Pathophysiology
doi: 10.25005/2074-0581-2018-20-2-3-261-265
THE ROLE OF BIOCHEMICAL BLOOD ANALYSIS IN ACTIVITY VERIFICATION OF PULMONARY TUBERCULOSIS

Kh.R. Nasyrdzhanova1, A.M. Saburova1, U.Yu. Sirodjidinova2, M.S. Makhsudova1

1Department of Biochemistry, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan
2Department of Phthisiopulmonology, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan

Objective: To study the interconnection of inflammatory process of vessels endothelium with biochemical changes in verification of the pulmonary tuberculosis (PTB) diagnosis.

Methods: Results of a study of 56 PTB patients are given in the age of 18-50 years, 26 of them with a drug-resistant (DR) form of PTB and 30 with a drug-sensitive (DS) form of PTB. The status of the vessels endothelium was judged by the amount of C-reactive protein (CRP), fibrinogen, and Willebrand factor.

Results: The studies have shown a significant increase in the content of CRP (4.22±0.13), fibrinogen (4.21±0.21) and Willebrand factor (114.0±2.5) in patients with DR PTB. The received data indicate that the course of a specific process of patients of PTB with extensive DR is more severe than in patients with DS PTB. The DR PTB is accompanied by the development of the syndrome of a systemic inflammatory response, whose manifestation is interrelated with the severity of the patient's condition. The syndrome of a systemic inflammatory response is manifested by an increase in the blood serum of the C-reactive protein, fibrinogen, and Willebrand factor. The values ​​of CRP within 4-5 mg/l are an early indicator of the process activity.

Conclusion: As a diagnostic test for PTB can be used to determine the status of endothelium blood vessels criteria for which are elevated levels of CRP, fibrinogen, and Willebrand factor.

Keywords: Tuberculosis, biochemical study, endothelium condition, C-reactive protein, fibrinogen, Willebrand factor.

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Authors' information:

Nasyrdzhanova Khursand Rakhimovna,
Assistant of the Department of Biochemistry, Avicenna Tajik State Medical University

Saburova Anna Mukhamedovna,
Doctor of Biological Sciences, Full Professor, Professor of the Department of Biochemistry, Avicenna Tajik State Medical University

Sirodjidinova Umrniso Yusupovna,
Doctor of Medical Sciences, Full Professor, Professor of the Department of Phthisiopulmonology, Avicenna Tajik State Medical University

Makhsudova Musallama Salikhovna,
Assistant of the Department of Biochemistry, Avicenna Tajik State Medical University

Conflicts of interest: No conflict

Address for correspondence:

Saburova Anna Mukhamedovna

Doctor of Biological Sciences, Full Professor, Professor of the Department of Biochemistry, Avicenna Tajik State Medical University

734003, Republic of Tajikistan, Dushanbe, Rudaki Ave., 139

Tel.: (+992) 917 241175

E-mail: 20@tajmedun.tj

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