Dermatovenereology
doi: 10.25005/2074-0581-2023-25-4-541-552
CURRENT VIEWS ON THE PATHOGENESIS AND EARLY DIAGNOSIS OF ACTINIC KERATOSIS
1Fergana Medical Institute of Public Health, Fergana, Republic of Uzbekistan
2Tashkent State Dental Institute, Tashkent, Republic of Uzbekistan
3Dermatology and Venereology Dispensary № 9, St. Petersburg, Russian Federation
Methods: The article provides an overview of the epidemiology and pathogenesis of actinic keratosis (AK) and its clinical differentiation from cutaneous squamous cell carcinoma (SCC). The authors present varying perspectives on the prognosis of the disease's development and its pathogenetic link to SCC, highlighting the significance of early diagnosis of the malignant transformation. Researchers suggest several markers, such as p16, p53, and p63, to identify the malignant transition in its early stages. The authors support their hypothesis by offering that mutations in genes that express these proteins directly impact the progression of the disease. Another group of authors, recognizing the significant role of inflammation in the pathogenesis of AK, suggest determining the level of various cytokines, emphasizing the essential role of UV radiation in triggering the entire pathogenetic cascade of AK development. Meanwhile, most authors acknowledge that various proteins act as early immunohistochemical (IHC) markers of an unfavorable disease prognosis. They describe the pathogenetic mechanisms of the effect of markers such as p16, p53, p63, and Bcl-2. Research is underway to identify new markers, such as claudin and T-cadherin. In August 2023, a search was conducted on the PubMed Clinical Queries database using keywords such as "actinic keratosis", "pathogenesis of actinic keratosis", and "progression of actinic keratosis to squamous cell carcinoma" to look for early markers of malignancy. The search strategy included clinical trials, observational studies, case reports, and literature reviews published in the last decade. However, sources without peer review, such as educational and methodological guidelines, recommendations, and conference proceedings, were excluded. The information obtained through this search was used to compile this article, and promising directions for the search for early malignancy markers were identified.
Keywords: Actinic keratosis, pathogenesis, clinical forms, early diagnostic markers, progression, squamous cell carcinoma, precancerous skin diseases.
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Authors' information:
Sydikov Akmal Abdikakharovich,
Doctor of Medical Sciences, Full Professor, Rector of Fergana Medical Institute of Public Health
ORCID ID: 0000-0002-0909-7588
SPIN: 3812-8400
Author ID: 799109
E-mail: medik85@bk.ru
Pyagay Grigoriy Borisovich,
Candidate of Medical Sciences, Associate Professor of the Department of Dermato-oncopathology, Tashkent State Dental Institute
ORCID ID: 0000-0002-6456-6594
SPIN: 29417297
Author ID: 1106302
E-mail: gregbae@mail.ru
Pyagay Olga Grigorievna,
Dermatovenereologist, St. Petersburg Dermatology and Venereology Dispensary № 9
ORCID ID: 0000-0002-6379-5563
SPIN: 8357-9048
Author ID: 1206814
E-mail: olga.pyagay@gmail.com
Information about support in the form of grants, equipment, medications
The authors did not receive financial support from manufacturers of medicines and medical equipment
Conflicts of interest: No conflict
Address for correspondence:
Pyagay Grigoriy Borisovich
Candidate of Medical Sciences, Associate Professor of the Department of Dermato-oncopathology, Tashkent State Dental Institute
100213, Republic of Uzbekistan, Tashkent, Makhtumkuli str., 103
Tel.: +998 (901) 755133
E-mail: gregbae@mail.ru
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