N.Kh. Khamidov, A.A. Umarov, S.A. Umarova, H.K. Toirov
FEATURES OF REMODELLING OF THE LEFT VENTRICULAR MYOCARDIUM IN PATIENTS WITH ARTERIAL HYPERTENSION OF ELDERLY AGE WITH COMORBID DEPRESSION
Department of Internal Diseases № 2, Avicenna Tajik State Medical University, Dushanbe, Tajikistan
Objective: to examine the character of correlation and interaction of depressive disorders as well as the remodelling features of the left ventricle (LV) myocardium in elderly patients suffering from arterial hypertension (AH).
Methods: 70 persons aged 60 to 74 years were examined. The main group consisted of 40 patients with AH: 22 men (57.5%) and 18 women (42.5%). The control group included 30 essentially healthy individuals, identical in gender and age. Structural changes in the myocardium were studied by echocardiography.
Results: LV hypertrophy was significantly more common in hypertensive patients than in the control group (92.5% compared to 20%). Among the abnormalities of LV geometry in the main group, the leading place was occupied by concentric hypertrophy in 21 patients (52.5%), with eccentric hypertrophy was also significantly higher and was noted in 16 patients (40.0%). The LV ejection fraction in the average group exceeded 50%. However, when comparing individual data with indices of the control group, the falling tendency was noted (61.4±4.55 and 64.6±5.22, respectively). The same picture of the shortening of the anteroposterior size (ΔS%) of the LV (39.4±3.49 compared to 36.2±7.28). Significant differences occurred in the thickness of the posterior wall and interventricular septum.
Conclusions: The revealed structural changes in the heart with AH, the development of LV hypertrophy, and its remodelling assists to the diastolic and then systolic dysfunction of the heart.
Keywords: Arterial hypertension, depression, myocardial remodelling, elderly age.
pages - 172-176
Khamidov Nabidzhon Khamidovich, Corresponding Member of AS RT, Doctor of Medical Sciences, Full Professor, Professor of the Department of Internal Diseases № 2 of Avicenna TSMU
Umarov Ahmed Abubakirovich, Candidate of Medical Sciences, Associate Professor of the Department of Internal Diseases № 2 of Avicenna TSMU
Umarova Sitora Ahmedovna, Candidate of Medical Sciences, Assistant of the Department of Internal Diseases № 2 of Avicenna TSMU
Toirov Khisrav Kosimovich, Candidate of Medical Sciences, Assistant of the Department of Internal Diseases № 2 of Avicenna TSMU
Address for correspondence
Umarov Ahmed Abubakirovich
Candidate of Medical Sciences, Associate Professor of the Department of Internal Diseases № 2 of Avicenna TSMU
734003, Republic of Tajikistan, Dushanbe, Rudaki Ave., 139
Tel: (+992) 918 654804