Oncology

doi: 10.25005/2074-0581-2017-19-4-487-491
INDICATORS OF ANTICOAGULATIVE ACTIVITY OF VASCULAR WALL DEPENDING ON STAGE OF BREAST CANCER

I.L. Ivanenko1, S.I. Veretennikov2, V.V. Nikitina1, V.V. Blinova3, E.A. Rogozhnikova2, S.S. Veretennikov2

1Department of Clinical Laboratory Diagnostics, Saratov State Medical University named after V.I. Razumovsky, Saratov, Russia
2Department of Operative Surgery and Topographic Anatomy, Saratov State Medical University named after V.I. Razumovsky, Saratov, Russia
3Department of Therapy, Gastroenterology and Pulmonology, Saratov State Medical University named after V.I. Razumovsky, Saratov, Russia

Objective: Detection the intensity of changes in the anticoagulant activity of the vascular wall, depending on the stage of breast cancer.

Methods: Study of the hemostasis system carried out in 84 women who had medical treatment in the Oncology Department of the Road Clinical Hospital with a diagnosis of breast cancer and received chemotherapy, radiation therapy and surgical treatment in various combinations. The comparison group consisted of 35 women without oncological pathology of the same age.

Results: According to the results of the cuff test, the most pronounced inhibition of the ability of the endothelium to produce activators of fibrinolysis, anticoagulants and antiplatelet agents before and after the operation revealed in patients with stage II and III of the tumour process.

Conclusions: The revealed changes in the anticoagulant activity of the vascular wall indicate an increased risk of thrombogenic complications after surgical intervention in patients with stage II and III breast cancer.

Keywords: Hemostasis system, breast cancer, stage of the disease.

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Authors informations:

Ivanenko Irina Lvovna, Candidate of Medical Sciences, Associate Professor of the Department of Clinical Laboratory Diagnostics, Saratov State Medical University named after V.I Razumovsky

Veretennikov Sergey Ivanovich, Candidate of Medical Sciences, Senior Lecturer, Department of Operative Surgery and Topographic Anatomy, Saratov State Medical University named after V.I Razumovsky

Nikitina Victoria Viktorovna, Candidate of Medical Sciences, Associate Professor of the Department of Clinical Laboratory Diagnosis, Saratov State Medical University named after V.I Razumovsky

Blinova Viktoria Viktorovna, Candidate of Medical Sciences, Assistant of the Department of Therapy, Gastroenterology and Pulmonology, Saratov State Medical University named after V.I Razumovsky

Rogozhnikova Elena Aleksandrovna, Candidate of Medical Sciences, Assistant of the Department of Operative Surgery and Topographic Anatomy, Saratov State Medical University named after V.I Razumovsky

Veretennikov Sergey Sergeevich, Candidate of Medical Sciences, Laboratory Assistant of the Department of Operative Surgery and Topographic Anatomy, Saratov State Medical University named after V.I Razumovsky

Address for correspondence:

Ivanenko Irina Lvovna

Candidate of Medical Sciences, Associate Professor of the Department of Clinical Laboratory Diagnostics, Saratov State Medical University named after V.I Razumovsky

401076, Russian Federation, Saratov, str. Chernyshevsky, Building 20, Apt. 39

Tel.: (+7) 960 3530807

E-mail: eginda@rambler.ru

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