Traumatology
doi: 10.25005/2074-0581-2017-19-4-520-523
INVESTIGATION OF CALCIUM-PHOSPHORIC EXCHANGE IN WOMEN WITH THE MENOPAUSE STATE SUFFERING FROM OSTEOARTHROSIS AND CONCOMITANT OSTEOPENIC SYNDROME

A.S. Kaysinova1, A.B. Lepshokova1, T.B. Menshikova1, N.K. Akhkubekova1, L.A. Cherevashchenko1, R.M. Mallaeva2

1Federal State Budgetary Institution «Pyatigorsk State Scientific Research Institute of Balneology» of the Federal Medical-Biological Agency, Pyatigorsk, Russia
2Federal State Budget Educational Institution of Higher Professional Education «Dagestan State Medical University» of the Ministry of Health of the Russian Federation, Makhachkala, Russia

Objective: To study changes in calcium-phosphorus metabolism, bone metabolism and mineral bone density in osteoarthritis with the concomitant osteopenic syndrome in women with the menopause state.

Methods: We examined 40 women in the state of menopause (50-60 years), patients with osteoarthrosis of the hip joints, with a duration of disease of 3-5 and more years (the main group), and 20 healthy women of the same age (control group).

Results: An increase (p<0.05) of the serum level of the C-terminal telopeptide of type I collagen, a marker of bone resorption, a predominance speed of bone resorption rate over bone formation, while no significant deviations in the level of phosphatemia and calcemia were observed with a tendency to decrease activity of alkaline phosphatase and the level of osteocalcin – markers of bone formation in serum. In addition, osteopenia has been noted in various parts of the skeleton: in the spine with a predominantly trabecular type of bone structure.

Conclusion: The revealed multiple correlation relationships of the main characteristic indicators of osteoarthrosis with markers of bone resorption once again testify the comorbidity of osteoarthritis with osteoporosis.

Keywords: Osteoarthritis, osteopenic syndrome, calcium-phosphorus metabolism, bone metabolism, menopause.

Download file:

References
  1. Kapustina EV, Bolshakova TYu, Sharaykina EP, Chupakhina VA. Somatometricheskaya kharakteristika zhenshchin s osteoartrozom i osteoporozom po materialam Kraevogo tsentra osteoporoza [Somatometric characteristics of women with osteoarthritis and osteoporosis according to the materials of the regional center of osteoporosis]. Sibirskoe meditsinskoe obozrenie. 2012;6:34-5.
  2. Bergink A, Uitterlinden AG, Van Leeuwen JP, Buurman CJ, Hofman A, Verhaar JA, et al. Vitamin D status, bone mineral density, and the development of radiographic osteoarthritis of the knee: The Rotterdam Study. J Clin Rheumatol. 2009;15(5):230-7.
  3. Setty N. Underestimated fracture probability in patients with unilateral hip osteoarthritis as calculated by FRAX. J Clin Densitom. 2011;14(4):447-52.
  4. Dedov II, Melnichenko GA, Belaya ZhE, Rozhinskaya LYa. Osteoporoz – ot redkogo simptoma endokrinnykh bolezney do bezmolvnoy epidemii XX-XXI veka [Osteoporosis – from a rare symptom of endocrine diseases to a silent epidemic of the XX-XXI century]. Problemy endokrinologii. 2011;1(57):35-45
  5. Olyunin YuA. Rekomendatsii EULAR/EFORT po diagnostike i nachal’nomu etapu vedeniya bol’nykh s ostroy ili nedavno voznikshey pripukhlost’yu kolennogo sustava [EULAR/EFORT recommendations for diagnosis and initial phase of management of patients with acute or recent swelling of the knee]. Sovremennaya revmatologiya. 2010;4:7-10.
  6. Romanov GN, Rudenko EV. Sovremennye problemy vozrast-assotsiirovannykh zabolevaniy: osteoartroz i osteoporoz [Modern problems of age-associated diseases: osteoarthritis and osteoporosis]. Meditsinskie novosti. 2012;8:26-9.
  7. Menshikova TB, Zhukova EV. Effektivnost’ al’fa-terapii pri osteoartroze [Effectiveness of alpha therapy in osteoarthritis]. Tsitokiny i vospalenie. 2011;2(10):99-100.
  8. Akhkubekova NK, Kaysinova AS, Teryoshin AT. Radonoterapiya v kurortnom lechenii bol’nykh s funktsional’noy giperprolaktinemiey [Radon therapy in the treatment of patients with functional hyperprolactinemy]. Voprosy kurortologii, fizioterapii i lechebnoy fizicheskoy kul’tury. 2010;2:22-4.
  9. Wright NC, Lisse JR, Walitt BT, Eaton CB, Chen Z. Arthritis increases the risk for fractures – results from the Women’s Health Initiative. J Rheumatol. 2011;38(8):1680-8.
  10. Kapustina EW, Sharaykina ER, Bolshakova TYu, Chupahina VA. Features of joint lesions in women with comorbidity of osteoarthritis and osteoporosis based on the constitution. Int J Biomed. 2012;3;183-6.
  11. Efimenko NV, Akhkubekova NK, Babyakin AF. Diagnostika i lechenie bol’nykh s sindromom pervichnogo «pustogo» turetskogo sedla na sanatornokurortnom etape [Diagnosis and treatment of patients with the syndrome of the primary «empty» Turkish saddle at the sanatorium-and-spa stage]. Voprosy kurortologii, fizioterapii i lechebnoy fizicheskoy kul’tury. 2010;2:7-10.
  12. Kaznacheeva TV, Osipova AA. Sovremennye metody opredeleniya mineral’noy plotnosti kostnoy tkani [Modern methods for determining bone mineral density]. Problemy reproduktsii. 2007;6:57-61.
  13. Svinina SA, Kirpikova MN, Nazarova OA, Guryanov AV, Beloselskiy NN. Razrabotka sposoba diagnostiki osteoporoza u zhenshchin v postmenopauze s bol’yu v spine. Vestnik Ivanovskoy meditsinskoy akademii. 2015;19(4):87- 92.
  14. Turovskaya EF, Alekseeva LI, Filatova EG, Nasonov EL. Znachenie disfunktsii tsentral’nykh bolevykh sistem v podderzhanii khronicheskoy boli u patsientov s osteoartrozom [The importance of dysfunction of central pain systems in maintaining chronic pain in patients with osteoarthritis]. Rossiyskiy zhurnal boli. 2014;3-4:20-4.
  15. Shostak NA, Pravdyuk NG. Bol’ v spine, assotsiirovannaya s os-teoporozom: algoritm vedeniya, podkhody k terapii [Back pain associated with osteoporosis: algorithm of management, approaches to therapy]. Klinitsist. 2012;1:86-91.

Authors' information:

Kaysinova Agnessa Sardoevna,
Doctor of Medical Sciences, Deputy Director for Curative Work, Pyatigorsk State Scientific Research Institute of Balneology

Lepshokova Amina Borisovna,
Postgraduate student, Pyatigorsk Clinic of Pyatigorsk State Scientific Research Institute of Balneology

Menshikova Tatyana Borisovna,
Candidate of Medical Sciences, Leading Researcher of the Scientific Department of the Revival Rheumatology, Pyatigorsk Clinic of the Pyatigorsk State Research Institute of Balneology

Akhkubekova Nelly Kaytmurzaevna,
Doctor of Medical Sciences, Senior Researcher of the Scientific Department of the Physical and Rehabilitation Medicine, Pyatigorsk Clinic of the Pyatigorsk State Research Institute of Balneology

Cherevashchenko Lyubov Anatolievna,
Doctor of Medical Sciences, Full Professor, Senior Researcher of Pyatigorsk Clinic of the Pyatigorsk State Research Institute of Balneology

Mallaeva Raziyat Mudunovna,
Candidate of Medical Sciences, Assistant of the Department of Clinical Pharmacology of the Dagestan State Medical University

Conflicts of interest: No conflict

Address for correspondence:

Kaysinova Agnessa Sardoevna

Doctor of Medical Sciences, Deputy Director for Curative Work, Pyatigorsk State Scientific Research Institute of Balneology

357500, Russian Federation, Pyatigorsk, Kirova Ave., 30

Tel.: (+7) 879 3335766

E-mail: orgotdel@gniik.ru

Materials on the topic:
  1. RISK FACTORS ASSOCIATED WITH IN-HOSPITAL MORTALITY AND PREDICTING OUTCOMES IN SEVERE ACUTE COMPOSITE TISSUE INJURIES
  2. COMPARATIVE EVALUATION OF THE RESULTS OF TREATMENT OF UNSTABLE UNCOMPLICATED SPINAL FRACTURES
  3. PREVENTION OF POSTOPERATIVE COMPLICATIONS OF CALCANEUS FRACTURES
  4. AUTO-DYNAMIC INTRAMEDULLARY OSTEOSYNTHESIS FOR FEMUR FRACTURES AND CONSEQUENCES OF INJURIES
  5. COMPREHENSIVE PREVENTION OF INSTABILITY IN HIP REPLACEMENT FOR HIP FRACTURES AND THEIR CONSEQUENCES IN POSTMENOPAUSAL OSTEOPOROSIS IN MULTIPAROUS WOMEN
  6. HIP REPLACEMENT FOR HIP FRACTURES AND THEIR CONSEQUENCES IN POSTMENOPAUSAL OSTEOPOROSIS IN MULTIPAROUS WOMEN
  7. EVALUATION OF THE EFFICIENCY OF ANTIRESORPTIVE THERAPY FOR OSTEOPOROSIS IN MULTIPAROUS WOMEN
  8. THE RESULTS OF TOTAL HIP JOINT ENDOPROSTHESIS FOR CONGENITAL HIP DISLOCATION
  9. COMPLICATIONS OF HIP JOINT ENDOPROSTHESIS
  10. OPTIMIZING MEDICAL REHABILITATION IN TRAUMAS OF LOCOMOTORIUM IN CONDITIONS OF POLYCLINIC

◄ Back to the list