Literature Reviews

doi: 10.25005/2074-0581-2020-22-2-286-295
ACTUAL PROBLEMS OF VARICOCELE IN ADOLESCENTS

K.P. Artykov1,2, D. Khuseynzoda1,2, M. A. Yuldoshov3, I.N. Khvan1

1Department of Surgical Diseases № 2, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan
2Republican Scientific Center for Cardiovascular Surgery, Dushanbe, Republic of Tajikistan
3Department of Surgery, Tajik National University, Dushanbe, Republic of Tajikistan

In recent years, cases of detection of varicocele in adolescent age have increased and the using methods of treatment for this population remain controversial. The literature analysis revealed a variety of approaches to the therapy of the pathology: there are supporters of both surgical treatment and conservative therapy and dynamic surveillance. It is known that about 20-40% of adolescents with varicocele are potentially infertile, and they need early surgery for indications such as testicle hypotrophy, pathospermia. However, the existing methods of treatment of varicocele are accompanied by the recurrence, with hydrocele development, and progressive testicle injuries. Furthermore, the results of applicable methods of treatment are limited, characterized by low evidence, lack of randomized controlled researches.

Keywords: Varicocele, spermatic cord, fertility, adolescents, treatment.

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References
  1. Damsgaard J, Joensen UN, Carlsen E, Erenpreiss J, Blomberg Jensen M, Matulevicius V, et al. Varicocele is associated with impaired semen quality and reproductive hormone levels: a study of 7035 healthy young men from six European countries. Eur Urol. 2016;70(6):1019-29. Available from: https:// doi.org/10.1016/j.eururo.2016.06.044
  2. Çayan S, Bozlu M, Akbay E. Update on the novel management and future paternity situation in adolescents with varicocele. Turk J Urol. 2017;43(3):241- 6. Available from: https://doi.org/10.5152/tud.2017.01033
  3. Bae K, Shin HS, Jung HJ, Kang SH, Jin BS, Park JS. Adolescent varicocele: are somatometric parameters a cause? Korean J Urol. 2014;55(8):533-5. Available from: https://doi.org/10.4111/kju.2014.55.8.533
  4. Alsaikhan B, Alrabeeah K, Delouya G, Zini A. Epidemiology of varicocele. Asian J Androl. 2016;18(2):179-81. Available from: https://doi.org/10.4103/1008- 682X.172640
  5. Sorokin I, Welliver C, Elebyjian L, Feustel PJ, McCullough A. Interinstitutional variability in testicular volumes and varicocele presence by ultrasound: surprising discrepancies and implications for clinical decision making. Urology. 2015;85(5):1079-84. Available from: https://doi.org/10.1016/j.urology.2015.02.018
  6. Silay MS, Hoen L, Quadackaers J, Undre S, Bogaert G, Dogan HS, et al. Treatment of varicocele in children and adolescents: a systematic review and meta-analysis from the European Association of Urology/European Society for Paediatric Urology Guidelines Panel. Eur Urol. 2019;75(3):448-61. Available from: https://doi.org/10.1016/j.eururo.2018.09.042
  7. Practice Committee of the American Society for Reproductive Medicine; Society for Male Reproduction and Urology. Report on varicocele and infertility: a committee opinion. Fertil Steril. 2014;102(6):1556-60. Available from: https://doi.org/10.1016/j.fertnstert.2014.10.007
  8. Locke JA, Noparast M, Afshar K. Treatment of varicocele in children and adolescents: a systematic review and meta-analysis of randomized controlled trials. J Pediatr Urol. 2017;13(5):437-45. Available from: https://doi. org/10.1016/j.jpurol.2017.07.008
  9. Bogaert GA. Adolescent varicocele: limited indications for treatment during puberty and adolescence. Transl Androl Urol. 2014;3(4):398-401. Available from: https://doi.org/10.3978/j.issn.2223-4683.2014.12.10
  10. Bryniarski P, Kaletka Z, Huk J, Fryczkowski M, Prokopowicz G, Zyczkowski M, et al. Testicular volume and fertility potential in men operated due to varicocele and testicular hypotrophy in adolescence. Cent European J Urol. 2013;66(1):56-9. Available from: https://doi.org/10.5173/ceju.2013.01. art18
  11. Khasnavis S, Kogan BA. Natural history of testicular size in boys with varicoceles. J Pediatr Urol. 2015;11(3):148.e1-5. Available from: https://doi. org/10.1016/j.jpurol.2015.02.014
  12. Chiba K, Fujisawa M. Clinical outcomes of varicocele repair in infertile men: a review. World J Mens Health. 2016;34(2):101-9. Available from: https://doi. org/10.5534/wjmh.2016.34.2.101
  13. Marmar JL. The evolution and refinements of varicocele surgery. Asian J Androl. 2016;18(2):171-8. Available from: https://doi.org/10.4103/1008- 682X.170866
  14. Komarova SYu, Tsap NA. Puti snizheniya riska reproduktivnykh poter’ u detey s varikotsele [Ways to reduce the risk of reproductive health in children with varicocele]. Meditsinskaya nauka i obrazovanie Urala. 2017;18(1):98-101.
  15. Berdnikov MA, Antipov NV. Varikotsele: sovremennaya problema [Varicocele: the modern problem]. Zhurnal fundamental’noy meditsiny i biologii. 2016;3:42-50.
  16. Bogaert G, Orye C, De Win G. Pubertal screening and treatment for varicocele do not improve chance of paternity as adult. J Urol. 2013;189(6):2298-303. Available from: https://doi.org/10.1016/j.juro.2012.12.030
  17. Kolon TF. Evaluation and management of the adolescent varicocele. J Urol. 2015;194(5):1194-201. Available from: https://doi.org/10.1016/j. juro.2015.06.079
  18. Evdokimov VV, Zakharikov SV, Kastrikin YuV. Varikotsele u detey i podrostkov [The varicocele in children and adolescents]. Lechenie i profilaktika. 2017;1:53-6.
  19. Zampieri N, Bosaro L, Costantini C, Zaffagnini S, Zampieri G. Relationship between testicular sperm extraction and varicocelectomy in patients with varicocele and nonobstructive azoospermia. Urology. 2013;82(1):74-7. Available from: https://doi.org/10.1016/j.urology.2013.03.037
  20. Esteves SC, Miyaoka R, Roque M, Agarwal A. Outcome of varicocele repair in men with nonobstructive azoospermia: systematic review and meta-analysis. Asian J Androl. 2016;18(2):246-53. Available from: https://doi. org/10.4103/1008-682X.169562
  21. Chu DI, Zderic SA, Shukla AR, Srinivasan AK, Tasian GE, Weiss DA, et al. The natural history of semen parameters in untreated asymptomatic adolescent varicocele patients: A retrospective cohort study. J Pediatr Urol. 2017;13(1):77. e1-77.e5. Available from: https://doi.org/10.1016/j.jpurol.2016.09.008
  22. Osipov IB, Lebedev DA, Komissarov MI. Testikulopatiya u podrostkov s varicotsele [Testiculopathy in adolescent with varicocele]. Pediatr. 2016; 7(2):214.
  23. Poon SA, Gjertson CK, Mercado MA, Raimondi PM, Kozakowski KA, Glassberg KI. Testicular asymmetry and adolescent varicoceles managed expectantly. J Urol. 2010;183(2):731-4. Available from: https://doi.org/10.1016/j. juro.2009.10.028
  24. Gurevich AI, Menovshikova LB, Petrukhina YuV, Severgina ES, Derunova TI, Kovarskiy SL, i dr. Varikocele u detey. Vsegda li nuzhno operirovat’? [Varicocele in children. Is it always necessary to operate?]. Reproduktivnoe zdorov’e detey i podrostkov. 2016;2:66.
  25. Lorenc T, Krupniewski L, Palczewski P, Gołębiowski M. The value of ultrasonography in the diagnosis of varicocele. J Ultrason. 2016;16(67):359-70. Available from: https://doi.org/10.15557/JoU.2016.0036
  26. Rehman KU, Zaneb H, Qureshi AB, Numan A, Yousaf MS, Rabbani I, et al. Pattern of varicocele vein blood gases in patients undergoing microsurgical varicocelectomy. BMC Urol. 2018;18(1):104. Available from: https://doi. org/10.1186/s12894-018-0411-y
  27. Brannigan RE. Introduction: Varicoceles: a contemporary perspective. Fertil Steril. 2017;108(3):361-3. Available from: https://doi.org/10.1016/j.fertnstert.2017.07.1161
  28. Goulis DCh, Mintziori G, Koliakos N, Hatzichristou D, Papadimas I, Hatzimouratidis K, et al. Inhibin B and anti-Müllerian hormone in spermatic vein of subfertile men with varicocele. Reprod Sci. 2011;18(6):551-5. Available from: https://doi.org/10.1177/1933719110393024
  29. Apolikhin OI, Efremov EA, Shekhovtsov SYu, Kastrikin YuV. Sravnitel’nyy analiz metodov khirurgicheskogo lecheniya varicotsele [Comparative analysis of methods of surgical treatment of varicocele]. Kreativnaya khirurgiya i onkologiya. 2017;7(4):21-26. Available from: https://doi. org/10.24060/2076-3093-2017-7-4-21-26
  30. Fine RG, Gitlin J, Reda EF, Palmer LS. Barriers to use of semen analysis in the adolescent with a varicocele: Survey of patient, parental, and practitioner attitudes. J Pediatr Urol. 2016;12(1):41.e1-6. Available from: https://doi. org/10.1016/j.jpurol.2015.06.015
  31. Babaei Jandaghi A, Moradi H, Hamidi Madani A, Nasseh H, Keshavarz Zirak A, Pourghorban R. Real-time scrotal ultrasound of patients with varicoceles: correlation with impaired semen analysis. Eur Radiol. 2014; 4(9):2245-51. Available from: https://doi.org/10.1007/s00330-014-3218-6
  32. Semiz I, Tokgöz O, Tokgoz H, Voyvoda N, Serifoglu I, Erdem Z. The investigation of correlation between semen analysis parameters and intraparenchymal testicular spectral Doppler indices in patients with clinical varicocele. Ultrasound Q. 2014;30(1):33-40. Available from: https://doi.org/10.1097/ RUQ.0000000000000055
  33. Jedrzejewski G, Osemlak P, Wieczorek AP, Nachulewicz P. Testicular sonographic color Doppler dynamic tissue perfusion measurements in adolescents with varicocele. Urol Int. 2019;103(1):55-61. Available from: https:// doi.org/10.1159/000500027
  34. Mahdavi A, Heidari R, Khezri M, Shiravi A, Pirjani R, Saheb Kashaf R. Can ultrasound findings be a good predictor of sperm parameters in patients with varicocele? A cross-sectional study. Nephrourol Mon. 2016;8(5):e37103.
  35. Cimador M, Castagnetti M, Gattuccio I, Pensabene M, Sergio M, De Grazia E. The hemodynamic approach to evaluating adolescent varicocele. Nat Rev Urol. 2012;9(5):247-57. Available from: https://doi.org/10.1038/nrurol.2012.41
  36. Lee TH, Jung JH, Hong YK. Diagnosis and management of pediatric and adolescent varicocele: a survey of pediatric urologists in Korea. Chonnam Med J. 2016;52(3):207-11. Available from: https://doi.org/10.4068/ cmj.2016.52.3.207
  37. Kogan MI, Afoko A, Tampuori D, Asanti-Asamani A, Pipchenko OI. Varikotsele: protivorechiya problemy [Varicocele: contradictions of the problem]. Urologiya. 2009;6:67-72.
  38. Van Batavia JP, Badalato G, Fast A, Glassberg KI. Adolescent varicocele – is the 20/38 harbinger a durable predictor of testicular asymmetry? J Urol. 2013;189(5):1897-901. Available from: https://doi.org/10.1016/j. juro.2012.11.011
  39. Van Batavia JP, Fast AM, Nees SN, Mercado MA, Gaselberti A, Glassberg KI. Incidence, significance and natural history of persistent retrograde venous flow after varicocelectomy in children and adolescents: correlation with catch-up growth. J Urol. 2013;190(2):689-95. Available from: https://doi. org/10.1016/j.juro.2013.02.3195
  40. Lee YJ, Cho SY, Paick JS, Kim SW. Usefulness of 2010 World Health Organization reference values for determining indications for varicocelectomy. Urology. 2015;85(4):831-5. Available from: https://doi.org/10.1016/j.urology.2015.01.012
  41. Pastuszak AW, Kumar V, Shah A, Roth DR. Diagnostic and management approaches to pediatric and adolescent varicocele: a survey of pediatric urologists. Urology. 2014;84(2):450-5. Available from: https://doi.org/10.1016/j. urology.2014.04.022
  42. Van Batavia JP, Woldu SL, Raimondi PM, Spencer BA, Insel BJ, Poon SA, Glassberg KI. Adolescent varicocele: influence of Tanner stage at presentation on the presence, development, worsening and/or improvement of testicular hypotrophy without surgical intervention. J Urol. 2010;184(4 Suppl):1727-32. Available from: https://doi.org/10.1016/j.juro.2010.05.053
  43. Çayan S, Şahin S, Akbay E. Paternity rates and time to conception in adolescents with varicocele undergoing microsurgical varicocele repair vs observation only: a single institution experience with 408 patients. J Urol. 2017;198(1):195-201. Available from: https://doi.org/10.1016/j. juro.2017.01.066
  44. Coutinho K, McLeod D, Stensland K, Stock JA. Variations in the management of asymptomatic adolescent grade 2 or 3 left varicoceles: a survey of practitioners. J Pediatr Urol. 2014;10(3):430-4. Available from: https://doi. org/10.1016/j.jpurol.2013.11.001
  45. Elzanaty S. Varicocele repair in non-obstructive azoospermic men: diagnostic value of testicular biopsy – a meta-analysis. Scand J Urol. 2014;48(6):494-8. Available from: https://doi.org/10.3109/21681805.2014.932839
  46. Waalkes R, Manea IF, Nijman JM. Varicocele in adolescents: a review and guideline for the daily practice. Arch Esp Urol. 2012;65(10):859-71.
  47. Dohle GR, Diemer T, Kopa Z, Krausz C, Giwercman A, Jungwirth A; European Association of Urology Working Group on Male Infertility. European Association of Urology guidelines on vasectomy. Eur Urol. 2012;61(1):159-63. Available from: https://doi.org/10.1016/j.eururo.2011.10.001
  48. Johnson D, Sandlow J. Treatment of varicoceles: techniques and outcomes. Fertil Steril. 2017;108(3):378-84. Available from: https://doi.org/10.1016/j. fertnstert.2017.07.020
  49. Christman MS, Zderic SA, Canning DA, Kolon TF. Active surveillance of the adolescent with varicocele: predicting semen outcomes from ultrasound. J Urol. 2014;191(5):1401-6. Available from: https://doi.org/10.1016/j. juro.2013.11.020
  50. Lurvey R, Durbin-Johnson B, Kurzrock EA. Adolescent varicocele: A large multicenter analysis of complications and recurrence in academic programs. J Pediatr Urol. 2015;11(4):186.e1-6. Available from: https://doi.org/10.1016/j. jpurol.2015.05.003
  51. Jacobson DL, Johnson EK. Varicoceles in the pediatric and adolescent population: threat to future fertility? Fertil Steril. 2017;108(3):370-7. Available from: https://doi.org/10.1016/j.fertnstert.2017.07.014
  52. Shiraishi K, Oka S, Matsuyama H. Surgical comparison of subinguinal and high inguinal microsurgical varicocelectomy for adolescent varicocele. Int J Urol. 2016;23(4):338-42. Available from: https://doi.org/10.1111/iju.13050
  53. Halpern J, Mittal S, Pereira K, Bhatia S, Ramasamy R. Percutaneous embolization of varicocele: technique, indications, relative contraindications, and complications. Asian J Androl. 2016;18(2):234-8. Available from: https://doi. org/10.4103/1008-682X.169985
  54. Artykov KP, Kurbanov UA, Davlyatov AA, Baratov AK. Formirovanie testikulo-iliakalnykh venoznykh anastomozov pri lechenii varikotsele [Formation of testicular-iliac venous anastomoses in the treatment of varicocele]. Angiologiya i sosudistaya khirurgiya. 2002;4:57-61.
  55. Ishonakov KhS, Kadyrov ZA, Kodiri TR, Saydulloev L. Epidemiologi-cheskie aspekty dvustoronnego varikotsele [Epidemiological aspects of bilateral varicocele]. Zdravookhranenie Tadzhikistana. 2009;4:36-9.
  56. Kadyrov ZA, Ishonakov KhS, Togoev AM, Smolyakov VA. Laparoskopicheskoe i mikrokhirurgicheskoe ligirovanie vnutrennikh semennykh ven pri dvustoronnem varikotsele [Laporascopic and microsurgical ligation of the internal seminal veins in bilateral varicocele]. Zdravookhranenie Tadzhikistana. 2010;1:38-42.
  57. Artykov KP, Malikov MKh, Khuseynzoda D, Khomidov FM, Abdullaev ZR. Rezul’taty razlichnykh khirurgicheskikh metodov lecheniya varikotsele [The results of the various surgical methods of treatment of varicocele]. Vestnik Akademii meditsinskikh nauk Tadzhikistana. 2018;8(4):408-12.
  58. Tsukanov AYu, Semikina SP, Mustafaev RF. Varikotsele kak proyavlenie sindroma displazii soedinitel’noy tkani [Varicocele as a manifestation of connective tissue dysplasia]. Urologicheskie vedomosti. 2019;9(2):11-6. Available from: https://doi.org/10.17816/uroved9211-16
  59. Krupin VN, Uezdnyy MN, Petrova PI. Vliyanie operativnogo lecheniya varikotsele na razvitie arterial’noy gipertenzii [Influence of operative treatment of variсocele on the development of arterial hypertension]. Urologicheskie vedomosti. 2019;9(4):25-30. Available from: https://doi.org/10.17816/ uroved9425-30
  60. Krupin VN, Uezdnyy MN, Zubova SYu, Petrova PI. Sostoyanie krovotoka v levoy pochechnoy vene pri operativnom lechenii varikotsele [Blood flow condition in the left renal vein in operative treatment of patients with varicocele]. Urologicheskie vedomosti. 2020;10(1):33-8. Available from: https:// doi.org/10.17816/uroved10133-38
  61. Malekzadeh S, Fraga-Silva RA, Morère PH, Sorega A, Produit S, Stergiopulos N, et al. Varicocele percutaneous embolization outcomes in a pediatric group: 7-year retrospective study. Int Urol Nephrol. 2016;48(9):1395-9. Available from: https://doi.org/10.1007/s11255-016-1340-x
  62. Harel M, Herbst KW, Nelson E. Practice patterns in the surgical approach for adolescent varicocelectomy. Springerplus. 2015;4:772. Available from: https://doi.org/10.1186/s40064-015-1573-7
  63. Keene DJB, Cervellione RM. Antegrade sclerotherapy in adolescent varicocele patients. J Pediatr Urol. 2017;13(3):305.e1-305.e6. Available from: https://doi.org/10.1016/j.jpurol.2016.12.018
  64. Zampieri N, Chironi C, Sulpasso M. Treatment of varicocele with transfemoral retrograde sclero-embolization in pediatric patients under local anesthesia. Minerva Pediatr. 2015;67(3):227-9.
  65. Hawkins CM, Racadio JM, McKinney DN, Racadio JM, Vu DN. Varicocele retrograde embolization with boiling contrast medium and gelatin sponges in adolescent subjects: a clinically effective therapeutic alternative. J Vasc Interv Radiol. 2012;23(2):206-10. Available from: https://doi.org/10.1016/j. jvir.2011.10.021
  66. Wang F, Chen Y, Zhao J, Zhong H, Li Y, Shi Z. Subcutaneous endoscopically assisted ligation of spermatic vessels (SEAL-SV) using an epidural-&-spinal needle: a novel technique to repair adolescent varicocele. Pediatr Surg Int. 2017;33(8):917-9. Available from: https://doi.org/10.1007/s00383-017- 4117-0

Authors' information:


Аrtykov Karimdzhon Pulatovich
Doctor of Medical Sciences, Full Professor, Professor of the Department of Surgical Diseases № 2, Avicenna Tajik State Medical University; Leading Specialist in the Training of Scientific Personnel, Republican Scientific Center for Cardiovascular Surgery
Scopus ID: 6506551678
ORCID ID: 0000-0002-6346-0851
SPIN: 2480-6526
Author ID: 909829
E-mail: artikov53@mail.ru

Khuseynzoda Dzhamshed
Applicant, Republican Scientific Center for Cardiovascular Surgery; Senior Laboratory Assistant, Department of Surgical Diseases № 2, Avicenna Tajik State Medical University
ORCID ID: 0000-0003-0537-4426
SPIN: 1738-7633
Author ID: 1066802
E-mail: dkhuseynzoda@bk.ru

Yuldoshov Murodali Arabovich
Candidate of Medical Sciences, Assistant of the Department of Surgery, Tajik National University
ORCID ID: 0000-0003-1208-9519
SPIN: 1049-0339
Author ID: 1066751
E-mail: dr.murodali@gmail.com

Khvan Igor Nikolaevich
Candidate of Medical Sciences, Associate Professor of the Department of Surgical Diseases № 2, Avicenna Tajik State Medical University
Researcher ID: AAJ-7209-2020
ORCID ID: 0000-0002-8108-4087
SPIN: 1342-3314
Author ID: 466108
E-mail: igor_khvan@bk.ru

Information about support in the form of grants, equipment, medications

The work was carried our according to the plan of scientific research works of Avicenna Tajik State Medical University (state registration number – 0116TJ00602). The authors did not receive financial support from manufacturers of medicines and medical equipment

Conflicts of interest: No conflict

Address for correspondence:


Аrtykov Karimdzhon Pulatovich
Doctor of Medical Sciences, Full Professor, Professor of the Department of Surgical Diseases № 2, Avicenna Tajik State Medical University; Leading Specialist in the Training of Scientific Personnel, Republican Scientific Center for Cardiovascular Surgery

734003, Republic of Tajikistan, Dushanbe, Rudaki Ave., 139

Tel.: +992 (919) 401616

E-mail: artikov53@mail.ru