Literature Reviews

doi: 10.25005/2074-0581-2018-20-2-3-190-196
EPIDEMIOLOGY, RISK FACTORS AND DIAGNOSIS OF CHRONIC RENAL FAILURE

M.K. Gulov1, Kh.K. Rafiev2, S.M. Abdulloev2

1Department of General Surgery № 1, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan
2Department of Epidemiology, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan

Objective: Analysis of the literature shows that the number of patients with chronic renal failure (CRF) increases every year. To date known more than twenty renal diseases, the end of clinical manifestation of which is CRF. Studies of recent years show that in CRF genesis and progression leading role plays arterial hypertension, smoking, age, male sex, dyslipidemia, diabetes mellitus, some autoimmune diseases, metabolic disorders of calcium and phosphorus, the use of nephrotoxic drugs, the effects of psycho-emotional and oxidative stress, malfunction of the renin-angiotensin-aldosterone system, etc. At the present stage, for diagnosis of violations of the glomerular filtration rate, ordered ten, most important of them - Cystatin C method. Another non-invasive method is doppler ultrasound. In spite of this, the issues of early diagnosis of chronic kidney disease remain to the end not studied and not solved, which requires the development of new working algorithms.

Keywords: Chronic renal failure, epidemiology, glomerular filtration rate, cystatin C, outcomes.

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Authors informations:

Gulov Mahmadshoh Kurbonalievich, Doctor of Medical Sciences, Full Professor, Professor of the Department of General Surgery № 1, Avicenna TSMU

Rafiev Khamdam Kutfiddinovich, Doctor of Medical Sciences, Full Professor, Professor of the Department of Epidemiology, Avicenna TSMU

Abdulloev Saidkhodzha Murtazoevich, Competitor of the Department of Epidemiology, Avicenna TSMU

Address for correspondence:

Abdulloev Saidkhodzha Murtazoevich

Competitor of the Department of Epidemiology, Avicenna TSMU

734003, Republic of Tajikistan, Dushanbe, Rudaki Ave., 139

Tel.: (+992) 44 6003673

E-mail: saidxoja@gmail.com