Pathophysiology
doi: 10.25005/2074-0581-2018-20-2-3-224-229
USE OF ACCELERATED METHODS OF DETECTION OF MULTI-DRUG RESISTANT EXTRAPULMONRY TUBERCULOSIS

D.K. Kozhomkulov1, K.M. Mukanbaev2, M.D. Kozhomkulov1, T. Kh. Kudayberdiev2, О.R. Botobekov1, E.A. Baynazarov1

1Department of Bones and Joints Tuberculosis Surgery, National Center for Phthisiology, Bishkek, Kyrgyz Republic
2Department of Extrapulmonary Surgery, National Center for Phthisiology, Bishkek, Kyrgyz Republic

Objective: To evaluate modern diagnostic methods in identifying extrapulmonary forms of tuberculosis (EPT) with drug resistance.

Methods: To examine the time limits and identification of circumstances and diagnostics in EPT considered TB-06 registration forms for 2017, № 003/U (case history) of the 56 primary diagnosed patients registered for 2017-2018 in the National Center for Phthisiology.

Results: The incidence of EPT in Kyrgyzstan in 2017 was 23.9 per 100 thousand of the population. According to TB-06 forms, extrapulmonary tuberculosis is only 1650 cases. 862 sowings were carried out, of which 503 were negative (58%). Positive results of sowings were 359 (42%). In 333 cases, a drug sensitivity test was performed: resistant forms were 192 (57.6%) and sensitive – 141 (42.4%) cases.

Conclusion: From modern methods noted the high use of BactecMGIT and molecular genetic methods of research, which shortens the diagnosis time and promotes to the timely start of the treatment process.

Keywords: Tuberculosis, extrapulmonary, bones and joints, urogenital, peripheral lymph nodes, abdominal, multiple drug resistance.

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References
  1. Shevchenko SYu, Kulchavenya EV, Briярatyuk EV, Khomyakov VT, Kholbotin DP. Opredelenie urovnya nastorozhennosti v otnoshenii mochepolovogo tuberkulyoza u spetsialistov razlichnogo profilya [Deter-mination of the level of alertness in relation to urogenital tuberculosis in specialists of various profiles]. Tuberkulyoz i bolezni lyogkikh. 2017;10:76-80.
  2. Burlakov SV, Vishnevskiy AA. Komorbidnost’ i prognozirovanie riska vozniknoveniya posleoperatsionnykh oslozhneniy u bol’nykh tuberkulyoznym spondilitom [Comorbidity and prognosis of the risk of postoperative complications in patients with tuberculous spondilitis]. Tuberkulyoz i bolezni lyogkikh. 2016;11:50-5.
  3. Kolpakova TA, Pushkaryova EYu. Medikosotsial’nye faktory neblagopoluchiya bol’nykh s sochetannoy infektsiey tuberkulyoz i VICH infektsiey v Novosibirskoy oblasti i g. Novosibirsk [Medical and social factors of the disadvantage of patients with a co-infection of tuberculosis and HIV infections in the Novosibirsk Region and Novosibirsk]. Tuberkulyoz i bolezni lyogkikh. 2017;12:35-8.
  4. Sinitsyn MV, Belilovskiy EM, Sokolina IA, Reshetnikov MN, Tityukhina MV, Baturin OV. Vnelyogochnye lokalizatsii tuberkulyoza u bol’nykhVICH infektsiey [Extrapulmonary localization of tuberculosis in patients with HIV infection]. Tuberkulyoz i bolezni lyogkikh. 2017;11:19-24.
  5. Mushkin AYu, Belilovskiy EM, Pershin EM. Vnelyogochnyy tuberkulyoz v Rossiyskoy Federatsii: sopostavlenie nekotorykh ofitsial’nykh dannykh i rezul’tatov anketnogo skrininga [Extrapulmonary tuberculosis in the Russian Federation: comparison of some official data and the results of questionnaire screening]. Meditsinskiy al’yans. 2013;1:80-5.
  6. Zuban ON, LevashyovYuN, Skornyakov SN. Nefroureterektomiya v lechenii bol’nykh s tuberkulyozom pochek [Nephroureterectomy in the treatment of patients with kidney tuberculosis]. Tuberkulyoz i bolezni lyogkikh. 2013;2:29-35.
  7. Mordyk AV, Yakovleva AA, Nikolaeva IN, Leontyev VV. Aktual’nost’ problemy vnelyogochnogo tuberkulyoza v sovremennykh epidemiologicheskikh usloviyakh [The urgency of the problem of extrapulmonary tuberculosis in modern epidemiological conditions]. Tikhookeanskiy meditsinskiy zhurnal. 2015;7:140-1.
  8. Turitsa AA, Velichko KA, Baryshnikova DV, Ivanova OG, Mordyk AV. Patologiya pochek u detey, infitsirovannykh mikobakteriyami tuberkulyoza [Kidney pathology in children infected with mycobacteria tuberculosis]. Tuberkulyoz i bolezni lyogkikh. 2015;7:140-1.
  9. Vasilieva IA, Taran DV. Proekt po sboru i izucheniyu luchshikh primerov organizatsii lecheniya i klinicheskogo vedeniya bol’nykh tuberkulyozom, v tom chisle s mnozhestvennoy lekarstvennoy ustoychivost’yu vozbuditelya i sochetannym s VICH infektsiey [The project to collect and study the best examples of the organization of treatment and clinical management of tuberculosis patients, including those with multiple drug resistance of the causative agent and a combi-nation with HIV infection]. Tuberkulyoz i bolezni lyogkikh. 2014;1:1-6.
  10. Naryshkina SL, Revyakina OV, Alekseeva TV. Tuberkulyoz, sochetannyy s VICH infektsiey v Sibirskom federal’nom okruge v 2010-2012 gg [Tuberculosis, associated with HIV infection, in the Siberian Federal District in 2010-2012]. Tuberkulyoz i bolezni lyogkikh. 2014;5:50-4.
  11. Mukanbaev KM, Kadyrov AS, Usupbaev ACh. Rezektsiya pochki pri tuberkulyoznom porazhenii [Resection of the kidney for tuberculous le-sions]. Nauka, novye tekhnologii i innovatsii. 2016;10:76-80.
  12. Mukanbaev KM, Kulchavenya EV. Mochepolovoy tuberkulyoz u detey i podroskov v Respublike Kyrgyzstan [Genitourinary tuberculosis in children and adolescents in the Republic of Kyrgyzstan]. Tuberkulyoz i bolezni lyogkikh. 2013;9:43-6.
  13. Toktogonova AA. Chastota i kharakter pobochnykh reaktsiy na protivotuberkulyoznye preparaty vtorogo ryada u bol’nykh tuberkulyozom s mnozhestvennoy lekarstvennoy ustoychivostyu vozbuditelya [The frequency and nature of adverse reactions to anti-TB drugs in a number of patients with multidrug-resistant tuberculosis]. Tuberkulyoz i bolezni lyogkikh. 2017;10:63-7.
  14. Borisov SE, Bogorodskaya EM, Volchenkov GV, Kulchavenya EV, Maryandyshev AO, Skornyakov SN, i dr. Effektivnost’ i bezopasnost’ rezhima khimioterapii, vklyuchayushchego preparat SQ109, u bol’nykh tuberkulyozom lyogkikh s mnozhestvennoy lekarstvennoy ustoychivostyu vozbuditelya [The efficacy and safety of the chemother-apy regimen including SQ109 in patients with multidrug-resistant tuberculosis of the pathogen]. Tuberkulyoz i bolezni lyogkikh. 2018;3:6-16.
  15. Laushkina ZhA, Krasnov VA, Cherednichenko AG. Diagnosticheskaya znachimost’ testa Gene Xpert MTB-RIF vo vtiziatricheskoy praktike [Diagnostic significance of GeneXpertMTB-RIF in phthisiology practice]. Tuberkulyoz i bolezni lyogkikh. 2016;10:37-9.
  16. Salina TYu, Churkin SA, Morozova TI. Molekulyarno-geneticheskiy analiz i spektr mutatsiy v genakh katG, inhA, rpoB, kodiruyushchikh lekarstvennuyu ustoychivost’ k izoniazidu i rifampitsinu u bol’nykh tuberkulyozom i VICH infektsiey [Molecular genetic analysis and the spectrum of mutations in katG, inhA, rpoB genes encoding the drug resistance of isoniazid and rifampicin in patients with tuberculosis and HIV infection]. Tuberkulyoz i bolezni lyogkikh. 2016;8:54-9.
  17. Vakhrusheva DV, Eremeeva NI, Umpeleva TV, Belousova KV. Opyt primeneniya tekhnologii «TB test» v diagnosticheskom algoritme [Ex-perience of using the technology "TB-test" in the diagnostic algorithm]. Tuberkulyoz i bolezni lyogkikh. 2017;10:29-34.
  18. Litvinov VI, Safanova SG, Freyman GE, Selkova EP, Grenkova TA, Gusarova MP. Issledovanie mikobakteritsidnoy aktivnosti impul’snogo ul’trafioletovogo izlucheniya sploshnogo spectra [The study of mycobactericidal activity of pulsed ultraviolet radiation of the continuous spectrum]. Tuberkulyoz i bolezni lyogkikh. 2018;4:39-46.
  19. Shevchenko SYu, Kulchavenya EV. Informativnost’ proby s diaskintestom v skrininge mochepolovogo tuberkulyoza [Informative character of the sample with a diaskintest in the screening of urogenital tuberculosis]. Tuberkulyoz i bolezni lyogkikh. 2017;8:49-57.

Authors' information:

Kozhomkulov Dzhumabay Kozhomkulovich,
Candidate of Medical Sciences, Leading Researcher, Department of Bones and Joints Tuberculosis Surgery, National Center for Phthisiology

Mukanbaev Kasymbek Mukanbaevich,
Candidate of Medical Sciences, Leading Researcher, Department of Extrapulmonary Surgery, National Center for Phthisiology

Kozhomkulov Meder Dzhumabaevich,
Researcher, Department of Bones and Joints Tuberculosis Surgery, National Center for Phthisiology

Kudayberdiev Turatbek Khalmatovich,
Researcher, Department of Extrapulmonary Surgery, National Center for Phthisiology

Botobekov Oskon Rakhmatzhanovich,
Researcher, Department of Bones and Joints Tuberculosis Surgery, National Center for Phthisiology

Baynazarov Elchibek Abdulakhatovich,
Researcher, Department of Bones and Joints Tuberculosis Surgery, National Center for Phthisiology

Conflicts of interest: No conflict

Address for correspondence:

Kozhomkulov Dzhumabay Kozhomkulovich

Candidate of Medical Sciences, Leading Researcher, Department of Bones and Joints Tuberculosis Surgery, National Center for Phthisiology

720020, Kyrgyz Republic, Bishkek, Akhunbaev str., 90a

Tel.: (+996) 312 570925

E-mail: marat.abdievtbc@gmail.com

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