Case Reports
doi: 10.25005/2074-0581-2020-22-3-498-503
DIFFICULTIES IN THE MANAGEMENT OF LARGE ASYMPTOMATIC PITUITARY ADENOMA, DETECTED DURING DIAGNOSTIC OF THE CENTRAL GYRUS REGION MENINGIOMA

A.S. Nechaeva, L.N. Maslova, L.M. Tsentsiper, B.I. Safarov

Polenov Russian Research Institute of Neurosurgery, Saint Petersburg, Russian Federation

Multiple intracranial tumors with different histological types diagnosed in the same patient are rare. The combination of meningiomas and pituitary adenomas in most cases concerns patients who received radiation therapy for pituitary adenomas. In our observation, the giant meningioma of the central gyrus area and large asymptomatic pituitary adenoma were diagnosed. As a result of surgical treatment performed in 2 stages, the total removal of the large pituitary adenoma was not achieved, which raised the question of finding alternative non-surgical methods of patient management. According to the results of an additional immunohistochemical study, the presence of somatostatin receptors 2a (SSTR2a) was revealed both in the pituitary adenoma and in the meningioma, which makes it possible to consider the issue of further treatment of pituitary adenoma with somatostatin receptor agonists and might reduce the risk of relapse and meningioma in the patient.

Keywords: Meningioma, pituitary adenoma , multiple intracranial tumors, asymptomatic macroadenoma, somatostatin receptors.

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Authors' information:

Nechaeva Anastasiya Sergeevna
Neurosurgeon, Polenov Russian Research Institute of Neurosurgery
ORCID ID: 0000-0001-9898-5925
E-mail: nastja-nechaeva00@mail.ru

Maslova Lyudmila Nikolaevna
Candidate of Medical Sciences, Neurologist, Senior Researcher of the Department of Neurooncology, Polenov Russian Research Institute of Neurosurgery
ORCID ID: 0000-0002-4612-8363
E-mail: lydmmasl@mail.ru

Tsentsiper Lyubov Markovna
Candidate of Medical Sciences, Endocrinologist, Resuscitation Anesthetist, Senior Researcher of the Department of Neuroprotection and Metabolic Disorders, Polenov Russian Research Institute of Neurosurgery
ORCID ID: 0000-0001-7527-7707
E-mail: lmt1971@yandex.ru

Safarov Bobir Ibragimovich
Candidate of Medical Sciences, Head of the Neurosurgery Department № 4, Polenov Russian Research Institute of Neurosurgery
ORCID ID: 0000-0002-2369-7424
E-mail: safarovbob@mail.ru

Information about support in the form of grants, equipment, medications

The authors did not receive financial support from manufacturers of medicines and medical equipment

Conflicts of interest: No conflict

Address for correspondence:

Nechaeva Anastasiya Sergeevna
Neurosurgeon, Polenov Russian Research Institute of Neurosurgery

191014, Russian Federation, Saint Petersburg, Mayakovsky str., 12

Теl.: +7 (952) 2459351

Е-mail: nastja-nechaeva00@mail.ru

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