupational Diseases, Bashkir State Medical University
ORCID ID: 0000-0003-4287-8594
SPIN: 3746-9472
Author ID: 952830
E-mail: khusainova0714@mail.ru

Gazizova Nailya Rifovna
Head of the Department of Therapy and Occupational Diseases, Ufa Research Institute of Occupational Medicine and Human Ecology
ORCID ID: 0000-0003-4287-8594
SPIN: 1007-3366
Author ID: 904835
E-mail: nelli.ga012@gmail.com

Urmantseva Ferdaus Anvarovna
Head of the Department of Physiotherapy, Ufa Research Institute of Occupational Medicine and Human Ecology
ORCID ID: 0000-0002-3087-189Х
SPIN: 5414-9311
Author ID: 906666
E-mail: lady.ferdaus@yandex.ru

Information about support in the form of grants, equipment, medications

The work was carried our according to the plan of scientific research works of the Ufa Research Institute of Occupational Medicine and Human Ecology (registration number – АААА-А19-119110500061-9). The authors did not receive financial support from manufacturers of medicines and medical equipment

Conflicts of interest: No conflict

Address for correspondence:

Kudasheva Alfiya Ravilevna
Candidate of Medical Sciences, Associate Professor of the Department of Therapy and Occupational Diseases, Bashkir State Medical University

450000, Russian Federation, Republic of Bashkortostan, Ufa, Lenin Str., 3

Tel.: +7 (965) 9307933

E-mail: alfa_9@inbox.ru

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