Case Reports

doi: 10.25005/2074-0581-2019-21-4-689-693
CHOROIDAL OSTEOMA: CLINICAL AND DIAGNOSTIC FEATURES

A.A. Yarovoy, V.A. Yarovaya, D.S. Astarkhanova, S.S. Kleyankina

S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation

Objective: To present own experience of choroidal osteoma (CO) management.

Methods: The study included 4 patients (4 eyes), who were monitored from 2018 to 2019. The age of the patients ranged from 17 to 45 years (average age – 29 years). According to the indications, an angiogenesis inhibitor was injected intravitreally to one patient. One patient underwent diode laser thermotherapy. Follow-up without treatment was recommended for two patients.

Results: In all cases, CO was presented by a yellowish paramacular or juxtapillary mass, which flatly elevated into the vitreous body. In one case, the presence of choroidal neovascularization (CNV) in the tumor area was noted, in another – retinal detachment on the basis of the CO. In the ultrasonic B-scan, the CO looked like a high acoustic signal mining formation, giving a shadow into the retrobulbar space. According to CT scans in all patients, the osteoma looked like a plaque of bone density in the choroid. As a result of the treatment in both patients, the height of the foci decreased from 0.77 and 1.8 mm to 0.5 and 1 mm, respectively. In addition, there was a significant reduction in the number of newly formed vessels. In patients under dynamic, no changes were detected.

Conclusion: CO has a polymorphic clinical picture, the manifestations of which depend on the location of the tumor and the complications caused by it. Auxiliary diagnostic methods are B-scan, optical coherent tomography and CT scans of the orbits. In most cases, CO requires only dynamic observation. In such complications as CNV and the detachment of neuroepithelium, the treatment is aimed at reducing the number of newly formed vessels, reducing exudation and serous detachment of the retina to restore the maximum possible visual functions of the eye.

Keywords: Choroidal osteoma, choroidal neovascularization, detachment of neuroepithelium, thermotherapy, angiogenesis inhibitors.

Download file:


References
  1. Williams AT, Font RL, Van Dyk HL, Riekhof FT. Osseous choristoma of the choroid simulating choroidal melanoma: association with a positive 32P test. Arch Ophthalmol. 1978;96:1874-7.
  2. Gass JD, Guerry RK, Jack RL, Harris G. Choroidal osteoma. Arch Ophthalmol. 1978;96:428-35.
  3. Shields CL, Sun H, Demirci H, Shields JA. Factors predictive of tumor growth, tumor decalcification, choroidal neovascularization, and visual outcome in 74 eyes with choroidal osteoma. Arch Ophthalmol. 2005;123:1658-66.
  4. Buettner H. Spontaneous involution of a choroidal osteoma. Arch Ophthalmol. 1990;108:1517-8.
  5. Katz RS, Gass JM. Multiple choroidal osteomas developing in associationwith recurrent orbital inflammatory pseudotumor. Arch Ophthalmol. 1983;101:1724-7.
  6. Arrigo A, Pierro L, Sacconi R, Querques G, Bandello F. Bilateral choroidal osteoma complicated by bilateral choroidal neovascularization. Ophthalmic Surgery Lasers Imaging Retina. 2019;50(6):398-400.
  7. DePotter P, Shields JA, Shields CL. Magnetic resonance imaging of chorioidal osteoma. Retina. 1991;11:221-3.
  8. Astakhov YuS, Potemkin VV, Marchenko OA, Belekhova SG, Ovnanyan AYu. Choroidal osteoma. Ophthalmology Journal. 2016;9(3):77-81
  9. Shields CL, Materin MA, Mehta S, Foxman BT, Shields JA. Regression of extrafoveal choroidal osteoma following phtodynamic therapy. Arch Ophthalmol. 2008;126:135-7.
  10. Shukla D, Tanawade RG, Ramasamy K. Transpupillary thermotherapy for subfoveal choroidal neovaskular membrane in choroidal osteoma. Eye. 2006;20(7):6845-7.
  11. Aylward GW, Chang TS, Paulter SE, Gass JDM. A long-term follow-up of choroidal osteoma. Arch Ophthalmol. 1998;116:1337-41.
  12. Morris RJ, Prabhu VV, Shah PK, Narendran V. Combination therapy of low-fluence photodynamic therapy and intravitreal ranibizumab for choroidal neovascular membrane in choroidal osteoma. Indian J Ophthalmol. 2011;59(5):394-6.
  13. Ahmadien H, Vafi N. Dramatic response of chorioidal neovascularization associated with chorioidal osteoma to the intravitreal injection of bevacizumab. Graefe’s Archive for Clinical and Experimental Ophthalmology. 2007;245(11):1731-33..

Authors' information:


Yarovoy Andrey Aleksandrovich
Doctor of Medical Sciences, Head of the Department of Ophthalmo-Oncology and Radiology, S. Fyodorov Eye Microsurgery Federal State Institution
ORCID ID: 0000-0003-2219-7054
Author ID: 572962
SPIN: 9401-4489
E-mail: yarovoyaa@yandex.ru

Yarovaya Vera Andreevna
Ophthalmologist, Postgraduate Student, Department of Ophthalmo-Oncology and Radiology, S. Fyodorov Eye Microsurgery Federal State Institution
Author ID: 980888
SPIN: 4000-0180
E-mail: verandreevna@gmail.com

Astarkhanova Diana Sabirovna
Fellow, Department of Ophthalmo-Oncology and Radiology, S. Fyodorov Eye Microsurgery Federal State Institution
ORCID ID: 0000-0002-1290-8687
E-mail: dianamntk@mail.ru

Kleyankina Svetlana Sergeevna
Ophthalmologist, Oncologist, S. Fyodorov Eye Microsurgery Federal State Institution
Author ID: 680942
SPIN: 2346-0684
E-mail: oncologymntk@yandex.ru

Information about support in the form of grants, equipment, medications

The authors did not receive financial support from manufacturers of medicines and medical equipment

Conflicts of interest: No conflict

Address for correspondence:


Yarovaya Vera Andreevna
Ophthalmologist, Postgraduate Student, Department of OphthalmoOncology and Radiology, S. Fyodorov Eye Microsurgery Federal State Institution

127486, Russian Federation, Moscow, Beskudnikov Boulevard, 59A

Tel.: +7 (499) 4888715

E-mail: yarovoyaa@yandex.ru