Pharmacology
doi: 10.25005/2074-0581-2019-21-3-455-466
ABOUT SIMPLE ANTI-DIABETIC REMEDIES BY AVICENNA

M.U. Sharofova1,2

1Center for Research on Innovative Technologies under the Academy of Sciences of the Republic of Tajikistan, Dushanbe, Republic of Tajikistan
2Institute of Avicenna’s Medicine and Pharmacology, Dushanbe, Republic of Tajikistan

Objective: To study the principles of the use of anti-diabetic drugs in the medical system of Avicenna based on the features of the «mizaj» of medicines.

Methods: For the analysis the understanding of the Avicenna processes of diabetes genesis, the treatment of diabetes and its prevention, screening of his works was carried out: all the books of the five-volume «Canon of Medicine», medical treatises «Al-Vohiya» («Recipe Code»), «Ash-Shifa» («Book of Healing»), «The Treatise on Medical Care», «The Treatise on Medicines», «The Treatise on Heart Medication», «The Treatise on Pulse».

Results: Screening of Avicenna’s works allowed allocating 84 medicines used for diabetes therapy and prevention. Most of the remedies have plant origins, including gums and gum-resins. The list also contains mineral and animal remedies. Most anti-diabetic remedies on Avicenna have «hot nature», i.e. warming and leaching properties. Cooling action with «cold nature» products was aimed at reducing the body’s fluid loss in diabetes. The combination of Avicenna’s various remedies recommended balances their effects on the body and alternating their use will add the correction of the «mizaj» in diabetes.

Conclusion: Treatment of diabetes, as a condition of poly-morbidity with numerous metabolic disorders, requires taking into account the relationship between multicomponent phytochemical composition, the versatility of the range of therapeutic actions of natural origin remedies and the features of the «mizaj» of the patient’s body

Keywords: «Canon of Medicine», antidiabetic medicines, Avicenna, «mizaj», «hot nature».

Download file:

References
  1. Abu Ali ibn Sina (Avicenna). Sochineniya. Kanon vrachebnoy nauki. Kniga vtoraya [Writings. Canon of Medicine. Book two]. Dushanbe, RT: Donish; 2012:13, 29-40, 45-7
  2. Abu Ali ibn Sina. Alvokhiya. Izbrannye proizvedeniya [Alvohia. Selected Works]. Dushanbe, RT: Irfon; 1980:317-86 (in Tajik).
  3. Abu Ali ibn Sina (Avicenna). Traktat о lekarstvennykh sredstvakh. Sochineniya [Treatise on drugs. Writings]. Dushanbe, RT: Donish;2008;825-953.
  4. Abu Ali ibn Sina (Avicenna). Traktat о vrachevanii. Sochineniya [Treatise on healing. Writings]. Dushanbe, RT: Donish; 2008:583-678.
  5. Abu Ali ibn Sina (Avicenna). Traktat о pul’se – angiologiya. Sochineniya [Treatise on the pulse – angiology. Writings]. Dushanbe, RT: Donish; 2008: 679-700.
  6. Abu Ali ibn Sina (Avicenna). Traktat о serdechnykh lekarstvakh. Sochineniya [Treatise on heart medications. Writings]. Dushanbe, RT: Donish; 2008:701-64.
  7. Abu Ali ibn Sina (Avicenna). Sochineniya. Kanon vrachebnoy nauki. Kniga pervaya [Canon of Medicine. Book one]. Dushanbe, RT: Donish; 2010. 735 p.
  8. Abu Ali ibn Sina (Avicenna). Sochineniya. Kanon vrachebnoy nauki. Kniga vtoraya [Canon of Medicine. Book two]. Dushanbe, RT: Donish; 2012: 958 p.
  9. Nuraliev YuN, Sharofova MU, Sagdieva ShS. O sushchnosti i tyazhyolykh posledstviyakh taktiki terapii sakharnogo diabeta po printsipu «podobnoe podobnym» [Essence and severe consequences of therapy tactics of diabetes mellitus by principle «like cures like»]. Vestnik Avitsenny [Avicenna Bulletin]. 2015;3:151-6.
  10. Sharofova M, Aldybiat I, Sagdieva Sh, Burkhonova N, Nuraliev Yu, Rahimi F, Mirshahi M. Molecular approach to determine the hot and cold temperaments in plants according Avicenna concepts, the role of magnesium. Vestnik Avitsenny [Avicenna Bulletin]. 2018;20(4):421-6. Available from: https://doi. org/10.25005/2074-0581-2018-20-4-421-426.
  11. Shestakova MV. Disfunktsiya endoteliya – prichina ili sledstvie metabolicheskogo sindroma? [Endothelial dysfunction – cause or consequence of metabolic syndrome?]. RMZH. 2001;9(2):88-101.
  12. Shestakova MV. Kommentarii endokrinologa k rekomendatsiyam po sakharnomu diabetu, prediabetu i serdechno-sosudistym zabolevaniyam ESC-EASD 2007 [Comments of endocrinologist to recommendations for diabetes, pre-diabetes and cardiovascular diseases ESC-EASD 2007]. Sakharnyy diabet. 2008;11(1):97-9.
  13. Dedov II. Innovatsionnye tekhnologii v lechenii i profilaktike sakharnogo diabeta i ego oslozhneniy [Innovative technologies in the treatment and prevention of diabetes mellitus and its complications]. Sakharnyy diabet. 2013;3:2-10.
  14. Dedov II. Initsiatsiya i intensifikatsiya sakharosnizhayushchey terapii u bol’nykh sakharnym diabetom 2 tipa: obnovlenie konsensusa soveta ekspertov Rossiyskoy assotsiatsii endokrinologov [Initiation and intensification of glucose-lowering therapy in patients with type 2 diabetes mellitus: update of the consensus of the board of experts of the Russian Association of Endocrinologists]. Sakharnyy diabet. 2015;1:5-23.
  15. Ovchinnikov PN. (red.) Flora Тadzhikskoy SSR. Тоm VIII [Flora of the Tajik SSR. Volume VIII]. Moscow, RF: Izdatel’stvo Akademii nauk SSSR; 1986. 520 p.
  16. Ovchinnikov PN. (red.) Flora Тadzhikskoy SSR. Тоm IX [Flora of the Tajik SSR. Volume IX]. Leningrad, RF: Nauka; 1988. 568 p.
  17. Fyodorov AA. (red.) Rastitel’nye resursy SSSR. Tsvetkovye rasteniya, ich khimicheskiy sostav, ispol’zovanie. Semeystva Magnoliaceae-Limoniaceae [Plant resources of the USSR. Flowering plants, their chemical composition, use. Magnoliaceae-Limoniaceae families]. Leningrad, RF: Nauka. Leningradskoe otdelenie; 1985. 464 p.
  18. Sokolov PD. (red.) Rastitel’nye resursy SSSR. Tsvetkovye rasteniya, ich khimicheskiy sostav, ispol’zovanie. Semeystva Paeoiaceae-Thymelaeaceae [Plant resources of the USSR. Flowering plants, their chemical composition, use. Paeoiaceae-Thymelaeaceae families]. Leningrad, RF: Nauka. Leningradskoe otdelenie; 1986. 336 p.
  19. Sokolov PD. (red.) Rastitel’nye resursy SSSR. Tsvetkovye rasteniya, ich khimicheskiy sostav, ispol’zovanie. Semeystva Hydrangeaceae-Haloragaceae [Plant resources of the USSR. Flowering plants, their chemical composition, use. Hydrangeaceae-Haloragaceae families]. Leningrad, RF: Nauka. Leningradskoe otdelenie; 1987. 328 p.
  20. Sokolov PD. (red.) Rastitel’nye resursy SSSR. Tsvetkovye rasteniya, ich khimicheskiy sostav, ispol’zovanie. Semeystva Rutaceae-Elaeagnaceae [Plant resources of the USSR. Flowering plants, their chemical composition, use. Rutaceae-Elaeagnaceae families]. Leningrad, RF: Nauka. Leningradskoe otdelenie; 1988. 356 p.
  21. Sokolov PD. (red.) Rastitel’nye resursy SSSR. Tsvetkovye rasteniya, ich khimicheskiy sostav, ispol’zovanie. Semeystva Caprifoliaceae-Plantaginaceae [Plant resources of the USSR. Flowering plants, their chemical composition, use. Caprifoliaceae-Plantaginaceae families]. Leningrad, RF: Nauka. Leningradskoe otdelenie; 1990.328 p.
  22. Sokolov PD. (red.) Rastitel’nye resursy SSSR. Tsvetkovye rasteniya, ich khimicheskiy sostav, ispol’zovanie. Semeystva Hippuridaceae-Lobeliaceae [Plant resources of the USSR. Flowering plants, their chemical composition, use. Hippuridaceae-Lobeliaceae families]. Saint Petersburg, RF: Nauka. Sankt-Peterburgskoe otdelenie; 1991. 200 p.
  23. Sokolov PD. (red.) Rastitel’nye resursy SSSR. Tsvetkovye rasteniya, ich khimicheskiy sostav, ispol’zovanie. Semeystvo Asteraceae [Plant resources of the USSR. Flowering plants, their chemical composition, use. Asteraceae family]. Saint Petersburg, RF: Nauka; 1993. 349 p.
  24. Khodzhimatov М. Dikorastushchie lekarstvennye rasteniya Tadzhikistana. [Wild plants of Tajikistan]. Dushanbe, RT: Irfon; 1989. 368 p.
  25. Sokolov SYa, Zamotaev IP. Spravochnik po lekarstvennym rasteniyam [Medicinal plant handbook]. Moscow, RF: Meditsina; 1984. 500 p.
  26. Yordanov D, Nikolaev P, Boychanov A. Fitoterapiya [Phytotherapy]. Sofia, Bulgaria: Meditsina i fizkul’tura; 1970. 323 p.
  27. Nuraliev YuN. Lekarstvennye rasteniya [Medicinal plants]. Dushanbe, RT: Maorif; 1989. 288 p.
  28. Nikonov GK, Manuylov BM. Osnovy sovremennoy fitoterapii [Fundamentals of modern phytotherapy]. Moscow, RF: Meditsina; 2014. 334 p.
  29. Sokolov SYa. Fitoterapiya i fitofarmakologiya: Rukovodstvo dlya vrachey [Phytotherapy and phytopharmacology: a guide for doctors]. Мoscow, RF: Meditsinskoe informatsionnoe agentstvo; 2000. 976 p.
  30. Dzyuba VF, Nikolaevskiy VA, Shcherbakov VM, Korenskaya IM. Lekarstvennye rasteniya v fitoterapii: practicheskoe posobie [Medicinal plants in phytotherapy: a practical guide]. Voronezh, RF: Izdatel’stvo VGU; 2004. 83 p.
  31. Barnaulov OD. Detoksikatsionnaya fitoterapiya ili protivoyadnye svoystva lekarstvennykh rasteniy [Detoxification phytotherapy or antidote properties of medicinal plants]. Мoscow, RF: Politekhnika; 2007. 416 p.
  32. Vinogradova ТА, Gazhyov BN, Vinogradov VM, Martynov VK. Polnaya entsiklopediya prakticheskoy fitoterapii. Pod red. Gazhyova BN. [Full encyclopedia of practical phytotherapy]. Мoscow, RF: Olma-Press; Saint Petersburg, RF: Neva, Valeri SPD; 1998. 640 p.
  33. Sharofova MU. Opyt Avitsenny i vozmozhnosti uluchsheniya terapii sakharnogo diabeta [Avicenna’s experience and opportunities for improving the treatment of diabetes]. Obzory po klinicheskoy farmakologii i lekarstvennoy terapii. 2017;15(1):58-67.

Authors' information:

Sharofova Mizhgona Umedzhonovna
Candidate of Medical Sciences, Head of the Biotechnology Laboratory, Department of Innovative Pharmacology and Experimental Medicine of the Center for Research in Innovative Technologies, the Academy of Sciences of the Republic of Tajikistan; Director of Institute of Avicenna’s Medicine and Pharmacology
ORCID ID: 0000-0002-7155-7194

Information about support in the form of grants, equipment, medications

The author did not receive financial support from manufacturers of medicines and medical equipment.

Conflicts of interest: No conflict

Address for correspondence:

Sharofova Mizhgona Umedzhonovna
Candidate of Medical Sciences, Head of the Biotechnology Laboratory, Department of Innovative Pharmacology and Experimental Medicine of the Center for Research in Innovative Technologies, the Academy of Sciences of the Republic of Tajikistan; Director of Institute of Avicenna’s Medicine and Pharmacology

734025, Republic of Tajikistan, Dushanbe, 229/3 Ayni Street

Tel.: +992 (918) 614123

E-mail: mijgona72@mail.ru

Materials on the topic:
  1. IN VITRO EVALUATION OF ANTITHROMBOTIC AND ANTICOAGULANT ACTIVITY OF HERBAL SOURCES
  2. ANALYSIS OF ANTIBACTERIAL AND FUNGICIDAL ACTIVITY OF ALLIUM OSHANINII AND ALLIUM SUWOROWII DEPENDING ON THE ALTITUDE OF PLANT GROWTH
  3. STUDY OF ANTIBACTERIAL ACTIVITY OF EXTRACTS OF DIFFERENT SPECIES OF THE GENUS Allium GROWING IN TAJIKISTAN
  4. ANTIBACTERIAL, ANTIFUNGAL, ANTIOXIDANT ACTIVITY AND POLYPHENOL CONTENT OF AERIAL PARTS AND BULBS OF ALLIUM SCHUGNANICUM
  5. DEVELOPMENT OF THE COMPOSITION AND TECHNOLOGY OF COATED TABLETS WITH RHEUM CORDATUM LOSINSK. EXTRACT
  6. COMPARATIVE CHARACTERISTICS OF ANTIBACTERIAL ACTIVITY OF PLANTS GROWING IN THE CENTRAL PART OF THE REPUBLIC OF TAJIKISTAN
  7. ANTI-TUMOR ACTIVITY OF DRY EXTRACT PADUS GRAYANAE MAXIM IN VITRO
  8. ANTIOXIDANT ACTIVITY AND CONTENT OF POLYPHENOLS IN ARTEMISIA SCOPARIA WALDST. ET KIT., GROWING UNDER THE CONDITIONS OF WESTERN PAMIR
  9. MOLECULAR APPROACH TO DETERMINE THE HOT AND COLD TEMPERAMENTS IN PLANTS ACCORDING AVICENNA CONCEPTS, THE ROLE OF MAGNESIUM

◄ Back to the list