Pediatrics

doi: https://dx.doi.org/10.25005/2074-0581-2017-19-1-73-77
ANTIOXIDANT DEFENSE AND PECULIARITIES OF LIPID PEROXIDATION IN CHILDREN WITH BRONCHIAL ASTHMA

K.I. Ismoilov, А.M. Saburova, M.M. Sharipova

Department of pediatric Diseases № 2, avicenna Tajik state medical university, Dushanbe, Tajikistan
Department of biochemistry, avicenna Tajik state medical university, Dushanbe, Tajikistan

Objective: To research peculiarities of the lipid peroxidation and antioxidant system in children with bronchial asthma.

Methods: It has taken the results of the research in 56 children aged from 5 to 14 years, who suffered with bronchial asthma (BA). Along with the general clinical examination, spirometry were used to identify respiratory function, and malondialdehyde (MDA) and superoxide dismutase contents in blood serum were analyzed.

Results: Spirometry in all BA patients from attack of disease up to attack-free interval showed increasing of forced expiratory volume in 1 second (from 61.5±3.70% to 84.3±5.33%) and maximum voluntary ventilation (from 59.1±4.21% to 81.7±6.31%), and decreasing of residual volume (from 117.4±6.01% to 93.1±5.25%) . Biochemical studies revealed increase in the content of MDA (3.2±0.04), reduced activity of superoxide dismutase (10.7±0.2) and reduced content of ascorbic acid (57.6±0.28) in blood serum in children with BA.

Conclusions: At the time of attacks in children lipid peroxidation processes are intensified and followed by increasing development of lipid peroxidation products (MDA), depletion of antioxidant system in blood serum, lower activity of superoxide dismutase, and increased sialic acid, which facilitates development of immune-inflammatory process in the bronchopulmonary system. Administration of Mexidol in children with BA led to earlier elimination of the key clinical and paraclinical implications such as: elimination of asthma attacks, disappearance of pulmonary rale, improved respiratory function parameters, and indicators of lipid peroxidation and antioxidant system in the blood serum.

Keywords: Bronchial asthma, children, lipid peroxidation, antioxidants.

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References
  1. Baranov AA, Namazova-Baranova LS, Haitov RM, Ilina NI, Kurbachova OM, Novik GA, i dr. Federal’nye klinicheskie rekomendatsii po okazaniyu meditsinskoy pomoshchi detyam s bronkhial’noy astmoy [Federal clinical guidelines for the provision of medical care for children with bronchial asthma]. Moscow, RF; 2016. 33 p.
  2. Natsional’naya programma “Bronchial’naya astma u detey. Strategiya lecheniya i profilaktika” [The national program «Bronchial asthma in children. The strategy of treatment and prevention”]. 4-e izd., pererab. i dop. Moscow, RF: Original-maket; 2012. 184 p.
  3. Burkhart PV. Children’s self-reports of characteristics of their asthma episodes: The Journal of Asthma. 2003;40:909-16. Cochrane Database of Systematic Reviews 2003, Issue 8. Art. No.: CN-00496647.
  4. Phaniendra A. Free radicals: properties, sources, targets, and their implication in various diseases. Indian J Clin Biochem. 2015;30(1):11-26.
  5. Nadeem A. Airway and systemic oxidant-antioxidant dysregulation in asthma: a possible scenario of oxidants spill over from lung into blood. Pulm Pharmacol Ther. 2014;29(1):31-40.
  6. Artykova TK, Ismailov KI. Perekisnoe okislenie lipidov i antioksidantnaya zashchita organizma u detey s vegeto-sosudistoy distoniey [Peroxide oxidation of lipids and antioxidant defense of the organism in children with vegetative-vascular dystonia]. Avicenna Bulletin (Vestnik Avitsenny). 2015;3:117-20.
  7. Balabolkin II. Bronkhial’naya astma u detey [Bronchial asthma in children]. Moscow, RF: MIA; 2015. 141 p.
  8. Al-Harbi NO. Oxidative airway inflammation leads no systemic and vascular oxidative stress in a murine model of allergic asthma. Int Immunofarmacol. 2015; 26(1):237-45.
  9. Nadeem A, Masood A, Siddiqui N. Oxidant-antioxidant imbalance in asthma: scientific evidence, epidemiological data and possible therapeutic options. Ther Adv Respir Dis. 2008;2(4):215-35
  10. Larkin EK. New risk factors for adult-onset incident asthma. A nested casecontrol study of host antioxidant defense. Am J Respir Crit Care Med. 2015;191(1):45-53.
  11. Budnevskiy FV. Vozmozhnosti kontrolya nad bronkhial’noy astmoy: rol’ malykh dykhatel’nykh putey [The possibility of bronchial asthma control: the role of small airways]. Pulmonologiya. 2011;2:101-8.
  12. Kolpakova AF. Vliyanie kombinirovannoy terapii otechestvennymi ingalyatsionnymi protivoastmaticheskimi preperatami na oksidantno-antioksidantnyy status bol’nykh bronkhial’noy astmoy [The effect of combined therapy with domestic inhaled antiasthmatic drugs on the oxidant-antioxidant status of patients with bronchial asthma]. Therapeutic archive. 2007;3:41-4.
  13. Soodaeva SK. Narusheniya okislitel’nogo metabolizma pri zabolevaniyakh respiratornogo trakta i sovremennye podkhody k antioksidantnoy terapii [Disorders of oxidative metabolism in diseases of the respiratory tract and modern approaches to antioxidant therapy]. Atmosfera. Pulmonologiya i allergologiya. 2009;1:34-8.
  14. Balabolkin II. Farmakogeneticheskie markyory еffektivnosti terapii detey s atopicheskoy bronkhial’noy astmoy [Pharmacogenetic markers of the effectiveness of therapy in children with atopic bronchial asthma]. Experimental and Clinical Pharmacology. 2016;11:35-40.
  15. Milan SJ. Vitamin C for asthma and exercise-induced bronchoconstriction. The Journal of Asthma. 2013;10:104-13. Cochrane Database of Systematic Reviews 2003, Issue 8. Art. No.:CN-00496647.
  16. Filatova YuI, Znachenie perekisnogo okisleniya lipidov v mekhanizme khronicheskogo vospalitel’nogo protsessa pri bronkhial’noy astme [The importance of lipid peroxidation in the mechanizms of chronic inflammatory process in bronchial astma]. V kn.: «Meditsina I zdravookhranenie». Kazan, RF: Buk; 2015. p

Authors informations:

Ismoilov Komildjon Isroilovich, Doctor of Medical Sciences, Full Professor, Head of the Department of Pediatric Diseases № 2 at Avicenna Tajik State Medical University

Saburova Anna Mukhamedovna, Doctor of Medical Sciences, Full Professor, Professor of the Department of Biochemistry at Avicenna Tajik State MedicalUniversity

Sharipova Mavluda Mirzomuddinovna, postgraduate student of the Department of Pediatric Diseases № 2 at Avicenna Tajik State Medical University

Address for correspondence:

Ismoilov Komildjon Isroilovich

Doctor of Medical Sciences, Full Professor, Head of the Department of Pediatric Diseases № 2 at Avicenna Tajik State Medical University

734003, Republic of Tajikistan, Dushanbe, Rudaki Avenue 139,

Tel.: (+992) 985 127845

E-mail: IsmoilovK@mail.ru

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